Drug Analysis Service
Creative BioMart provides drug analysis service for pre-clinical drugs and natural products on their physical and chemical properties. Our services include three main assays: pre-clinical pharmaceutical property analysis, pharmacokinetics analysis & bioanalysis, and natural product analysis.
Our pre-clinical pharmaceutical property analysis service aims at identifying compound impurities, evaluating packages, and providing other quality tests and methodology establishment. Impurities stand for the substances with no therapeutic function in the drugs. They can be toxic to human, or nontoxic but affect the stability and efficiency of drugs. Impurities can be introduced through the production process (intermediate, by-product, etc.) or during storage (humidity, temperature, etc.). We can accurately determine whether impurities exceed the impurity limit of drugs, thereby ensuring drug safety. We can also perform stress test, acceleration test, and long-term test to determine the potential feasibility of target drugs for clinical application.
Pharmacokinetics analysis & bioanalysis includes two parts: in vitro absorption, distribution, metabolism and elimination analysis, and in vivo metabolism and dynamics analysis. We can help you determine kinetic constants such as logD and pKa, understand metabolic process (by identification of metabolites, determination of metabolic enzyme phenotype, etc.) and conduct animal experiment on rodents to evaluate in vivo drug absorption and distribution.
Natural product analysis services include component identification, metabolomics analysis and establishment of methodologies, to help you gain a better understanding of the composition and potential therapeutic effect of natural products.
Pre-clinical pharmaceutical property analysis service items and methods
|Confirmation of compound structure||
|Separation, purification, identification and structural explanation of toxic impurities and degradation products||
|Standard reference material calibration||
|Drug content measurement and analysis methodology establishment and validation||
|Genotoxic impurities content measurement and analysis methodology establishment and validation||
|Residual solvent analysis methodology establishment and validation||
|Package and container selection||
Pharmacokinetics analysis & Bioanalysis service items and methods
|Bioanalysis||Single component or multi-component bioanalytical methodology establishment||
|Entire of partial bioanalysis method validation|
|Pharmacokinetics in vitro sample analysis|
|Pharmacokinetics in vivo sample analysis|
|Clinical sample analysis|
|In vitro absorption, distribution, metabolism and elimination study||Determination of log D and pKa||
|Chemical stability & plasma stability analysis|
|Interspecific plasma protein binding capacity test|
|PAMPA permeability evaluation|
|Interspecific biological metabolism stability analysis|
|Determination of metabolic enzyme phenotype|
|CYP450 inhibition and induction analysis|
|In vivo metabolism and dynamics study||Interspecific basic pharmacokinetics study||
|Rodent target organ absorption and distribution study|
|Material balance study|
|Metabolite identification (phase I and phase II metabolism)|
Natural product analysis service items and methods
|Natural product component identification||HRMS: Waters XevoG2-S Q-TOF|
|Natural product multi-component simultaneous quantification analysis method establishment, methodology validation and content detection||
|Multi-component blood drug concentration test, methodology establishment, methodology validation and content detection||
|Natural product metabolite study||Waters Xevo G2-S Q-TOF|
|Natural product metabolomics study||Waters Xevo G2-S Q-TOF|
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