IL11

  • Official Full Name

    interleukin 11

  • Background

    The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
  • Synonyms

    IL11; interleukin 11; AGIF; IL-11; interleukin-11; oprelvekin; adipogenesis inhibitory factor;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Transfected Stable Cell Lines
    • Therapeutic Proteins
    • GMP Proteins
    • Species :
    • Cynomogus
    • Cynomolgus
    • Cynomolgus monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • Human
    • Human Cells
    • Insect Cell
    • Mouse
    • P.pastoris
    • Sf21 Insect Cell
    • Yeast
    • Tag :
    • Fc
    • His
    • Myc
    • His(N
    • ter)
    • His|T7
    • Avi
    • MBP
    • Met
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomogus IL11-938C Recombinant Cynomogus IL11 Protein E. coli
    Cynomogus IL11-939C Recombinant Cynomogus IL11 Protein, His-tagged E. coli His
    Cynomolgus IL11-1580C Recombinant Cynomolgus IL11 protein, His-tagged HEK293 His
    Cynomolgus monkey Il11-1374C Recombinant Cynomolgus monkey Il11 protein, MBP&His-Avi-tagged, Biotinylated E.coli MBP&His-Avi
    Human IL11-5249HCL Recombinant Human IL11 293 Cell Lysate HEK293 N/A
    Human IL11-124H Human Interleukin-11 (rDNA derived) Reference standard N/A
    Human IL11-1581H Recombinant Human IL11 protein, Fc-tagged HEK293 Fc
    Human IL11-061H Recombinant Human IL11 Protein E. coli
    Human IL11-551H Recombinant Human Interleukin 11 Human N/A
    Human IL11-325H Active Recombinant Human IL11 Human N/A
    Human IL11-1582H Recombinant Human IL11 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human IL11-29630TH Recombinant Human IL11 E.coli N/A
    Human IL11-218H Recombinant Human Interleukin 11 Sf21 Insect Cell N/A
    Human IL11-P012H Recombinant Human IL11 therapeutic protein E.coli N/A
    Human IL11-464H Recombinant Human IL11, None tagged E.coli Fc
    Human IL11-121HG GMP Recombinant Human IL11 protein HEK293
    Human IL11-19H Recombinant Human Interleukin-11 Yeast N/A
    Human IL11-123H Recombinant Human IL11 protein E.coli N/A
    Human IL11-416H Active Recombinant Human Interleukin-11 Human N/A
    Human IL11-2016H Recombinant Human IL11 Protein, Met-tagged E.coli Met
    Human IL11-4326HG GMP Recombinant Human IL11 protein E.coli N/A
    Human IL11-130H Recombinant Human IL11 Protein E.coli
    Human IL11-842H Recombinant Human IL11 protein, His & T7-tagged E.coli His/T7
    Human IL11-2597H Recombinant Human IL11 protein E.coli N/A
    Human IL11-101HG GMP Recombinant Human IL11 Protein Insect Cell N/A
    Human IL11-151H Recombinant Human IL11 Protein, His-tagged Human Cells His
    Human IL11-503H Recombinant Human IL11 protein, His-tagged HEK293F His
    Human IL11-2289H Recombinant Human IL11 Protein, His-tagged E.coli N-His
    Human IL11-953H Active Recombinant Human IL11 Protein P.pastoris N/A
    Human IL11-137H Recombinant Active Human IL11 Protein, His-tagged(N-ter) E.coli His(N-ter)
    Human IL11-259I Recombinant Human IL11 Protein CHO
    Human IL11-1583H Recombinant Human IL11 protein, His-tagged HEK293 His
    Mouse Il11-1373M Recombinant Mouse Il11 protein, MBP&His-Avi-tagged, Biotinylated E.coli MBP&His-Avi
    Mouse IL11-1579M Recombinant Mouse IL11 protein, Fc-tagged HEK293 Fc
    Mouse Il11-138M Recombinant Active Mouse IL11 Protein, His-tagged(N-ter) E.coli His(N-ter)
    Mouse IL11-131M Recombinant Mouse IL11 Protein E.coli
    Mouse Il11-085M Recombinant Mouse Il11 Protein E.coli
    Mouse Il11-843M Recombinant Mouse Il11 protein, His-tagged E.coli His
    Mouse Il11-039I Recombinant Mouse Il11 Protein (179 aa) E.coli
    Mouse Il11-182I Recombinant Mouse Il11 Protein HEK293
    Mouse Il11-01M Active Recombinant Mouse Il11 Protein, His-Tagged E.coli His
    Mouse Il11-586M Recombinant Mouse interleukin 11 Mouse N/A
    Mouse Il11-161M Recombinant Mouse Il11 protein E.coli N/A
    Mouse Il11-842M Recombinant Mouse Il11 Protein E.coli N/A
    Rat Il11-1375R Recombinant Rat Il11 protein, MBP&His-Avi-tagged, Biotinylated E.coli MBP&His-Avi
    Rat Il11-1659R Recombinant Rat Il11 Protein, His-tagged E.coli N-His
    Rat Il11-4756R Recombinant Rat Il11 protein, His&Myc-tagged E.coli His&Myc
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL11 Related Articles
    • IL11 Related Gene Family
    • IL11 Related Research Area

    IL11 involved in several pathways and played different roles in them. We selected most pathways IL11 participated on our site, such as Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Integrated Pancreatic Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionPLEKHO2;PRLR;TNFSF4;CSF1RA;BMPR1B;XCL2;IFNAR2;NGFRB;IFNGR1
    Hematopoietic cell lineageCD7;Fcer2a;HLA-DRB5;IL4;GM13305;CD19;FCGR1A;CD37;IL5RA
    Integrated Pancreatic Cancer PathwayNOXA1;WRN;IL11;CASP12;FST;RB1CC1;TFF1;FKBP1B;BRF1
    Interleukin-11 Signaling PathwayIL11;BGLAP
    Jak-STAT signaling pathwayIL11RA;MTOR;SOCS1A;IL12BA;BCL2A;SOS1;HRAS;IFNGR2;Ifna15
    Rheumatoid arthritisITGB2L;ATP6V1C2;ICAM1;HLA-DMA;MMP1A;ATP6V1B2;CXCL5;HLA-DRB3;Ccl12

    IL11 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-11 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL11 itself. We selected most functions IL11 had, and list some proteins which have the same functions with IL11. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityIFNA10;IL16;IL28A;IFNG;TGFB1;GM13289;BMP15;TNFSF8;IFNG1-1
    growth factor activityAGT;PROK1;MACC1;GDF15;CXCL1;NENF;FGF8B;LEFTY2;BMP10
    interleukin-11 receptor binding
    protein bindingMLC1;TULP1;ANP32A;MEGF6;PCDHA4;MPPE1;NTRK1;CLTB;TGFB2

    IL11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL11 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL11.

    MAGEA11; MAGEA11

    Mannam, VKR; Lewis, RE; et al. The fate of renal allografts hinges on responses of the microvascular endothelium. EXPERIMENTAL AND MOLECULAR PATHOLOGY 94:398-411(2013).
    Dams-Kozlowska, H; Gryska, K; et al. A designer hyper interleukin 11 (H11) is a biologically active cytokine. BMC BIOTECHNOLOGY 12:-(2012).
    IL
    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    How are in vivo models, including transgenic mice and knockdown strategies, utilized to study IL11's effects on tissue regeneration and homeostasis? 11/05/2022

    Transgenic mice and knockdown models explore IL11's impact on tissue regeneration.

    Could you explain the experimental approaches, such as site-directed mutagenesis, employed to identify key residues in IL11's interaction with IL11RA? 07/14/2021

    Site-directed mutagenesis identifies key residues in IL11's interaction with IL11RA.

    What techniques like chromatin immunoprecipitation and DNA methylation analysis contribute to deciphering IL11's regulatory mechanisms? 05/27/2021

    Chromatin immunoprecipitation and DNA methylation analysis decipher IL11's regulatory mechanisms.

    Can you elaborate on the role of proteomics in identifying IL11-interacting proteins and potential cross-talk with other signaling pathways? 09/28/2020

    Proteomics identifies IL11-interacting proteins and potential cross-talk partners.

    How do cell-based assays and luciferase reporter assays help investigate IL11's downstream signaling pathways through JAK-STAT activation? 05/19/2020

    Cell-based and luciferase reporter assays elucidate IL11's JAK-STAT signaling activation.

    What role does RNA sequencing play in understanding IL11-induced gene expression changes in various cell types? 02/24/2019

    RNA sequencing uncovers IL11-induced gene expression changes across different cell types.

    What structural insights have X-ray crystallography and nuclear magnetic resonance spectroscopy provided about the IL11-IL11RA complex? 01/13/2019

    X-ray crystallography and NMR spectroscopy reveal structural details of the IL11-IL11RA complex.

    How do advanced imaging techniques like confocal microscopy and super-resolution microscopy visualize IL11 localization and distribution in tissues? 11/08/2018

    Confocal and super-resolution microscopy visualize IL11 localization in tissues.

    How are techniques like surface plasmon resonance used to study IL11's binding kinetics to its receptor IL11RA? 04/17/2017

    Techniques like surface plasmon resonance measure IL11-IL11RA binding affinity and kinetics.

    What insights have CRISPR screening approaches provided regarding genes and pathways influenced by IL11 signaling? 02/06/2017

    CRISPR screening unveils genes and pathways influenced by IL11 signaling.

    Customer Reviews (3)

    Write a review
    Reviews
    10/28/2019

      Potent in bone regeneration models. -

      11/26/2017

        Suitable for cell culture. -

        01/10/2017

          High yield in expression. -

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