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Official Full Name coagulation factor VIII, procoagulant component
Background Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII is encoded by the F8 gene. Defects in this gene results in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver sinusoidal cells and endothelial cells outside of the liver throughout the body. This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs. In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. This interaction sets off a chain of additional chemical reactions that form a blood clot.
Synonyms Factor VIII; FVIII; F8; coagulation factor VIII, procoagulant component; AHF; F8B; F8C; HEMA; FVIII; DXS1253E; coagulation factor VIII; factor VIII F8B; antihemophilic factor; coagulation factor VIIIc
    • Species :
    • Dog
    • Human
    • Mouse
    • Pig
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Plasma
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human F8-048H Recombinant Human F8 Protein, His-tagged E.coli His
    Human F8-125H Recombinant Human Coagulation Factor VIII, Procoagulant Component CHO N/A
    Human F8-12626H Recombinant Human F8, His-tagged E.coli His
    Human F8-126H Recombinant Human F8, GST-tagged Wheat Germ N/A
    Human F8-2397H Recombinant Human Coagulation Factor VIII, Procoagulant Component E.coli N/A
    Human F8-25H Human Blood Coagulation Factor VIII Reference standard N/A
    Human F8-3065H Human Factor-VIII Human Plasma N/A
    Human F8-3624H Recombinant Human F8 Protein, GST-tagged Wheat Germ GST
    Human F8-38H Human Factor VIII Reference standard N/A
    Human F8-6482HCL Recombinant Human F8 293 Cell Lysate HEK293 N/A
    Human F8-P037H Recombinant Human F8 therapeutic protein CHO N/A
    Mouse F8-1921M Recombinant Mouse F8 protein, His-tagged E.coli His
    Dog F8-1920D Recombinant Dog F8 protein, His-tagged E.coli His
    Pig F8-1922P Recombinant Pig F8 protein, His-tagged E.coli His

    f8 involved in several pathways and played different roles in them. We selected most pathways f8 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with f8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades LOC100514666; F11; F12; CFH; Serpina1b; CD46; SERPINF2; THBD; GM5077; CPB2

    f8 has several biochemical functions, for example, copper ion binding, oxidoreductase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by f8 itself. We selected most functions f8 had, and list some proteins which have the same functions with f8. You can find most of the proteins on our site.

    Function Related Protein
    copper ion binding SCO2; F8; LOXL5B; HEPH; S100A5; RNF7; HAMP; ATP7A; S100A13; SERPINB1A
    oxidoreductase activity CYP46A1.1; HSD3B6; CYP2K17; CYP4F18; RETSAT; AKR1CL1; CYP2K6; PDHA1B; RDH7; RDH1
    protein binding FBXL3; HER11; BBS1; NR2C2; ARRB1; CWC15; NR2F2; AZU1; FBXL19; USP14

    f8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with f8 here. Most of them are supplied by our site. Hope this information will be useful for your research of f8.

    kv312_human; EIF1B; CALR; GGA1; UBQLN1; MAP1LC3A

    Anderson, DR; Cameron, AC; et al. WASP-20b and WASP-28b: a hot Saturn and a hot Jupiter in near-aligned orbits around solar-type stars. ASTRONOMY & ASTROPHYSICS 575:-(2015).
    Hashemi, SM; Fischer, K; et al. Improved prediction of inhibitor development in previously untreated patients with severe haemophilia A. HAEMOPHILIA 21:227-233(2015).

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