ANO3
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Official Full Name
anoctamin 3
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Synonyms
ANO3;anoctamin 3;14004;ENSG00000134343;TMEM16C;C11orf25;GENX-3947;11p14.2;anoctamin-3;anoctamin-3;transmembrane protein 16C (eight membrane-spanning domains);
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Mouse
- Rhesus Macaque
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Mouse | Ano3-3500M | Recombinant Mouse Ano3, His-tagged | E.Coli or Yeast | His | 637 | |
Mouse | ANO3-1699M | Recombinant Mouse ANO3 Protein | Mammalian Cell | His | ||
Mouse | ANO3-569M-B | Recombinant Mouse ANO3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ANO3-569M | Recombinant Mouse ANO3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | ANO3-336R | Recombinant Rhesus monkey ANO3 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | ANO3-164R-B | Recombinant Rhesus Macaque ANO3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | ANO3-164R | Recombinant Rhesus Macaque ANO3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Chicken | ANO3-4325C | Recombinant Chicken ANO3 | Mammalian Cell | His | ||
Chicken | ANO3-4324C | Recombinant Chicken ANO3 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ANO3 Related Articles
ANO3 involved in several pathways and played different roles in them. We selected most pathways ANO3 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ion channel transport | ANO7;TCIRG1;NHEDC1;SLC17A3;CLCN5;TRDN;TRPV3;ATP8B1;TRPA1B |
Stimuli-sensing channels | CLIC2;BSND;ANO5B;ANO9;FKBP1B;UNC79;TRPM1A;CLCN6;SRI |
Transmembrane transport of small molecules | SLC24A4A;OSTM1;SLC5A8;SLC22A6;SLC6A20;SLC12A4;MCOLN2;SLC24A6;RHCGL1 |
ANO3 has several biochemical functions, for example, NOT intracellular calcium activated chloride channel activity, phospholipid scramblase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANO3 itself. We selected most functions ANO3 had, and list some proteins which have the same functions with ANO3. You can find most of the proteins on our site.
Function | Related Protein |
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NOT intracellular calcium activated chloride channel activity | Ano3;ANO8;ANO5;ANO9;ANO6;ANO7;ANO10 |
phospholipid scramblase activity | ANO4;PLSCR2;PLSCR1;PLSCR3B;ANO6;ANO7;PLSCR3A;PLSCR4;Ano3 |
ANO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANO3.
- Q&As
- Reviews
Q&As (15)
Ask a questionYes, animal models such as mice and zebrafish have been used to study the role of ANO3 in movement disorders and other physiological processes. These models help researchers understand the impact of ANO3 mutations and provide insights into potential therapeutic interventions.
ANO3 protein is mainly expressed in the brain, particularly in regions such as the neocortex, hippocampus, basal ganglia, and cerebellum. It is also found in the retina and testes, albeit at lower levels.
Yes, ANO3 protein has been implicated in movement disorders. Mutations in the ANO3 gene have been associated with autosomal dominant dystonia, a neurological disorder characterized by involuntary muscle contractions and abnormal movements.
There is currently limited information regarding the role of ANO3 protein in neurotransmitter release. While some studies have detected ANO3 expression in synaptic vesicles, further research is required to fully determine the significance of ANO3 in this process.
Research suggests that ANO3 protein may have additional roles beyond its function as a calcium-activated chloride channel. Some studies have proposed its involvement in pain sensation and regulation of neuronal excitability in the brain.
Future research on ANO3 protein may involve studying its precise role in neuronal excitability, synaptic transmission, and movement disorders. Investigating additional cellular and physiological processes influenced by ANO3 and exploring potential therapeutic interventions are also important areas of future research.
Besides the association with autosomal dominant dystonia, ANO3 mutations have also been linked to essential tremor, a common movement disorder characterized by rhythmic shaking of hands, head, or other body parts. However, the exact mechanisms by which ANO3 dysfunction contributes to these conditions are still being investigated.
As of now, ANO3 protein has not been widely explored as a biomarker for specific diseases. However, ongoing research may reveal its potential as a diagnostic or prognostic indicator for movement disorders or other conditions associated with ANO3 dysfunction.
Yes, ANO3 protein is believed to interact with various proteins to regulate its activity or modulate signaling pathways. For example, ANO3 has been found to interact with proteins involved in calcium signaling and synaptic transmission, including SNAP25 and SHANK proteins.
While there is limited knowledge about specific modulators of ANO3 activity, it is known that phosphorylation can regulate its function. Protein kinase A (PKA) has been shown to phosphorylate ANO3, which may modulate its calcium sensitivity and activity.
Currently, there are no specific small molecules known to modulate ANO3 activity. Discovering compounds that can selectively modulate ANO3 channels may be a focus of future research to explore therapeutic options for ANO3-related disorders.
ANO3 channels are activated by increases in intracellular calcium levels. When calcium ions bind to specific sites on ANO3, it induces conformational changes that open the channel, allowing the flow of chloride ions across the cell membrane.
Currently, there are no specific drugs or therapies targeting ANO3. However, as research on ANO3 continues, it may provide insights into potential therapeutic strategies for movement disorders and other conditions associated with ANO3 dysfunction.
There is evidence suggesting that ANO3 protein plays a role in neuronal development. Studies have shown its expression during embryonic brain development, particularly in regions involved in neurogenesis and neuronal migration. However, further research is needed to understand the specific contributions of ANO3 in neuronal development.
Several mechanisms regulate ANO3 protein activity. Calcium signaling pathways, such as calmodulin binding or activation of protein kinases, can modulate ANO3 function. Post-translational modifications like phosphorylation and palmitoylation have also been suggested to impact ANO3 protein regulation.
Customer Reviews (3)
Write a reviewIts reliability and versatility make it an essential tool for investigating ANO3 protein's expression, function, and structural characteristics.
By visualizing the structural features, interactions, and conformational changes of ANO3, researchers gain valuable insights into its function and potential for therapeutic interventions.
ANO3 protein is highly recommended for researchers due to its excellent performance in WB experiments and its utility in protein electron microscopy structure analysis.
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