|Official Full Name||coagulation factor III (thromboplastin, tissue factor)|
|Background||This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]|
|Synonyms||F3; coagulation factor III (thromboplastin, tissue factor); TF; TFA; CD142; tissue factor;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
f3 involved in several pathways and played different roles in them. We selected most pathways f3 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with f3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Complement and coagulation cascades||CD46; FGB; F2R; SERPINF2; C2; C1RA; SERPINA1A; CR2; MBL1; C8G|
f3 has several biochemical functions, for example, cytokine receptor activity, phospholipid binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by f3 itself. We selected most functions f3 had, and list some proteins which have the same functions with f3. You can find most of the proteins on our site.
|cytokine receptor activity||CD74; IL20RB; IL13RA1; CRFB17; IL31RA; FLT3; LIFRB; CRFB6; CRFB15; Ifnlr1|
|phospholipid binding||PICALMA; TICAM2; LRBA; PRKCI; OTC; NBEAL2; GRK5; NSFL1C; PLA2G15; BAIAP2L2|
|protease binding||TNF; Casp3; RNF139; DVL3; CSTA; ADAMTSL4; CST3; ITGB1; F3; CAST|
|protein binding||TEKT4; NR2E3; KRAS; ARMC9; PPP2R4; DOK1; ESYT1; KRTAP9-2; RAB24; TAOK1|
f3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with f3 here. Most of them are supplied by our site. Hope this information will be useful for your research of f3.