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  • Official Full Name

    apolipoprotein E

  • Overview

    Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition.
  • Synonyms

    Apoe; AI255918; apolipoprotein E; apo-E;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Cattle
  • Dog
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human plasma
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • S.frugiperda
  • Yeast
  • C
  • His
  • Myc
  • DDK
  • Flag
  • His (Fc)
  • Avi
  • His|GST
  • His|Myc
  • His|T7
  • B2M
  • SUMO
  • MYC
  • N/A
  • N
  • Trx
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APOE-1377H Active Recombinant Human APOE Protein, His-tagged E.coli His 19-317 aa
Human APOE-2630H Recombinant Human Apolipoprotein E, E2 Isoforms S.frugiperda N/A
Human APOE-694H Recombinant Human Apolipoprotein E, E4 Isoform E.coli N/A
Human APOE-6865H Recombinant Human APOE protein(Lys19-His317), His&Trx-tagged E.coli N-His&Trx Lys19-His317
Human APOE-257H Recombinant Human APOE protein E.coli N/A 299 amino acids
Human APOE-17H Recombinant Human APOE Protein, His-tagged HEK293 His
Human APOE-695H Recombinant Human Apolipoprotein E, E2 Isoform E.coli N/A
Human APOE-8780HCL Recombinant Human APOE 293 Cell Lysate HEK293 N/A
Human APOE-57H Recombinant Human APOE Protein, His-tagged Human Cell His
Human APOE-2153H Recombinant Human APOE protein, His-tagged HEK293 His Lys 19 - His 317 (R154S,R176C)
Human APOE-364H Recombinant Human APOE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human APOE-1378H Recombinant Human APOE4 Protein, His-tagged E.coli His
Human APOE-364H-B Recombinant Human APOE Protein Pre-coupled Magnetic Beads HEK293
Human APOE-56H Recombinant Human APOE Protein, His-tagged HEK293 His
Human APOE-088H Active Recombinant Human APOE Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human APOE-087H Recombinant Human APOE Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human APOE-0635H Recombinant Human APOE Protein (Lys19-His317), His-tagged E.coli His Lys19-His317
Human APOE-238HFL Active Recombinant Full Length Human APOE Protein, C-Flag-tagged Mammalian cells Flag
Human APOE-17HCy5 Recombinant Human APOE Protein, His-tagged, Cy5 Conjugated HEK293 His
Human APOE-0636H Recombinant Human APOE Protein (Lys19-His317), C-His-tagged Mammalian cells C-His Lys19-His317
Human APOE-0240H Recombinant Human APOE protein, Trx-tagged, Biotinylated E.coli Trx Lys19-His317
Human APOE-17HAF555 Recombinant Human APOE Protein, His-tagged, Alexa 555 Conjugated HEK293 His
Human ApoE-3560H Native Human ApoE Human plasma N/A
Mouse Apoe-25M Recombinant Mouse Apoe protein, His-tagged HEK293 His
Mouse APOE-1792M Recombinant Mouse APOE Protein Mammalian Cell His
Mouse Apoe-687M Recombinant Mouse Apoe protein, His & GST-tagged E.coli His/GST Thr14~Lys167
Mouse Apoe-1128M Recombinant Mouse Apoe protein, His-tagged Yeast His 19-311aa
Mouse Apoe-1129M Recombinant Mouse Aope Protein, His-tagged E.coli His
Mouse Apoe-2199M Recombinant Mouse Apoe protein, His&Myc-tagged Insect Cell His&Myc 19-311aa
Mouse Apoe-4989M Recombinant Mouse Apoe protein, His&Myc-tagged HEK293 His&Myc 19-311aa
Mouse APOE-58M Recombinant Mouse APOE Protein, His-tagged HEK293 His
Mouse APOE-638M Recombinant Mouse APOE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse APOE-638M-B Recombinant Mouse APOE Protein Pre-coupled Magnetic Beads HEK293
Mouse Apoe-5608M Recombinant Mouse Apoe Protein (Glu19-Gln311), C-His tagged Mammalian cells C-His Glu19-Gln311
Mouse Apoe-820M Recombinant Mouse Apoe Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat APOE-726R Recombinant Rat APOE Protein Mammalian Cell His
Rat Apoe-688R Recombinant Rat Apoe protein, His & GST-tagged E.coli His/GST Glu19~Arg168
Rat Apoe-228R Recombinant Rat Apoe Protein, His-tagged E.coli N-His Glu19-Arg168
Rat APOE-382R-B Recombinant Rat APOE Protein Pre-coupled Magnetic Beads HEK293
Rat APOE-382R Recombinant Rat APOE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit APOE-1127R Recombinant Rabbit APOE Protein, His/MYC-tagged E.coli His/Myc
Rabbit APOE-2541R Recombinant Rabbit APOE protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 20-311aa
Rabbit APOE-2542R Recombinant Rabbit APOE protein, His-B2M & Myc-tagged E.coli His-B2M & Myc 20-311aa
Dog APOE-686D Recombinant Dog APOE protein, His & T7-tagged E.coli His/T7 Asp1~Val172 (Accession# P18649)
Dog APOE-6186D Recombinant Dog APOE protein(19-323aa), His&Myc-tagged E.coli N-His&C-Myc 19-323aa
Cattle APOE-226C Recombinant Cattle APOE Protein, His-tagged E.coli N-His Asp19-His316
Pig APOE-227P Recombinant Pig APOE Protein, His-tagged E.coli N-His Cys16-Arg175
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

APOE involved in several pathways and played different roles in them. We selected most pathways APOE participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

APOE has several biochemical functions, for example, antioxidant activity, beta-amyloid binding, cholesterol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOE itself. We selected most functions APOE had, and list some proteins which have the same functions with APOE. You can find most of the proteins on our site.

Function Related Protein
antioxidant activityKDM3B;SEPW1;APOE;TP53INP1;UBIAD1;FAM213AA;PRDX6;APOA4;PRDX5
beta-amyloid bindingBACE1;ACHE;TM2D1;APBB3;APBA3;COL25A1;OLFM1;NGFR;MAPK8IP2
cholesterol transporter activityAPOEB;CETP;ABCA1;ABCA1B;ABCA13;APOA4B.1;APOB;ABCA7;APOEA
identical protein bindingMMP9;S100A4;Serpina1c;CEACAM16;ITGB3;PSME3;MCIN;CCL3;MUL1A
lipid transporter activityVTG1;VTG2;GM2A;APOD;CETP;APOM;APOA4;RFT1;APOBB.1
lipoprotein particle bindingGPIHBP1;MAPT;APOE;CDH13
low-density lipoprotein particle receptor bindingLDLRAP1;CCDC167;HSP90B1;SLC9A3R2;LANCL1;LRPAP1;MMP13;DKK1;APOB
metal chelating activity
phosphatidylcholine-sterol O-acyltransferase activator activityAPOA4B.2;APOA5;APOEB;APOA2;APOA1A;APOC1;APOA1;APOEA;APOA4
protein homodimerization activityLMLN;PLDN;TYMS;PRMT2;NOD1;FBXO4;MYPOP;AMBP;BMP7A
very-low-density lipoprotein particle receptor bindingReln;PCSK9;APOEB;APOEA;APOE;LRPAP1

APOE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOE here. Most of them are supplied by our site. Hope this information will be useful for your research of APOE.

HP; TMCC2; LDLR; p27958-pro_0000037570; ECSIT

Research Area

Related articles

de la Escosura-Muniz, A; Plichta, Z; et al. Alzheimer's disease biomarkers detection in human samples by efficient capturing through porous magnetic microspheres and labelling with electrocatalytic gold nanoparticles. BIOSENSORS & BIOELECTRONICS 67:162-169(2015).
Hu, JH; Touch, P; et al. Reduction of mouse atherosclerosis by urokinase inhibition or with a limited-spectrum matrix metalloproteinase inhibitor. CARDIOVASCULAR RESEARCH 105:372-382(2015).
  • Q&As
  • Reviews

Q&As (18)

Ask a question
Can APOE gene editing or gene therapy be a potential treatment option in the future? 09/02/2021

Gene editing or gene therapy targeting the APOE gene is an area of active research. Many scientific advancements have been made in the field of gene editing, such as CRISPR-Cas9 technology, which allows for precise modifications to genes. However, gene editing and gene therapy approaches for APOE are still in the experimental stage and require further refinement and study before they can become viable treatment options.

Does the APOE protein influence mental health conditions like depression or anxiety? 08/06/2021

While the APOE protein is primarily associated with lipid metabolism and neurodegenerative diseases, emerging evidence suggests it may play a role in mental health. Some studies have found an association between the APOEε4 allele and increased risk of developing late-onset depression or anxiety disorders. However, more research is needed to fully understand the relationship between APOE and mental health conditions.

Can medications or supplements influence the expression or function of the APOE protein? 03/31/2021

Some medications and supplements have been studied for their potential to influence the expression or function of the APOE protein. For example, statins, commonly prescribed for high cholesterol, have shown some effects on APOE expression and metabolism. However, more research is needed to fully understand the impact of medications and supplements on APOE function.

Can genetic testing determine an individual's APOE genotype? 11/17/2020

Yes, genetic testing can determine an individual's APOE genotype. Through a simple blood or saliva sample, the presence of APOE variants (ε2, ε3, ε4) can be detected and analyzed. It is important to note that genetic testing should be done under the supervision of a healthcare professional, as test results need to be interpreted carefully, considering various factors.

Are there any dietary changes that can optimize APOE function? 01/26/2020

Certain dietary changes can help optimize APOE function. Consuming a diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats can support APOE function and overall brain health. Omega-3 fatty acids, found in fatty fish, walnuts, and flaxseeds, have been shown to enhance APOE function and neuroprotective mechanisms.

How does the APOE protein contribute to cardiovascular health? 05/05/2019

The APOE protein helps regulate cholesterol levels by facilitating the transportation of cholesterol and lipids. APOE plays a role in removing excess cholesterol from cells and transporting it back to the liver for metabolism and elimination. This process is important for maintaining cardiovascular health.

Are there any lifestyle factors that can influence the expression or impact of the APOE protein? 04/06/2019

Yes, lifestyle factors can influence the expression and impact of the APOE protein. Regular physical exercise has been shown to increase APOE expression and enhance its function in lipid metabolism and clearance of amyloid-beta. A healthy diet rich in antioxidants, omega-3 fatty acids, and low in saturated fats may also support APOE function and reduce the risk of neurodegenerative diseases.

Does everyone have the same form of the APOE protein? 09/30/2018

No, there are three common forms of the APOE protein known as APOEε2, APOEε3, and APOEε4. Each individual inherits two copies of the APOE gene, resulting in six possible genotypes: APOEε2/ε2, APOEε2/ε3, APOEε2/ε4, APOEε3/ε3, APOEε3/ε4, and APOEε4/ε4.

How does the APOE protein contribute to brain health? 09/21/2018

The APOE protein is crucial for various functions in the brain. It assists in the transport and delivery of lipids required for neuronal growth, maintenance, and repair. It also plays a role in clearing away excess amyloid-beta, a protein associated with the formation of plaques in Alzheimer's disease. APOE isoforms have different abilities to clear amyloid-beta, with APOEε4 being less efficient in clearance, contributing to increased Alzheimer's risk.

What other diseases or conditions are associated with the APOE protein? 06/27/2018

Apart from Alzheimer's disease and cardiovascular health, variations in the APOE protein have also been linked to other conditions. For example, the APOEε4 allele is associated with an increased risk of developing age-related macular degeneration (AMD), a leading cause of vision loss in older adults. Additionally, APOE genotypes have been implicated in cognitive decline, stroke risk, and traumatic brain injury outcomes.

Are there any ongoing clinical trials targeting the APOE protein? 03/17/2018

There are ongoing clinical trials exploring potential interventions targeting the APOE protein. These trials focus on developing drugs or therapies that can modify APOE function, enhance lipid metabolism, reduce amyloid-beta buildup, and improve brain health in conditions such as Alzheimer's disease and other neurodegenerative disorders.

Can lifestyle factors influence the impact of the APOE protein on health? 01/01/2018

Yes, lifestyle factors such as diet, exercise, and maintaining a healthy weight can modulate the impact of the APOE protein on health. A healthy lifestyle, including a balanced diet and regular physical activity, may help mitigate the risk of developing certain diseases associated with APOE genotypes, such as Alzheimer's disease or cardiovascular conditions.

Can the APOE protein impact the response to traumatic brain injury? 08/21/2017

Yes, the APOE genotype can influence the response to traumatic brain injury (TBI). Studies have shown that individuals carrying the APOEε4 allele may be at an increased risk of poorer outcomes after experiencing a TBI. APOE genotype can influence the severity and recovery process, providing insights into personalized approaches for TBI management and rehabilitation.

Can the APOE protein be therapeutic target in cardiovascular diseases? 05/02/2017

The APOE protein has been a target of research for potential therapeutic interventions in cardiovascular diseases. Developing drugs or therapies that modulate APOE function, such as promoting cholesterol efflux or reducing inflammation, might have the potential to improve lipid metabolism and reduce the risk of developing cardiovascular diseases. However, further studies are necessary to develop effective treatments.

How is the APOE protein related to Alzheimer's disease? 04/06/2017

Certain variations in the APOE gene, specifically the APOE ε4 allele, have been identified as a major risk factor for developing late-onset Alzheimer's disease. Individuals with one copy of the APOE ε4 allele have an increased risk, while those with two copies have an even higher risk.

Are there any therapies targeting the APOE protein? 03/09/2017

While there are no specific therapies directly targeting the APOE protein, research is ongoing to understand its role better in various diseases. Potential therapeutic approaches focus on modulating lipid metabolism, reducing cholesterol deposition, and developing treatments for Alzheimer's disease that target the impact of APOE ε4 allele.

Can the APOE protein impact response to dietary fats? 04/13/2016

Yes, the APOE genotype can influence an individual's response to dietary fats. Studies suggest that individuals carrying the APOEε4 allele may be more susceptible to adverse effects of high saturated fat intake, such as elevated cholesterol levels and increased cardiovascular risk.

Are there any potential therapeutic interventions targeting the APOE protein in Alzheimer's disease? 04/10/2016

Researchers are actively studying potential therapeutic interventions targeting the APOE protein in Alzheimer's disease. These interventions aim at increasing the clearance of amyloid-beta plaques, reducing brain inflammation, and promoting brain health. However, no specific treatments directly targeting the APOE protein have been approved for clinical use thus far.

Customer Reviews (4)

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    By using APOE protein, I can gain insights into the underlying molecular processes contributing to amyloidosis, which can ultimately aid in the development of novel therapeutic strategies.


      The manufacturer plays a crucial role in supporting my research with their extensive expertise and resources.


        This assurance enables me to confidently utilize the APOE protein in my research, knowing that it will consistently deliver reliable and accurate results.


          the manufacturer facilitates access to the latest scientific advancements and developments related to APOE protein research.

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