IL11

  • Official Full Name

    interleukin 11

  • Overview

    The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
  • Synonyms

    IL11; interleukin 11; AGIF; IL-11; interleukin-11; oprelvekin; adipogenesis inhibitory factor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Therapeutic Proteins
  • Transfected Stable Cell Lines
  • Cynomogus
  • Cynomolgus
  • Cynomolgus monkey
  • Human
  • Mouse
  • Rat
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • Human
  • Human Cells
  • Insect Cell
  • Mammalian cells
  • Mouse
  • P.pastoris
  • Sf21 Insect Cell
  • Yeast
  • C
  • Fc
  • His
  • Myc
  • His(N
  • ter)
  • His|T7
  • Avi
  • MBP
  • Met
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL11-325H Active Recombinant Human IL11 Human N/A
Human IL11-416H Active Recombinant Human Interleukin-11 Human N/A
Human IL11-953H Active Recombinant Human IL11 Protein P.pastoris N/A
Human IL11-29630TH Recombinant Human IL11 E.coli N/A
Human IL11-842H Recombinant Human IL11 protein, His & T7-tagged E.coli His/T7
Human IL11-123H Recombinant Human IL11 protein E.coli N/A
Human IL11-551H Recombinant Human Interleukin 11 Human N/A
Human IL11-464H Recombinant Human IL11, None tagged E.coli Fc
Human IL11-218H Recombinant Human Interleukin 11 Sf21 Insect Cell N/A
Human IL11-19H Recombinant Human Interleukin-11 Yeast N/A
Human IL11-503H Recombinant Human IL11 protein, His-tagged HEK293F His
Human IL11-5249HCL Recombinant Human IL11 293 Cell Lysate HEK293 N/A
Human IL11-121HG Active GMP Recombinant Human IL11 protein HEK293
Human IL11-2289H Recombinant Human IL11 Protein, His-tagged E.coli N-His
Human IL11-2016H Recombinant Human IL11 Protein, Met-tagged E.coli Met
Human IL11-4326HG Active GMP Recombinant Human IL11 protein E.coli N/A
Human IL11-061H Active Recombinant Human IL11 Protein E. coli
Human IL11-151H Recombinant Human IL11 Protein, His-tagged Human Cells His
Human IL11-P012H Recombinant Human IL11 therapeutic protein E.coli N/A
Human IL11-101HG Active GMP Recombinant Human IL11 Protein Insect Cell N/A
Human IL11-2519H Recombinant Human IL11 Protein (Pro22-Leu199), His tagged E.coli His
Human IL11-1581H Active Recombinant Human IL11 protein, Fc-tagged HEK293 Fc
Human IL11-130H Active Recombinant Human IL11 Protein E.coli
Human IL11-259I Active Recombinant Human IL11 Protein CHO
Human IL11-2597H Active Recombinant Human IL11 protein E.coli N/A
Human IL11-1582H Active Recombinant Human IL11 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
Human IL11-4299H Recombinant Human IL11 Protein (Met1-Leu199), C-His tagged Mammalian cells C-His
Human IL11-1583H Active Recombinant Human IL11 protein, His-tagged HEK293 His
Human IL11-124H Human Interleukin-11 (rDNA derived) Reference standard N/A
Human IL11-175H Active Recombinant Human IL11 Protein (Pro22-Leu199), N-His tagged, Animal-free, Carrier-free E.coli N-His
Human IL11-137H Recombinant Active Human IL11 Protein, His-tagged(N-ter) E.coli His(N-ter)
Mouse Il11-01M Active Recombinant Mouse Il11 Protein, His-Tagged E.coli His
Mouse Il11-843M Recombinant Mouse Il11 protein, His-tagged E.coli His
Mouse Il11-586M Recombinant Mouse interleukin 11 Mouse N/A
Mouse Il11-161M Recombinant Mouse Il11 protein E.coli N/A
Mouse Il11-842M Recombinant Mouse Il11 Protein E.coli N/A
Mouse Il11-1373M Recombinant Mouse Il11 protein, MBP&His-Avi-tagged, Biotinylated E.coli MBP&His-Avi
Mouse Il11-46M Active Recombinant Mouse Il11 Protein (Pro22-Leu199), N-His tagged, Animal-free, Carrier-free E.coli N-His
Mouse Il11-138M Recombinant Active Mouse IL11 Protein, His-tagged(N-ter) E.coli His(N-ter)
Mouse IL11-131M Active Recombinant Mouse IL11 Protein E.coli
Mouse Il11-085M Active Recombinant Mouse Il11 Protein E.coli
Mouse Il11-5692M Recombinant Mouse Il11 Protein (Pro22-Leu199), C-Fc tagged Mammalian cells C-Fc
Mouse Il11-039I Active Recombinant Mouse Il11 Protein (179 aa) E.coli
Mouse Il11-5693M Recombinant Mouse Il11 Protein (Pro22-Leu199), C-His tagged Mammalian cells C-His
Mouse Il11-182I Active Recombinant Mouse Il11 Protein HEK293
Mouse IL11-1579M Active Recombinant Mouse IL11 protein, Fc-tagged HEK293 Fc
Rat Il11-1375R Recombinant Rat Il11 protein, MBP&His-Avi-tagged, Biotinylated E.coli MBP&His-Avi
Rat Il11-1659R Recombinant Rat Il11 Protein, His-tagged E.coli N-His
Rat Il11-4756R Recombinant Rat Il11 protein, His&Myc-tagged E.coli His&Myc
Cynomogus IL11-938C Recombinant Cynomogus IL11 Protein E. coli
Cynomogus IL11-939C Recombinant Cynomogus IL11 Protein, His-tagged E. coli His
Cynomolgus IL11-1580C Active Recombinant Cynomolgus IL11 protein, His-tagged HEK293 His
Cynomolgus IL11-1305C Recombinant Cynomolgus IL11 protein(Phe22-Leu199) E. coli N/A
Cynomolgus monkey Il11-1374C Recombinant Cynomolgus monkey Il11 protein, MBP&His-Avi-tagged, Biotinylated E.coli MBP&His-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IL11 Related Articles
  • IL11 Related Gene Family
  • IL11 Related Research Area

IL11 involved in several pathways and played different roles in them. We selected most pathways IL11 participated on our site, such as Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Integrated Pancreatic Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCXCR3.1;CCL27B;IL24;CCL24;GM2506;TGFB2;BMP7;INHBE;TNFRSF8
Hematopoietic cell lineageItgam&Itgb2;IL11RA2;IL3RA;Flt3l;HLA-DRB4;CD1C;FCGR1A;IL4R;THPO
Integrated Pancreatic Cancer PathwayLEFTY1;RB1CC1;IL11;FST;JUND;MST1;FKBP1B;RAPGEF3;MAPK4
Interleukin-11 Signaling PathwayBGLAP;IL11
Jak-STAT signaling pathwayIL12A;STAT2;PTPN6;MPL;PTPN11B;IL15RA;CCND3;IFNB1;IFNL3
Rheumatoid arthritisITGB2;HLA-DRA;TGFB2;ATP6V0A1;HLA-DRB3;IL23;HLA-DRB1;HLA-DRB4;CXCL5

IL11 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-11 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL11 itself. We selected most functions IL11 had, and list some proteins which have the same functions with IL11. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIL11;INHBA;IFNG1-2;Ccl12;TGFB1;CMTM6;IFNA7;CMTM3;BMP15
growth factor activityCSF3;PDGFD;IL7;NOV;EGF;FGF13A;IL5;FBRS;BMP2B
interleukin-11 receptor binding
protein bindingC9orf43;DYNC1H1;PLG;NDRG1;CSNK1D;KPNA3;TP53;RPS18;MORN4

IL11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL11 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL11.

MAGEA11; MAGEA11

Mannam, VKR; Lewis, RE; et al. The fate of renal allografts hinges on responses of the microvascular endothelium. EXPERIMENTAL AND MOLECULAR PATHOLOGY 94:398-411(2013).
Dams-Kozlowska, H; Gryska, K; et al. A designer hyper interleukin 11 (H11) is a biologically active cytokine. BMC BIOTECHNOLOGY 12:-(2012).
IL
  • Q&As
  • Reviews

Q&As (10)

Ask a question
How are in vivo models, including transgenic mice and knockdown strategies, utilized to study IL11's effects on tissue regeneration and homeostasis? 11/05/2022

Transgenic mice and knockdown models explore IL11's impact on tissue regeneration.

Could you explain the experimental approaches, such as site-directed mutagenesis, employed to identify key residues in IL11's interaction with IL11RA? 07/14/2021

Site-directed mutagenesis identifies key residues in IL11's interaction with IL11RA.

What techniques like chromatin immunoprecipitation and DNA methylation analysis contribute to deciphering IL11's regulatory mechanisms? 05/27/2021

Chromatin immunoprecipitation and DNA methylation analysis decipher IL11's regulatory mechanisms.

Can you elaborate on the role of proteomics in identifying IL11-interacting proteins and potential cross-talk with other signaling pathways? 09/28/2020

Proteomics identifies IL11-interacting proteins and potential cross-talk partners.

How do cell-based assays and luciferase reporter assays help investigate IL11's downstream signaling pathways through JAK-STAT activation? 05/19/2020

Cell-based and luciferase reporter assays elucidate IL11's JAK-STAT signaling activation.

What role does RNA sequencing play in understanding IL11-induced gene expression changes in various cell types? 02/24/2019

RNA sequencing uncovers IL11-induced gene expression changes across different cell types.

What structural insights have X-ray crystallography and nuclear magnetic resonance spectroscopy provided about the IL11-IL11RA complex? 01/13/2019

X-ray crystallography and NMR spectroscopy reveal structural details of the IL11-IL11RA complex.

How do advanced imaging techniques like confocal microscopy and super-resolution microscopy visualize IL11 localization and distribution in tissues? 11/08/2018

Confocal and super-resolution microscopy visualize IL11 localization in tissues.

How are techniques like surface plasmon resonance used to study IL11's binding kinetics to its receptor IL11RA? 04/17/2017

Techniques like surface plasmon resonance measure IL11-IL11RA binding affinity and kinetics.

What insights have CRISPR screening approaches provided regarding genes and pathways influenced by IL11 signaling? 02/06/2017

CRISPR screening unveils genes and pathways influenced by IL11 signaling.

Customer Reviews (3)

Write a review
Reviews
10/28/2019

    Potent in bone regeneration models.

    11/26/2017

      Suitable for cell culture.

      01/10/2017

        High yield in expression.

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