Host Cell Protein Mitigation

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Host Cell Protein Mitigation

Recombinant protein drug products are often contaminated with proteins from the host cell system from which they were derived. Called host cell proteins (HCP), these contaminating proteins often co-purify along with the therapeutic protein from its growth media. There are thousands of HCP variants, and while some may not be deleterious others can reduce drug efficacy or cause immunologic responses in patients during clinical investigation, which can halt the progress of a promising drug candidate. Creative BioMart offers an all-in-one solution to biotherapeutics manufacturers to solve their HCP challenges. We develop and run the methods, interpret the data and recommend process changes to mitigate HCP contamination in recombinant biotherapeutics.

Host Cell Protein Mitigation

Available methods include:

A myriad of methods are available to assist in the identification and quantitation of HCPs in a sample. However, due to the complexities involved in sample analysis multiple techniques must be used in concert in order to get a complete picture. What’s more, the expertise to not only develop and execute, but also to interpret the results from, the variety of analytical methods often does not exist under one roof. This is where Creative BioMart can help.

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