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EPO

  • Official Full Name

    erythropoietin

  • Overview

    This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]
  • Synonyms

    EPO; erythropoietin; EP; MVCD2; epoetin;

  • Recombinant Proteins
  • GMP Proteins
  • Therapeutic Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Assay Kits
  • Bovine
  • Canine
  • Cynomolgus
  • Cynomolgus monkey
  • Dog
  • Equine
  • Horse
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Rhesusmacaque
  • Zebrafish
  • CHO
  • CHO-K1
  • E.coli
  • HEK293
  • HEK293F
  • Human
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Insect cells
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • Fc
  • His
  • GST
  • hFc
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • His|S
  • His|T7
  • B2M
  • SUMO
  • N/A
  • N
  • MBP
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EPO-234H Active Recombinant Human EPO, Fc-tagged CHO Fc
Human EPO-001H Active Recombinant Human EPO, MIgG2a Fc-tagged CHO Fc
Human EPO-002H Active Recombinant Human EPO, HIgG1 Fc-tagged, mutant CHO Fc
Human EPO-111H Active Recombinant Human EPO, HIgG1 Fc-tagged CHO Fc
Human EPO-269H Active Recombinant Human Erythropoietin Human N/A
Human EPO-363H Active Recombinant Human EPO Protein, His-tagged Insect Cell His
Human EPO-163H Active Recombinant Human Erythropoietin HEK293 N/A
Human EPO-01HG Active GMP Recombinant Human EPO Protein CHO-K1
Human EPO-124E Active Recombinant Human EPO alpha Protein (165 aa) CHO 165
Human EPO-589H Active Recombinant Human EPO Protein Tag Free
Human EPO-01H Recombinant Human Erythropoietin Mammalian Cell N/A
Human EPO-2291H Recombinant Human EPO, His-tagged E.coli His 189aa
Human EPO-3423H Recombinant Human EPO Protein, GST-tagged Wheat Germ GST
Human EPO-252H Recombinant Human EPO, StrepII-tagged Human Cell Strep II 28-193, 166 a.a.
Human EPO-513H Recombinant Human EPO protein CHO N/A 166
Human EPOR-1614H Recombinant Human Erythropoietin Receptor Mammalian cells N/A
Human EPO-451H Recombinant Human EPO protein, His-tagged HEK293F His Ala28~Arg193
Human EPO-97H Recombinant Human EPO protein,Fc-tagged CHO Fc
Human EPO-517H Recombinant Human EPO protein HEK293 166
Human EPO-200H Active Recombinant Human EPO protein, hFc-tagged HEK293 hFc Met1-Arg193
Human EPO-602H Recombinant Human EPO protein, His & GST-tagged E.coli His/GST Ala28~Arg193 (Accession # P01588)
Human EPO-P011H Recombinant Human EPO therapeutic protein CHO N/A 166 Aa
Human EPO-355H Recombinant Human EPO protein HEK293 166
Human EPO-323HG Active GMP Recombinant Human EPO protein HEK293 DNA sequence encoding Human EPO(NP_000790.2) was expressed with His tag at the C-terminal.
Human EPO-1020H Recombinant Human EPO protein HEK293 N/A Ala 28 - Arg 193
Human EPO-08H Active Recombinant Human EPO Protein, Animal Free Human cells
Human EPO-289E Active Recombinant Human EPO Protein (166 aa) CHO 166
Human EPO-41H Recombinant Erythropoietin Reference standard N/A
Human EPO-4401HF Recombinant Full Length Human EPO Protein, GST-tagged In Vitro Cell Free System GST 193 amino acids
Human EPO-487H Recombinant Human EPO Protein 193
Human EPO-4083H Recombinant Human EPO Protein (Met1-Arg193), C-Fc tagged Mammalian cells C-Fc Met1-Arg193
Human EPO-4401H Recombinant Human EPO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EPO-2525H Recombinant Human EPO Protein (Val3-Arg193), N-His tagged E.coli N-His Val3-Arg193
Human EPO-2524H Recombinant Human EPO Protein (Ala28-Arg193), N-His tagged E.coli N-His Ala28-Arg193
Human EPO-4086H Recombinant Human EPO Protein (Ala28-Arg193), C-Fc tagged Mammalian cells C-Fc Ala28-Arg193
Human EPO-4401H-B Recombinant Human EPO Protein Pre-coupled Magnetic Beads HEK293
Human EPO-2521H Recombinant Human EPO protein(28-193 aa), N-MBP-His-tagged HEK293 N-MBP-His 28-193 aa
Human EPO-4085H Recombinant Human EPO Protein (Ala28-Arg193), C-His tagged Mammalian cells C-His Ala28-Arg193
Mouse Epo-966M Active Recombinant Mouse Epo Protein HEK293 N/A
Mouse Epo-603M Recombinant Mouse Epo protein, His & S-tagged E.coli His/S Val82~Arg192 (Accession # P07321)
Mouse Epo-173M Recombinant Mouse Erythropoietin Mammalian cells N/A
Mouse Epo-604M Recombinant Mouse Epo protein, His & T7-tagged E.coli His/T7 Val82~Arg192 (Accession # P07321)
Mouse Epo-7421M Active Recombinant Mouse Epo protein, His-tagged HEK293 His Met1-Arg192
Mouse EPO-1450MCL Recombinant Mouse EPO cell lysate Human Cell N/A
Mouse Epo-4376M Recombinant Mouse Epo Protein Yeast N/A 165aa
Mouse Epo-964M Active Recombinant Mouse Epo Protein CHO
Mouse Epo-022M Active Recombinant Mouse Epo Protein, His-tagged Insect cells His
Mouse Epo-1847M Recombinant Mouse Epo Protein CHO N/A
Mouse Epo-10549M Recombinant Mouse Epo Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Epo-10549M-B Recombinant Mouse Epo Protein Pre-coupled Magnetic Beads HEK293
Mouse Epo-1433M Recombinant Mouse Epo Protein, His&GST-tagged E.coli N-His&GST Val82-Arg192
Rat EPO-578R Active Recombinant Rat EPO, His-tagged Insect cells His Met 1-Arg 192
Rat Epo-606R Recombinant Rat Epo protein, His & T7-tagged E.coli His/T7 Pro28~Arg192 (Accession # P29676)
Rat Epo-523R Recombinant Rat Epo Protein(Pro28~Arg192), His-tagged HEK293 N-His Pro28~Arg192
Rat EPO-2127R Recombinant Rat EPO Protein Mammalian Cell His
Rat EPO-592RCL Recombinant Rat EPO cell lysate Insect Cell N/A
Rat EPO-1784R-B Recombinant Rat EPO Protein Pre-coupled Magnetic Beads HEK293
Rat Epo-01R Active Recombinant Rat Epo protein, His-tagged HEK293 His
Rat EPO-1784R Recombinant Rat EPO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Epo-1848R Recombinant Rat Epo Protein CHO N/A
Rhesus monkey EPO-1432R Recombinant Rhesus monkey EPO Protein, His-tagged E.coli N-His Ala28-Arg193
Dog EPO-904D Recombinant Dog EPO Protein, His-tagged E.coli N-His Ala41-Arg206
Dog EPO-3276D Recombinant Dog EPO protein, His-tagged HEK293 His Ala41~Arg206
Bovine EPO-4368B Recombinant Bovine EPO Protein Yeast N/A 167aa
Bovine EPO-5395B Recombinant Bovine EPO protein, His-tagged Yeast His 26-192aa
Bovine EPO-2858B Recombinant Bovine EPO protein, His-SUMO-tagged E.coli His-SUMO 26-192aa
Canine Epo-104C Recombinant Canine Erythropoietin Yeast N/A
Cynomolgus EPO-1196C Active Recombinant Cynomolgus EPO protein(Met1-Arg192), His-tagged HEK293 C-His Met1-Arg192
Cynomolgus monkey EPO-5397C Recombinant Cynomolgus monkey EPO protein, His-tagged Yeast His 28-192aa
Cynomolgus monkey EPO-2861C Recombinant Cynomolgus monkey EPO protein, His-SUMO-tagged E.coli His-SUMO 28-192aa
Equine EPO-100E Recombinant Equine EPO Yeast N/A
Horse EPO-2860H Recombinant Horse EPO protein, His-SUMO-tagged E.coli His-SUMO 27-192aa
Horse EPO-4237H Recombinant HorseEPO protein, His&Myc-tagged Insect Cell His&Myc 27-192aa
Horse EPO-4239H Recombinant Horse EPO protein, hFc-tagged Mammalian cell hFc 27-192aa
Horse EPO-4238H Recombinant Horse EPO protein, His-tagged Yeast His 27-192aa
Rhesus Macaque EPO-1487R Recombinant Rhesus monkey EPO Protein, His-tagged Mammalian Cell His
Rhesus Macaque EPO-1312R-B Recombinant Rhesus Macaque EPO Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EPO-1312R Recombinant Rhesus Macaque EPO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesusmacaque EPO-5010R Recombinant Rhesusmacaque EPO protein, His-tagged HEK293 His 28-192aa
Zebrafish EPO-3602Z Recombinant Zebrafish EPO Mammalian Cell His
Zebrafish epo-5396Z Recombinant Zebrafish epo protein, His-tagged Yeast His 24-183aa
Zebrafish epo-2859Z Recombinant Zebrafish epo protein, His-tagged E.coli His 24-183aa
Pig EPO-605P Recombinant Pig EPO protein, His & GST-tagged E.coli His/GST Ala27~Arg194 (Accession # P49157)
Pig EPO-1203P Recombinant Pig EPO Protein, His-tagged Yeast His
Pig EPO-104S Recombinant Swine EPO Yeast N/A
Pig EPO-2862P Recombinant Pig EPO protein, His-B2M-tagged E.coli His-B2M 27-194aa
Pig EPO-5011P Recombinant Pig EPO protein, His-tagged HEK293 His 27-194aa
Kit-0327 Eosinophil Peroxidase Fluorometric Detection Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • EPO Related Signal Pathway

EPO involved in several pathways and played different roles in them. We selected most pathways EPO participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCCL5;IFNA2;IL11RA;CSF1RA;VEGFC;CXCR4A;TNFRSF1B;IL29;TNFRSF12A
HIF- signaling pathwayERBB2;VEGFA;ARNT;CUL2;PDHB;TCEB1;IL6R;HKDC1;AKT2
PIK-Akt signaling pathwayGYS1;MTCP1;PIK3R5;HSP90B1;IL6R;PPP2R2D;YWHAB;IFNA14;IFNA17
Jak-STAT signaling pathwayPRLR;PIAS4B;CCND3;AOX2P;AOX4;Il4ra;IL22RA2;TYK2;PRL
Hematopoietic cell lineageKitl;GP1BA;IL11RA2;CSF3;CD38;CD1B;CD3E; CD3D;CR1;GP1BB

EPO has several biochemical functions, for example, erythropoietin receptor binding, hormone activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPO itself. We selected most functions EPO had, and list some proteins which have the same functions with EPO. You can find most of the proteins on our site.

Function Related Protein
erythropoietin receptor bindingRNF41;EPO
hormone activityPRL;NPPB;AMH;POMCB;PRL7A1;INHBC;PRL7A2;TSHB;INSL6
protein bindingTTC30B;KIAA1279;SAP30;PML;RSPH9;RAD51C;RPLP0;HIST1H1A;SOX10
protein kinase activator activityDAXX;MARK2;DBF4B;CAB39;TOM1L1;NKX3-1;FAM58A;GPRC5B;STK11

EPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPO here. Most of them are supplied by our site. Hope this information will be useful for your research of EPO.

EPOR; DOK2; EP300

Research Area

Related articles

Wiedenmann, T; Ehrhardt, S; et al. Erythropoietin acts as an anti-inflammatory signal on murine mast cells. MOLECULAR IMMUNOLOGY 65:68-76(2015).
Fatemi, MJ; Emami, AH; et al. Effects of Recombinant Human Erythropoietin on Revascularization of Full Thickness Skin Grafts in Rat. IRANIAN RED CRESCENT MEDICAL JOURNAL 16:-(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the relationship between EPO protein and cardiovascular disease? 08/05/2019

EPO protein can promote the renewal and repair of heart blood vessels, and has the effect of protecting the heart from ischemia-reperfusion damage.

How does EPO protein regulate erythropoiesis? 07/12/2019

By binding to receptors, EPO proteins activate signaling pathways that promote the proliferation and differentiation of hematopoietic stem cells in bone marrow into erythrocytes.

How about the clinical use of EPO protein? 06/12/2019

EPO protein can be used by injection or oral, and the specific method and dosage need to be determined according to the condition and the doctor's advice.

What are the implications of EPO protein research for the future of treating anemia? 05/14/2019

The study of EPO protein helps to understand the regulatory mechanism of erythropoiesis and provides new ideas and methods for the treatment of anemia, such as developing more effective EPO protein analogues or improving existing treatment regimens.

How is EPO protein treated for anemia? 05/02/2019

This protein stimulates the bone marrow to produce more red blood cells, thereby increasing hemoglobin levels and treating anemia.

What is the role of EPO protein in kidney disease? 04/04/2019

In kidney disease, due to impaired kidney function, the production of EPO protein decreases, leading to anemia. Supplementation with exogenous EPO protein can help correct anemia caused by kidney problems.

Customer Reviews (3)

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Reviews
12/28/2021

    Stability is truly remarkable, can maintain its activity even under extreme conditions.

    08/31/2021

      Can catalyze reactions even under extreme conditions.

      02/03/2019

        This protein's repeatability is truly exceptional, consistently delivering reliable results even under challenging conditions.

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