anterior pharynx defective 1 homolog B (C. elegans)
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein.
APH1B involved in several pathways and played different roles in them. We selected most pathways APH1B participated on our site, such as Notch signaling pathway, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APH1B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
APH1B has several biochemical functions, for example, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APH1B itself. We selected most functions APH1B had, and list some proteins which have the same functions with APH1B. You can find most of the proteins on our site.
Function endopeptidase activity
Related Protein NCSTN; MMP9; PSMB4; RHBDD1; SENP5; PSMB5; PSMA6A; ECE1; APH1C; TPP2
APH1B Related Articles
Fazzari, P; Snellinx, A; et al. Cell autonomous regulation of hippocampal excitatory circuitry via Aph1b-gamma-secretase/Neuregulin 1 signalling. ELIFE 3:-(2014).
Acx, H; Chavez-Gutierrez, L; et al. Signature Amyloid beta Profiles Are Produced by Different gamma-Secretase Complexes. JOURNAL OF BIOLOGICAL CHEMISTRY 289:4346-4355(2014).