|Official Full Name||coagulation factor VIII, procoagulant component|
|Background||Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII is encoded by the F8 gene. Defects in this gene results in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver sinusoidal cells and endothelial cells outside of the liver throughout the body. This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs. In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. This interaction sets off a chain of additional chemical reactions that form a blood clot.|
|Synonyms||Factor VIII; FVIII; F8; coagulation factor VIII, procoagulant component; AHF; F8B; F8C; HEMA; FVIII; DXS1253E; coagulation factor VIII; factor VIII F8B; antihemophilic factor; coagulation factor VIIIc|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
f8 involved in several pathways and played different roles in them. We selected most pathways f8 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with f8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Complement and coagulation cascades||LOC100514666; F11; F12; CFH; Serpina1b; CD46; SERPINF2; THBD; GM5077; CPB2|
f8 has several biochemical functions, for example, copper ion binding, oxidoreductase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by f8 itself. We selected most functions f8 had, and list some proteins which have the same functions with f8. You can find most of the proteins on our site.
|copper ion binding||SCO2; F8; LOXL5B; HEPH; S100A5; RNF7; HAMP; ATP7A; S100A13; SERPINB1A|
|oxidoreductase activity||CYP46A1.1; HSD3B6; CYP2K17; CYP4F18; RETSAT; AKR1CL1; CYP2K6; PDHA1B; RDH7; RDH1|
|protein binding||FBXL3; HER11; BBS1; NR2C2; ARRB1; CWC15; NR2F2; AZU1; FBXL19; USP14|
f8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with f8 here. Most of them are supplied by our site. Hope this information will be useful for your research of f8.
kv312_human; EIF1B; CALR; GGA1; UBQLN1; MAP1LC3A