aph1b
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  • Official Full Name
  • anterior pharynx defective 1 homolog B (C. elegans)
  • Background
  • This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein.
  • Synonyms
  • APH1B; anterior pharynx defective 1 homolog B (C. elegans); gamma-secretase subunit APH-1B; APH 1B; DKFZp564D0372; PSFL; Anterior pharynx defective 1 homolog B; Anterior pharynx defective 1B like; Anterior pharynx defective 1b short splicing variant; Aph 1beta; APH-1b; Aph-1beta; Aph1 beta; APH1B_HUMAN; Aph1beta; Gamma secretase subunit APH 1B; Gamma secretase subunit APH1B; Gamma secretase sununit; Presenilin stabilisation factor like; Presenilin-stabilization factor-like; PRO 1328; PRO1328; TAAV 688; TAAV688
Cat.#:APH1B-1768MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse APH1B Protein
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Cat.#:APH1B-10467ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish APH1B
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Involved Pathway

APH1B involved in several pathways and played different roles in them. We selected most pathways APH1B participated on our site, such as Notch signaling pathway, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APH1B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Notch signaling pathway
DTX2; NCOR2; NOTCH1; LNX1; RBPJL; APH1C; MIB1; APH1B; LFNG; DLC
Alzheimers disease
MAPT; NDUFS2; PPP3CB; PSEN2; COX6A1; PSENEN; NDUFB4; GRIN2A; LPL; ADAM17

Protein Function

APH1B has several biochemical functions, for example, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APH1B itself. We selected most functions APH1B had, and list some proteins which have the same functions with APH1B. You can find most of the proteins on our site.
Function
Related Protein
Function endopeptidase activity
Related Protein NCSTN; MMP9; PSMB4; RHBDD1; SENP5; PSMB5; PSMA6A; ECE1; APH1C; TPP2

APH1B Related Articles

Fazzari, P; Snellinx, A; et al. Cell autonomous regulation of hippocampal excitatory circuitry via Aph1b-gamma-secretase/Neuregulin 1 signalling. ELIFE 3:-(2014).
Acx, H; Chavez-Gutierrez, L; et al. Signature Amyloid beta Profiles Are Produced by Different gamma-Secretase Complexes. JOURNAL OF BIOLOGICAL CHEMISTRY 289:4346-4355(2014).