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CNKSR1

Official Full Name

connector enhancer of kinase suppressor of Ras 1
Overview

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target.It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.
Synonyms

CNKSR1; connector enhancer of kinase suppressor of Ras 1; CNK; CNK1; KSR; CNK homolog protein 1; Connector enhancer of KSR like; Connector enhancer of KSR1; hCNK1; connector enhancer of KSR 1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CNKSR1-1562H	Recombinant Human CNKSR1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CNKSR1-373HCL	Recombinant Human CNKSR1 cell lysate		N/A		Inquiry
Human	CNKSR1-1926HF	Recombinant Full Length Human CNKSR1 Protein, GST-tagged	In Vitro Cell Free System	GST	720 amino acids	Inquiry
Zebrafish	CNKSR1-11686Z	Recombinant Zebrafish CNKSR1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CNKSR1 Related Articles

CNKSR1 involved in several pathways and played different roles in them. We selected most pathways CNKSR1 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNKSR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ARMS-mediated activation	CSF2;RASGEF1A;SPNA2;DUSP6;SPNA1;EGF;JAK1;FGF10B;DUSP10
Axon guidance	PEA15;DUSP9;JAK2;KALRNB;DCX;LOC608458;ARHGEF28;FRS2A;CSF2RB
Cytokine Signaling in Immune system	OASL;DUSP10;IRAK3;FRS2A;EDAR;GBP2;IFI35;CSF2RB;FCGR1B
DAP12 interactions	TREM1;MARK3;PTPRA;WDR83;SPRED2;CD300LB;RASGEF1A;DUSP2;DUSP6
DAP12 signaling	SPTBN1;PHB;FGFR1B;SPTB;PRKAR1AA;FRS2A;DUSP7;SPTA1;GRAP2B
Developmental Biology	LGI4;RHOC;LIN28A;PHB;CNKSR1;SREBF2;GDNF;CLTB;ITSN1
Downstream signal transduction	RASGRP4;KBTBD7;DUSP9;SPTBN2;PEA15A;SPRED1;AGO1;FGF18B;SPTA1
Downstream signaling of activated FGFR1	SPTA1;WDR83;PAQR3B;PEA15A;PTPRA;SPRED3;RASGEF1A;IL17RD;DAB2IPB

CNKSR1 has several biochemical functions, for example, protein binding, protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by CNKSR1 itself. We selected most functions CNKSR1 had, and list some proteins which have the same functions with CNKSR1. You can find most of the proteins on our site.

Function	Related Protein
protein binding	RNF4;TTC35;KLHL35;RNF24;KLRC1;NFKBIL2;KIAA1967;PPP1R8;SUMO2
protein binding, bridging	CSTA;PPP4R2;FLRT1;FGA;FSCN2A;FLRT3;FSCN1;TRIM5;FSCN3

CNKSR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNKSR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNKSR1.

CYTH3; PIN1; CYTH4; RHOA; RHOC; RHOH; Raf1; SMAD4; ZDHHC17

Soundararajan, R; Ziera, T; et al. Scaffold Protein Connector Enhancer of Kinase Suppressor of Ras Isoform 3 (CNK3) Coordinates Assembly of a Multiprotein Epithelial Sodium Channel (ENaC)-regulatory Complex. JOURNAL OF BIOLOGICAL CHEMISTRY 287:33014-33025(2012).

Farhan, H; Wendeler, MW; et al. MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening. JOURNAL OF CELL BIOLOGY 189:997-1011(2010).