ASAP2
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Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
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Overview
PAG3 (paxillin-associated protein with ADP-ribosylation factor [ARF] GTPase-activating protein [GAP] activity, number 3) is a member of the ARF GAP family of proteins that associates with the cytoskeleton, plays an important role in mediating actin cytosk -
Synonyms
ASAP2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; DDEF2, development and differentiation enhancing factor 2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; centaurin; beta 3; CENTB3; KIAA0400; PAP; SHAG1; centaurin,;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ASAP2-9911H | Recombinant Human ASAP2, His-tagged | E.coli | His | 1-357a.a. | |
Human | ASAP2-3618H | Recombinant Human ASAP2, His-tagged | E.Coli or Yeast | His | 961 | |
Human | ASAP2-2436H | Recombinant Human ASAP2 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ASAP2-8667HCL | Recombinant Human ASAP2 293 Cell Lysate | HEK293 | N/A | ||
Human | ASAP2-2445HF | Recombinant Full Length Human ASAP2 Protein, GST-tagged | In Vitro Cell Free System | GST | 1006 amino acids |
- Involved Pathway
- Protein Function
- Interacting Protein
ASAP2 involved in several pathways and played different roles in them. We selected most pathways ASAP2 participated on our site, such as Endocytosis, Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Endocytosis | DNM3;KITB;RAB11B;HSC70;ADRB2B;HSPA1B;VPS35;ARAP2;ARRB2A |
Fc gamma R-mediated phagocytosis | RAF1;INPPL1;PTPRC;SPHK2;ARF6;WASF1;PIK3R1;PRKCB;AMPH |
ASAP2 has several biochemical functions, for example, GTPase activator activity, enzyme activator activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASAP2 itself. We selected most functions ASAP2 had, and list some proteins which have the same functions with ASAP2. You can find most of the proteins on our site.
Function | Related Protein |
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GTPase activator activity | GAPVD1;CDC42EP1B;TBC1D9;TBC1D1;RAP1GAP;ACAP3B;ERRFI1;ARAP1;RGS5 |
enzyme activator activity | CFLAR;ARL1;PRKCE;PPP1R12B;ALDH1A2;DNMT3L;MMP15;PSAP;PSAPL1 |
metal ion binding | ZFP36L1B;LMX1BA;OAS3;OSR1;COPS5;COLEC12;OVOL3;EME1;PRR3 |
protein binding | LRRC8C;CCT4;C12orf43;ARL16;KAT5;SORBS2;ARPC4;MTRR;CLDN2 |
ASAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASAP2.
GRB2; apc; PLCG1; q5jpt6_human; UBC; VILL; FYN; SRC; NCK1; PIK3R1
- Q&As
- Reviews
Q&As (8)
Ask a questionASAP2 is found in the cytoplasm, associated with cellular membranes, particularly the Golgi apparatus and endosomes.
Yes, ASAP2 can undergo phosphorylation and ubiquitination, which may influence its stability, activity, and protein-protein interactions.
Yes, ASAP2 can interact with various proteins involved in membrane trafficking, including clathrin, AP1, AP3, and many others.
ASAP2 has been implicated in cancer metastasis due to its ability to promote cell migration and invasion through its effect on the actin cytoskeleton.
ASAP2 promotes the hydrolysis of GTP bound to Arf1, leading to the inactivation of Arf1 and subsequent modulation of vesicle budding, cargo sorting, and membrane remodeling.
ASAP2 contains an SH3 domain, an ANK repeat domain, and a PH (pleckstrin homology) domain.
Genetic variations in ASAP2 have been identified in some studies, and they may be linked to certain diseases or phenotypes, although further research is needed to establish concrete associations.
Yes, ASAP2 has been suggested to modulate cell adhesion and migration by regulating actin cytoskeleton dynamics through its interaction with Rho family GTPases.
Customer Reviews (3)
Write a reviewThe ASAP2 protein exhibits outstanding performance in enzyme-linked immunosorbent assays (ELISA).
The protein's reliability and reproducibility in WB ensure accurate analysis of target proteins, while its suitability for electron microscopy structure analysis enables detailed examination of molecular structures.
The versatility and efficacy of ASAP2 in these applications make it an invaluable tool for researchers.
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