APH1B
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Official Full Name
anterior pharynx defective 1 homolog B (C. elegans)
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Overview
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. -
Synonyms
APH1B; anterior pharynx defective 1 homolog B (C. elegans); gamma-secretase subunit APH-1B; APH 1B; DKFZp564D0372; PSFL; Anterior pharynx defective 1 homolog B; Anterior pharynx defective 1B like; Anterior pharynx defective 1b short splicing variant; Aph 1beta; APH-1b; Aph-1beta; Aph1 beta; APH1B_HUMAN; Aph1beta; Gamma secretase subunit APH 1B; Gamma secretase subunit APH1B; Gamma secretase sununit; Presenilin stabilisation factor like; Presenilin-stabilization factor-like; PRO 1328; PRO1328; TAAV 688; TAAV688;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Danio rerio (Zebrafish) (Brachydanio rerio)
- Homo sapiens (Human)
- Mouse
- Mus musculus (Mouse)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Zebrafish
- E.coli expression system
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Mouse | APH1B-1768M | Recombinant Mouse APH1B Protein | Mammalian Cell | His |
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| Mouse | APH1B-618M | Recombinant Mouse APH1B Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | APH1B-618M-B | Recombinant Mouse APH1B Protein Pre-coupled Magnetic Beads | HEK293 |
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| Danio rerio (Zebrafish) (Brachydanio rerio) | RFL5740DF | Recombinant Full Length Danio Rerio Gamma-Secretase Subunit Aph-1B(Aph1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-258) |
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| Homo sapiens (Human) | RFL24752HF | Recombinant Full Length Human Gamma-Secretase Subunit Aph-1B(Aph1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-257) |
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| Mus musculus (Mouse) | RFL8174MF | Recombinant Full Length Mouse Gamma-Secretase Subunit Aph-1B(Aph1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-257) |
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| Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) | RFL26621PF | Recombinant Full Length Pongo Abelii Gamma-Secretase Subunit Aph-1B(Aph1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-257) |
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| Zebrafish | APH1B-10467Z | Recombinant Zebrafish APH1B | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- APH1B Related Articles
- APH1B Related Research Area
- APH1B Related Signal Pathway
APH1B involved in several pathways and played different roles in them. We selected most pathways APH1B participated on our site, such as Notch signaling pathway, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APH1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | DTX1;JAG2B;NOTCH3;HER15.1;DTX4;DVL3A;MFAP2;TLE3A;RFNG |
| Alzheimers disease | MME;PSEN2;NDUFA6;CALM2;ATP2A3;CALM4;PPP3CB;COX7A1;NDUFB2 |
APH1B has several biochemical functions, for example, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APH1B itself. We selected most functions APH1B had, and list some proteins which have the same functions with APH1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | PSMB7;KLK1B1;PSMB8;MMP1;PSMA6B;NCSTN;ACE2;PSMB8F;PSMA1 |
APH1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APH1B here. Most of them are supplied by our site. Hope this information will be useful for your research of APH1B.
- Q&As
- Reviews
Q&As (10)
Ask a questionAPH1B s are expressed at different levels in different cell types, depending on the characteristics and functional requirements of the cell.
The potential application of APH1B in disease diagnosis is currently under investigation and requires further scientific validation.
APH1B can be expressed and purified in cells through genetic engineering technology.
The APH1B can be used to screen potential drug molecules for drugs that can regulate the function of the gamma-secretase complex.
When APH1B s are used in experiments, standard biosafety practices should be followed and experimental conditions strictly controlled.
There are currently no APH1B recombinant drugs on the market, but researchers are working hard to develop related drugs.
As a biochemical agent, APH1B is generally not applied directly to patients, so there are no side effects.
According to scientific research, APH1B is associated with neurodegenerative diseases such as Alzheimer's disease.
APH1B is a component of the gamma-secretase complex, which is involved in cell signaling pathway regulation and protein processing.
According to studies, APH1B s interact with other gamma-secretase complex components such as PSEN1 and PSEN2.
Customer Reviews (4)
Write a reviewIn a variety of application scenarios, the stability of APH1B is very good, regardless of the concentration, temperature, pH value changes, it can maintain stable performance.
Good repeatability, predictable results.
The resolution of APH1B in Western blot is very high, which can clearly distinguish different sizes of proteins, indicating that it has excellent separation and identification ability.
We are satisfied with the performance and quality of their products and will continue to buy them.
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