APLP2
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Official Full Name
amyloid beta (A4) precursor-like protein 2
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Overview
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimers disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
APLP2; amyloid beta (A4) precursor-like protein 2; amyloid-like protein 2; amyloid beta (A4) precursor like protein 2; Amyloid like protein 2; amyloid precursor protein homolog HSD2; Amyloid protein homolog; APLP-2; APLP2_HUMAN; APPH; APPL2; CDEBP; CDEI box binding protein; CDEI box-binding protein; amyloid precursor protein homolog HSD-2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | APLP2-688H | Recombinant Human APLP2 protein, GST-tagged | Wheat Germ | GST |
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| Human | APLP2-9746H | Recombinant Human APLP2, GST-tagged | E.coli | GST | 33-360a.a. | |
| Human | APLP2-92HCL | Recombinant Human APLP2 cell lysate | N/A |
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| Human | APLP2-2283H | Recombinant Human APLP2 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | APLP2-395H | Recombinant Human APLP2 Protein, His-tagged | E.coli | His | Met1~Gly210 | |
| Human | APLP2-3275H | Recombinant Human APLP2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | APLP2-1110HF | Recombinant Full Length Human APLP2 Protein, GST-tagged | In Vitro Cell Free System | GST | 522 amino acids |
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| Human | APLP2-1938H | Recombinant Human APLP2 protein, His-tagged | HEK293 | His | Gly 32 - Ser 692 |
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| Mouse | APLP2-1777M | Recombinant Mouse APLP2 Protein | Mammalian Cell | His |
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| Mouse | APLP2-624M | Recombinant Mouse APLP2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | APLP2-1939M | Recombinant Mouse APLP2 protein, His-tagged | HEK293 | His | Gly 32 - Ser 636 |
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| Mouse | APLP2-624M-B | Recombinant Mouse APLP2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Aplp2-630M | Recombinant Mouse Aplp2 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK |
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| Rat | Aplp2-3444R | Recombinant Rat Aplp2, His-tagged | E.Coli or Yeast | His | 765 |
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| Mus musculus (Mouse) | RFL-25650MF | Recombinant Full Length Mouse Amyloid-Like Protein 2(Aplp2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (32-707) |
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| Rattus norvegicus (Rat) | RFL-27372RF | Recombinant Full Length Rat Amyloid-Like Protein 2(Aplp2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (32-765) |
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| Zebrafish | APLP2-6619Z | Recombinant Zebrafish APLP2 | Mammalian Cell | His |
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| Chicken | APLP2-1462C | Recombinant Chicken APLP2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- APLP2 Related Articles
APLP2 involved in several pathways and played different roles in them. We selected most pathways APLP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APLP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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APLP2 has several biochemical functions, for example, DNA binding, heparin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APLP2 itself. We selected most functions APLP2 had, and list some proteins which have the same functions with APLP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | CERS4A;ZNF34;LHFP;CENPA;IRX5B;PTF1A;MYPOP;VED;LIG4 |
| heparin binding | LPA;FGFR2;PRG2;CLEC3B;THBS4;ABP1;CXCL13;FN1;MDK |
| identical protein binding | SIAH1A;PTPRG;MNS1;ACTG1;POU3F2;DNM1;GOT2A;CEACAM16;CHMP4A |
| protein binding | ALAS1;OAZ3;MED11;ANKMY2;ETV1;NIPBL;ARMCX1;RPL12;WIPF1 |
| serine-type endopeptidase inhibitor activity | SERPINA6;SPINK13;OVAL;SPOCK1;SPINLW1;FURIN;PAPLNB;SERPIND1;WFDC13 |
| transition metal ion binding | APLP2;APPB;HRSP12;APP;APPA;APLP1 |
APLP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APLP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APLP2.
JUN; APP; APLP1; DEDD; MED12; ETS1; JUNB; NFKB1; Slc5a7
- Q&As
- Reviews
Q&As (20)
Ask a questionClinical trials of APLP2 are still in the early stages, and more experimental validation and clinical trials are needed.
The synthesis of APLP2 can be carried out in the cell expression system through genetic engineering technology.
The recombinant APLP2 protein may be used clinically to treat clinical problems associated with neurodegenerative diseases.
APLP2 may play an important role in synaptic formation and plasticity regulation of neurons.
APLP2 is a transmembrane protein that is mainly involved in the regulation of nerve cell growth and synaptic development.
APLP2 may be involved in cell signaling, but the specific mechanism needs further study.
Recombinant APLP2 may be involved in the regulation of synaptic plasticity, but the specific mechanism needs further study.
Some variants and mutations of APLP2 s have been found, but their biological functions require more research.
The recombinant APLP2 protein may play a role in some neurodegenerative diseases, such as Alzheimer's disease.
You can search relevant academic databases or literature search platforms for research on APLP2 .
The preparation of high purity APLP2 requires strict purification steps such as affinity chromatography and ion exchange chromatography.
At present, the specific application of APLP2 in the diagnosis of neurodegenerative diseases has not been reported.
The recombinant APLP2 protein may play an important role in the pathogenesis of neurodegenerative diseases and can therefore be used as a potential drug target.
There may be some structural and functional differences between APLP2 and other related proteins, which need further study.
APLP2 has been widely used in the fields of neuroscience, cell biology and molecular biology.
APLP2 may have a certain relationship with the occurrence and development of Alzheimer's disease, but the specific mechanism is not fully understood.
APLP2 may promote neuron growth, but the detailed mechanism still needs to be further explored.
APLP2 may play a role in the treatment of neurodegenerative diseases, but the specific treatment strategy is still to be studied.
The stability of APLP2 is affected by various factors, such as temperature, pH, etc., and it needs reasonable preservation conditions.
There have been no reported side effects from the use of APLP2, but further studies are needed before use.
Customer Reviews (4)
Write a reviewHigh purity, reduce the interference of impurities in the experiment.
Production quality is very good, can be seen in the production of strict control of quality.
The background in Western blot is very clean, indicating that the antibody has a weak ability to bind to non-target proteins, reducing the interference of non-specific signals.
Stability of APLP2 has been verified in many experiments, and it can maintain stable performance no matter how the conditions change.
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