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SPAM1

  • Official Full Name

    sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)

  • Overview

    Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement;membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3;and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol;SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme;located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that;enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that;plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida;adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes;leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for;this gene.
  • Synonyms

    SPAM1; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); sperm adhesion molecule 1; HYA1; HYAL PH-20; HYAL PH20; Hyal-PH20; HYAL1; HYAL3; HYAL5; HYALP_HUMAN; Hyaluronidase PH-20; Hyaluronoglucosaminidase PH-20; MGC26532; PH-20 Hyaluronidase; PH20; PH20 Hyaluronidase; SPAG15; SPAM-1; Sperm surface protein PH-20; Sperm surface protein PH20; zona pellucida binding; hyaluronidase, zona pellucida binding; PH-20;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Myc
  • DDK
  • Fc
  • Fc|His
  • Flag
  • His (Fc)
  • Avi
  • His|Fc
  • His|SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SPAM1-P1004H Active Recombinant Human SPAM1 / PH20 / Hyaluronidase protein, Tag Free CHO N/A
Human SPAM1-738H Active Recombinant Human SPAM1 protein, His-tagged HEK293 His Leu 36 - Tyr 482
Human SPAM1-1532H Recombinant Human SPAM1, His-Fc-tagged Human His/Fc
Human TNFSF11-313H Recombinant Human Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding), His-Fc-Tagged Human Fc/His
Human SPAM1-1546HCL Recombinant Human SPAM1 293 Cell Lysate HEK293 N/A
Human SPAM1-1530H Active Recombinant Human SPAM1 protein, Fc-tagged CHO Fc
Human SPAM1-1383H Recombinant Human SPAM1 protein, His-tagged E.coli His 36-490aa
Human SPAM1-1187H Recombinant Human SPAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SPAM1-2080H-B Recombinant Human SPAM1 Protein Pre-coupled Magnetic Beads HEK293
Human SPAM1-15H Recombinant Human SPAM1 Protein, C-Myc/DDK-tagged HEK293T C-Myc/DDK
Human SPAM1-01H Recombinant Human SPAM1 Protein, C-Myc/DDK-tagged HEK293T C-Myc/DDK
Human SPAM1-2080H Recombinant Human SPAM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SPAM1-6340H Recombinant Human SPAM1 Protein (Leu36-Ser490), C-His tagged Mammalian cells C-His Leu36-Ser490
Human SPAM1-868HFL Recombinant Full Length Human SPAM1 Protein, C-Flag-tagged Mammalian cells Flag
Human SPAM1-817H Recombinant Human SPAM1 Protein (36-490 aa), His-SUMO-tagged E.coli His/SUMO 36-490 aa
Human SPAM1-805H Recombinant Human SPAM1 Protein HEK293 509
Mouse SPAM1-15816M Recombinant Mouse SPAM1 Protein Mammalian Cell His
Mouse SPAM1-8607M Recombinant Mouse SPAM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SPAM1-8607M-B Recombinant Mouse SPAM1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Spam1-2092M Recombinant Mouse Spam1 Protein, His-tagged E.coli N-His Val36-Cys464
Rat SPAM1-5682R Recombinant Rat SPAM1 Protein Mammalian Cell His
Rat SPAM1-5341R Recombinant Rat SPAM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SPAM1-5341R-B Recombinant Rat SPAM1 Protein Pre-coupled Magnetic Beads HEK293
Rat Spam1-2091R Recombinant Rat Spam1 Protein, His-tagged E.coli N-His Val36-Cys464
Bovine SPAM1-358B Active Recombinant Bovine SPAM1, His-tagged CHO His
Zebrafish SPAM1-5156Z Recombinant Zebrafish SPAM1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SPAM1 involved in several pathways and played different roles in them. We selected most pathways SPAM1 participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycosaminoglycan degradationHPSE;HYAL1;GLB1;GNSA;GNSB;HGSNAT;GUSB;IDUA;GNS
Metabolic pathwaysITPK1A;ackA;HMGCRA;PMM1;HSD17B1;CAD;ENO2;CHKA;UQCRB

SPAM1 has several biochemical functions, for example, hyalurononglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPAM1 itself. We selected most functions SPAM1 had, and list some proteins which have the same functions with SPAM1. You can find most of the proteins on our site.

Function Related Protein
hyalurononglucosaminidase activityHYAL2;HYAL1;CD44;SPAM1;KIAA1199;HYAL6;MGEA5;HYAL4;HYAL3

SPAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPAM1.

hyaluronan

Research Area

Related articles

Blondeau, JJC; Deng, M; et al. Identification of novel long non-coding RNAs in clear cell renal cell carcinoma. CLINICAL EPIGENETICS 7:-(2015).
Yoon, S; Chang, KT; et al. Characterization of pig sperm hyaluronidase and improvement of the digestibility of cumulus cell mass by recombinant pSPAM1 hyaluronidase in an in vitro fertilization assay. ANIMAL REPRODUCTION SCIENCE 150:107-114(2014).
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