IL11
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Official Full Name
interleukin 11
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Overview
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012] -
Synonyms
IL11; interleukin 11; AGIF; IL-11; interleukin-11; oprelvekin; adipogenesis inhibitory factor;
- Recombinant Proteins
- GMP Proteins
- Cell & Tissue Lysates
- Therapeutic Proteins
- Transfected Stable Cell Lines
- Cynomogus
- Cynomolgus
- Cynomolgus monkey
- Human
- Mouse
- Rat
- CHO
- E.coli
- HEK293
- HEK293F
- Human
- Human Cells
- Insect Cell
- Mammalian cells
- Mouse
- P.pastoris
- Sf21 Insect Cell
- Yeast
- Fc
- His
- Avi
- MBP
- Myc
- T7
- N
- PDI
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
IL11 involved in several pathways and played different roles in them. We selected most pathways IL11 participated on our site, such as Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Integrated Pancreatic Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TNFSF4;KITLGA;TGFBR2;IFNA14;AMHR2;BMPR2B;PDGFAA;IFNW1;CCL23 |
| Hematopoietic cell lineage | THPO;CD33;TFRC;CR2;IL5;FLT3LG;ITGA2B;CD24;Flt3l |
| Integrated Pancreatic Cancer Pathway | TFF1;CD82;CST3;JUND;WRN;CASP12;MST1;FKBP3;BRF1 |
| Interleukin-11 Signaling Pathway | IL11;BGLAP |
| Jak-STAT signaling pathway | MPL;CSH1;CCND1;IFNA2;IL10RB;MTOR;IL17D;SOCS9;IL22RA2 |
| Rheumatoid arthritis | IL1A;Il23a; Il12b;Ccl12;TNFRSF11A;HLA-DMA;CCL3L1;CD86;HLA-DRB1;HLA-DRB3 |
IL11 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-11 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL11 itself. We selected most functions IL11 had, and list some proteins which have the same functions with IL11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | MIF;MSTN;CCL20B;ADIPOQ;IFNW1;NDR2;TXLNA;NRG1;IFNA21 |
| growth factor activity | BMP7A;PDGFC;EREG;LFT2;INHBB;INHBE;FGF17;AMBN;AREG |
| interleukin-11 receptor binding | |
| protein binding | AES;PIP5K1A;LSM5;SPRYD7;TIPIN;TIMP3;AIMP1;NPBWR1;ANKRD45 |
IL11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL11 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL11.
MAGEA11; MAGEA11
Gene Family
Research Area
Related articles
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Customer Reviews (3)
Write a reviewPotent in bone regeneration models.
Suitable for cell culture.
High yield in expression.
Q&As (10)
Ask a questionTransgenic mice and knockdown models explore IL11's impact on tissue regeneration.
Site-directed mutagenesis identifies key residues in IL11's interaction with IL11RA.
Chromatin immunoprecipitation and DNA methylation analysis decipher IL11's regulatory mechanisms.
Proteomics identifies IL11-interacting proteins and potential cross-talk partners.
Cell-based and luciferase reporter assays elucidate IL11's JAK-STAT signaling activation.
RNA sequencing uncovers IL11-induced gene expression changes across different cell types.
X-ray crystallography and NMR spectroscopy reveal structural details of the IL11-IL11RA complex.
Confocal and super-resolution microscopy visualize IL11 localization in tissues.
Techniques like surface plasmon resonance measure IL11-IL11RA binding affinity and kinetics.
CRISPR screening unveils genes and pathways influenced by IL11 signaling.
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