CD3E

  • Official Full Name

    CD3e molecule, epsilon (CD3-TCR complex)

  • Overview

    The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
  • Synonyms

    CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell antigen receptor complex, epsilon subunit o; T3E; TCRE; IMD18; T-cell antigen receptor complex,;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chromatography Reagents
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Cynomolgus
  • Cynomolgus monkey
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Monkey
  • Mouse
  • Ovis aries (Sheep)
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Western lowland gorilla
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • Fc
  • Avi
  • His
  • Twin
  • Strep
  • DDK|His
  • Fc\Avi
  • Flag
  • mFc
  • Flag|Fc|His
  • FLAG
  • GST
  • hFc
  • His (Fc)
  • flag
  • His|Avi
  • His|Fc
  • His|Fc|Flag
  • His|Flag
  • His|human|IgG1|Fc
  • human|IgG1|Fc
  • Human|IgG1|Fc
  • Llama|IgG2b|Fc
  • mFC
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD3E&CD3D-182H Active Recombinant Human CD3E&CD3D, His-Fc&Flag-Fc tagged HEK293 Flag/Fc/His
Human CD3E & CD3G-251H Active Recombinant Human CD3E & CD3G protein, Flag & mFc-tagged HEK293 Flag & mFc
Human CD3E-576H Active Recombinant Human CD3E, Fc-tagged Human Cell Fc
Human CD3E-276H Active Recombinant Human CD3E protein, Fc-tagged, Biotinylated HEK293 Fc
Human CD3E & CD3G-342H Active Recombinant Human CD3E & CD3G protein, His & Fc & Flag-tagged HEK293 His/Fc/Flag
Human CD3E & CD3D-375H Active Recombinant Human CD3E & CD3D protein, His & Flag-tagged, Biotinylated HEK293 His & Flag
Human CD3E & CD3D-376H Active Recombinant Human CD3E & CD3D protein, His-tagged HEK293 His
Human CD3E & CD3D-377H Active Recombinant Human CD3E & CD3D Protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
Human CD3E-213H Active Recombinant Human CD3E protein, His-tagged HEK293 His
Human CD3E&CD3D-219H Active Recombinant Human CD3E&CD3D, His&flag-tagged HEK293 His&flag
Human CD3E-26926TH Recombinant Human CD3E Wheat Germ N/A
Human CD3E-2195H Recombinant Human CD3E protein, Strep-tagged HEK293 Strep
Human CD3E-0803H Recombinant Human CD3E Protein, GST-Tagged Wheat Germ GST
Human CD3E-829H Recombinant Human CD3E Protein, DDK/His-tagged HEK293 DDK/His
Human CD3E-2194H Recombinant Human CD3E, His tagged HEK293 His
Human CD3E-7071H Recombinant Human CD3E, His-tagged E.coli His
Human CD3E-275H Recombinant Human CD3E, His-tagged, Biotinylated HEK293 His
Human CD3E-8541H Recombinant Human CD3E protein, His/Fc-tagged HEK293 His/human/IgG1/Fc
Human CD3E-10952H Recombinant Human CD3E, GST-tagged E.coli GST
Human CD3E-1275HCL Recombinant Human CD3E cell lysate Human Cell N/A
Human CD3E & CD3G-761HCL Recombinant Human CD3E & CD3G cell lysate Human Cell N/A
Human CD3D & CD3E-944HCL Recombinant Human CD3D & CD3E cell lysate Human Cell N/A
Human CD3D & CD3E-1714HCL Recombinant Human CD3D & CD3E cell lysate Human Cell N/A
Human CD3E-321H Recombinant Human CD3E Protein, His-tagged CHO His
Human CD3E-3081H Recombinant Human CD3E Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD3E & CD3G-146H Recombinant Human CD3E & CD3G protein, Fc-tagged HEK293 Fc
Human CD3E & CD3D-109H Recombinant Human CD3E & CD3D protein, hFc-tagged HEK293 hFc
Human CD3-003M CD3E & CD3D Heterodimer protein-coupled magnetic beads
Human CD3E-2193H Active Recombinant Human CD3E Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human CD3E-2192H Recombinant Human CD3E(Asp23-Asp126) Protein, C-Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi
Human CD3E-577H Recombinant Human CD3E(Gln22-Thr48) Protein, C-mFC-tagged HEK293 mFC
Human CD3E-6357H Recombinant Human CD3E Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD3E-463H Recombinant Human CD3E Protein (Met1-Asp126), His-tagged, Biotinylated CHO His
Human CD3E-2663H Recombinant Human CD3E protein, GST-tagged E.coli GST
Human CD3E-676H Recombinant Human CD3E Protein, His and C-hFc-tagged E.coli N-His and C-hFc
Human CD3E-62HF Recombinant Full Length Human CD3E Protein In Vitro Cell Free System
Human CD3E & CD3G-145H Recombinant Human CD3E & CD3G Protein, Fc-tagged HEK293 Fc
Human CD3E-675H Recombinant Human CD3E Protein, His-tagged HEK293F N-His
Human CD3E-138H Recombinant Human CD3E Protein, His-tagged, Biotinylated HEK293 His
Human CD3E-5285H Recombinant Human CD3E Protein (Met1-Asp126), C-Twin-Strep tagged Mammalian cells C-Twin-Strep
Human CD3E-5365H Recombinant Human CD3E protein, His-tagged Yeast His
Human CD3E-3174HF Recombinant Full Length Human CD3E Protein, GST-tagged In Vitro Cell Free System GST
Human CD3E-141H Recombinant Human CD3E Protein, His-tagged HEK293 His
Human CD3E-204H Recombinant Human CD3E Protein, Fc\Avi-tagged Human Cell Fc\Avi
Human CD3E-143H Recombinant Human CD3E Protein, Strep-tagged HEK293 Strep
Human CD3E-169H Recombinant Human CD3E Protein, C-His-tagged E.coli C-His
Human CD3E-142H Recombinant Human CD3E Protein, His and Fc-tagged HEK293 His and Fc
Human CD3E-1448H Recombinant Human CD3E Protein (Met1-Asp126), C-His tagged Mammalian cells C-His
Human CD3E-3082H Active Recombinant Human CD3E protein, mFc-tagged HEK293 mFc
Human CD3E-32H Recombinant Human CD3E Protein, C-Fc-Avi tagged, Biotinylated Human Cell C-Fc-Avi
Human CD3E-0876M Active CD3E protein-coupled magnetic Beads HEK293
Mouse Cd3e-374M Recombinant Mouse Cd3e protein, Fc-tagged HEK293 human/IgG1/Fc
Mouse Cd3E&D-307M Recombinant Mouse Cd3e&Cd3d, His&Flag tag " Human Cell His/Flag
Mouse CD3D & CD3E-1076MCL Recombinant Mouse CD3D & CD3E cell lysate Human Cell N/A
Mouse CD3D & CD3E-1726MCL Recombinant Mouse CD3D & CD3E cell lysate Human Cell N/A
Mouse CD3E-1085M Recombinant Mouse CD3E Protein (Met1-Asp108), His-Fc-tagged, Biotinylated HEK293 His/Fc
Mouse Cd3e-5366M Recombinant Mouse Cd3e protein, His-tagged Yeast His
Mouse CD3E & CD3D-401M Recombinant Mouse CD3E & CD3D protein, hFc-tagged HEK293 hFc
Mouse CD3E-144M Recombinant Mouse CD3E Protein, Fc-tagged HEK293 Fc
Mouse Cd3e-839M Recombinant Mouse Cd3e Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CD3E-039M CD3E protein-coupled magnetic MicroBeads
Mouse Cd3e-674M Recombinant Mouse Cd3e Protein, His&GST-tagged E.coli N-His&GST
Mouse CD3E-2180M Recombinant Mouse CD3E protein, hFc-tagged HEK293 hFc
Rat CD3e-1115R Recombinant Rat CD3e Protein, Fc-tagged HEK293 Fc
Monkey CD3E-30H Recombinant Human CD3E Protein (198 AA), C-Fc-tagged HEK293 C-Fc
Canine CD3E-1055C Recombinant Canine CD3E Protein, Fc-tagged HEK293 Fc
Canine CD3E-3081C Recombinant Canine CD3E protein, His-tagged HEK293 His
Canis lupus familiaris (Dog) (Canis familiaris) RFL27268CF Recombinant Full Length Dog T-Cell Surface Glycoprotein Cd3 Epsilon Chain(Cd3E) Protein, His-Tagged E.coli expression system His
Cynomolgus CD3E-113C Active Recombinant Cynomolgus CD3E, His-tagged HEK293 His
Cynomolgus CD3E-199C Recombinant Cynomolgus CD3E protein, His/Fc-tagged HEK293 His/human/IgG1/Fc
Cynomolgus CD3E-274C Active Recombinant Cynomolgus CD3E, His-tagged, Biotinylated HEK293 His
Cynomolgus CD3E&CD3D-209C Recombinant Cynomolgus CD3E&CD3D protein, FLAG-Fc-tagged HEK293 FLAG-Fc
Cynomolgus CD3E-163C Recombinant Cynomolgus CD3E protein, His-tagged HEK293 His
Cynomolgus CD3E & CD3G-2045C Recombinant Cynomolgus CD3E & CD3G protein, hFc-tagged HEK293 hFc
Cynomolgus CD3E&CD3G-221C Recombinant Cynomolgus CD3E & CD3G protein, Fc-tagged HEK293 Human/IgG1/Fc
Cynomolgus CD3E & CD3D-203C Recombinant Cynomolgus CD3E & CD3D protein, hFc-tagged HEK293 hFc
Cynomolgus CD3E&CD3G-222C Recombinant Cynomolgus CD3E & CD3G protein, Fc-tagged HEK293 Llama/IgG2b/Fc
Cynomolgus CD3E-0249C Recombinant Cynomolgus CD3E protein, Fc -tagged HEK293 Fc
Cynomolgus Monkey CD3E-306C Recombinant Cynomolgus CD3D & CD3E, His-Fc & Flag-Fc tagged Human Cell Fc
Cynomolgus Monkey CD3E&CD3D-220C Recombinant Cynomolgus CD3E&CD3D, His-Fc&Flag-Fc tagged HEK293 Flag/Fc/His
Cynomolgus Monkey CD3E-390C Recombinant Cynomolgus CD3E Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CD3E&CD3D-187C Recombinant Cynomolgus CD3E&CD3D, His & flag-tagged HEK293 His/Flag
Cynomolgus Monkey CD3D & CD3E-1179CCL Recombinant Cynomolgus CD3D & CD3E cell lysate Human Cell N/A
Cynomolgus Monkey CD3E-1602CCL Recombinant Cynomolgus CD3E cell lysate Human Cell N/A
Cynomolgus Monkey CD3E-138C Recombinant Cynomolgus Monkey CD3E Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus monkey CD3E-139C Recombinant Cynomolgus monkey CD3E Protein, His-tagged HEK293 His
Cynomolgus Monkey CD3E-138C-B Recombinant Cynomolgus Monkey CD3E Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus monkey CD3E-140C Recombinant Cynomolgus monkey CD3E Protein, His and Fc-tagged HEK293 His and Fc
Homo sapiens (Human) RFL22526HF Recombinant Full Length Human T-Cell Surface Glycoprotein Cd3 Epsilon Chain(Cd3E) Protein, His-Tagged E.coli expression system His
Ovis aries (Sheep) RFL7399OF Recombinant Full Length Sheep T-Cell Surface Glycoprotein Cd3 Epsilon Chain(Cd3E) Protein, His-Tagged E.coli expression system His
Rhesus CD3E-982R Recombinant Rhesus CD3E Protein (Met1-Asp117), His-Fc-tagged HEK293 His/Fc
Rhesus Cd3e-322R Recombinant Rhesus CD3E Protein, His-tagged HEK293 His
Rhesus Macaque CD3E-1184R Recombinant Rhesus CD3E Protein, Fc-tagged HEK293 Fc
Western lowland gorilla CD3E-326W Recombinant Western lowland gorilla CD3E protein, His-tagged E.coli His
Chicken CD3E-7092C Recombinant Chicken CD3E Mammalian Cell His
Cd3E&D-309M Recombinant Mouse Cd3E&D-309M, His-Fc & Flag-Fc tag Human Cell Flag/Fc/His
CD3E&D-308H Recombinant Human CD3E & CD3D, His & Flag tag " Human Cell His/Flag
CD3E&D-310H Recombinant Human CD3D & CD3E, Flag-Fc & His-Fc tag Human Cell Flag/Fc/His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD3E Related Articles
  • CD3E Related Gene Family
  • CD3E Related Research Area

CD3E involved in several pathways and played different roles in them. We selected most pathways CD3E participated on our site, such as Hematopoietic cell lineage, T cell receptor signaling pathway, Chagas disease (American trypanosomiasis), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD3E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hematopoietic cell lineageITGA3;CD33;GM-CSF;Itgam&Itgb2;CSF3R;CD59A;CSF3;FLT3;ITGA2B
T cell receptor signaling pathwayPIK3CA;PIK3R3;IFNG;PIK3R1;PIK3CB;CBLC;OXSR1A;MAPK1;MAPK3
Chagas disease (American trypanosomiasis)TLR4;CCL3;CXCL8;MAP2K4;IKBKG;IL-8;PPP2R1B;LOC100033925;TGFBR1
MeaslesIFNA16;AKT2;IRF7;EIF2AK4;RAB9B;IFNA4;TACR1;PIK3CD;CLEC4M
HTLV-I infectionTGFB2;CDC16;HLA-DOA;ITGAL;PIK3CG;VDAC3;CRTC2;IL15;ANAPC5
Primary iCD19;ICOS;RAG2;DCLRE1C;CD8A;RAG1;CD40;LCK;CD3E
nodeficiencyCd79a, Cd79b;BTK;CD40;IL7R;CD3E;RAG2;ZAP70;ORAI1;UNG

CD3E has several biochemical functions, for example, SH3 domain binding, T cell receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD3E itself. We selected most functions CD3E had, and list some proteins which have the same functions with CD3E. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingKHDRBS3;USP8;CASP9;SH3BP5LA;SH3BP5L;SOS1;EVL;PLSCR3;EFS
T cell receptor bindingEPS8L1;CD3E;FYN;CD3G;CD1d1;DOCK2;H2-Q10;HLA-A
protein bindingFANCG;TBKBP1;CC10;SCAND1;NLGN4X;JAM2;BSCL2;PPP3R1;FLI1
protein heterodimerization activityPVRL1;DRAP1;HIST2H4A;HIST1H2AG;ITGB1;MAFG;PAFAH1B3;XBP1;ABCG8
protein kinase bindingACTA2;DLG1;MAP2K6;CCNL2;MLKL;PRKACA;SKAP1;ITGB1BP1;CACNB2
receptor signaling complex scaffold activityG3BP2;LRRK2;GRIP1;GRIP2A;SPAG9;CD3G;MAGI2;LDLRAP1;CD3E
receptor signaling protein activityCD3E;PLCG1;ADRB1;TYROBP;DOK2;TIAM2;NGF;IFITM1;ARAF
transmembrane signaling receptor activityP2RX5;ICAM1;BCAM;TLR1;SORL1;SLC22A17;SELE;CR2;Fzd4

CD3E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD3E here. Most of them are supplied by our site. Hope this information will be useful for your research of CD3E.

EPS8L1; NCK1; SYK; ZAP70

Dickson, MC; Ludbrook, VJ; et al. A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development. INFLAMMATION RESEARCH 64:171-183(2015).
Chia, LY; Walsh, NC; et al. Isolation and gene expression of haematopoietic-cell-free preparations of highly purified murine osteocytes. BONE 72:34-42(2015).
  • Q&As
  • Reviews

Q&As (5)

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Can CD3E be used to assess the effectiveness of cancer immunotherapies? 04/07/2021

Yes, CD3E levels and T-cell function can be monitored to evaluate the response to cancer immunotherapies like checkpoint inhibitors.

Are there any CD3E-targeted therapies? 06/01/2017

There are currently no approved therapies that directly target CD3E, but it is a target for research in developing immunotherapies and cancer treatments.

Are there any ongoing clinical trials involving CD3E? 12/20/2016

There may be ongoing clinical trials using CD3E-targeted therapies in the context of cancer and autoimmune diseases. It's important to check clinical trial databases for specific studies.

Can CD3E levels be used to monitor the progression of HIV? 08/27/2016

Yes, monitoring CD3E levels in HIV-infected individuals can provide valuable information about the progression of the disease and the effectiveness of antiretroviral therapy.

How is CD3E used in allergy diagnostics? 06/22/2016

CD3E can be used in research to study T-cell responses in allergic conditions, helping to better understand and diagnose allergies.

Customer Reviews (3)

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Reviews
03/22/2023

    Manufacturers with the capacity for bulk production can offer CD3E protein in larger quantities, which is advantageous for researchers working on large-scale experiments or collaborations.

    09/12/2021

      bulk production often leads to economies of scale, making the CD3E protein more cost-effective for research budgets.

      06/17/2018

        Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using CD3E protein.

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