Downstream Processing Development

Downstream Processing Development

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Downstream Processing Development

Downstream processing is the recovery and purification of biopharmaceuticals. It is an essential step in the manufacture of recombinant biotherapeutics, which follows the upstream processing, also called fermentation. In the development of downstream processes, the structural and functional parameters of the recombinant protein must be retained while simultaneously all potential contaminants are removed.

Creative BioMart partners with our clients to develop and optimize the downstream conditions that are necessary to deliver high yields of stable therapeutic and vaccine products. Creative BioMart will pull upon past experience, and knowledge of best practices in the field to deliver a process that meets the necessary production, quality, and regulatory requirements of the product. Our downstream development goal is to use purification technologies that are commercially available, cost effective, and will meet product specifications for quantity, purity and potency. Creative BioMart offers entire processing service of downstream development, including removal of insolubles, product isolation, product purification and product polishing. Upon completion of every process development program Creative BioMart provides a detailed report explaining the processes evaluated during development, the final process selected, and criteria for selection of the final process.

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