exoc1
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  • Official Full Name
  • exocyst complex component 1
  • Background
  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described.
  • Synonyms
  • EXOC1; exocyst complex component 1; SEC3 like 1 (S. cerevisiae) , SEC3L1; BM 102; FLJ10893; SEC3; Sec3p; BM-012; EXOC1_HUMAN; Exocyst complex component Sec3; SEC3 like 1; SEC3L1; SEC3-like 1; BM-102
Cat.#:EXOC1-12585HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EXOC1, GST-tagged
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Cat.#:EXOC1-1515RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EXOC1 Protein, His-tagged
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Cat.#:EXOC1-10000ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EXOC1
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Involved Pathway

EXOC1 involved in several pathways and played different roles in them. We selected most pathways EXOC1 participated on our site, such as Arf6 trafficking events, Assembly of the primary cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOC1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arf6 trafficking events
CLTC; DNM2; PTBP3; EXOC6; CHRM2; EXOC3; CTNND1; EXOC5; CPE; SCAMP2
Assembly of the primary cilium
WDR35; CCT5; HDAC6; KIF3B; CDK5RAP2; TTC30A1; NDE1; MARK4; CSNK1E; CNGA2
Cargo trafficking to the periciliary membrane
SSTR3; UNC119B; RHOL; BBS2; BBS9; CNGA2; CCT8; SETD6; BBS10; BBS4
Insulin Pathway
EXOC5; GRB10; EXOC1; GRB14; EXOC3; DOK1; EXOC6
Insulin processing
CPE; PCSK2; EXOC6; CPN1; EXOC3; KIF5B; EXOC5; EXOC8; EXOC1; SLC30A8
Membrane Trafficking
CLINT1; TMED2; EXOC6; RALAB; NAPAA; TBC1D8B; EXOC1; CNIH3; LMAN2L; SNF8
Metabolism of proteins
IGFBP6A; SPON1A; ADAMTS15; MUCL1; PROCA; ZDHHC2; B3GALTL; UBA2; ADD1; B3GNT6
Organelle biogenesis and maintenance
NPHP4; MTRF1L; TMEM216; ATAT1; DYF-1; POLRMT; MKS1; MRPL3; IFT80; C11orf60

Protein Function

EXOC1 has several biochemical functions, for example, GTP-Rho binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOC1 itself. We selected most functions EXOC1 had, and list some proteins which have the same functions with EXOC1. You can find most of the proteins on our site.
Function
Related Protein
Function GTP-Rho binding
Related Protein ROCK2A; RTKN; EXOC1; TNFAIP1; WHAMM; CDC42EP1; PKN1; KCTD13; ROCK1; ROCK2B
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein RS1; SNX20; RPH3A; MARK1; FAM21C; TULP1; TWF1; ADAP2; FAM123A; Apba1
Function protein binding
Related Protein ZBTB4; RSG1; ASB2; SLIT2; CETN2; LANCL1; RASSF1; CAML; SCGB2A2; HIST2H3C2

Interacting Protein

EXOC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOC1.
WASH1; MYC; Kiaa0226; Atg14; SH3BP5; TRIO; SNAPIN; DST; GOLGA4; SPTAN1; COLEC12; ilvD; EXOC4; NUF2; TRIM9; CEP295; CCSER2; KIAA1551; DISC1

EXOC1 Related Articles

Carone, C; Genedani, S; et al. In Vitro Effects of Cocaine on Tunneling Nanotube Formation and Extracellular Vesicle Release in Glioblastoma Cell Cultures. JOURNAL OF MOLECULAR NEUROSCIENCE 55:42-50(2015).
Lee, MS; Lin, YS; et al. Modulation of alternative splicing by expression of small nuclear ribonucleoprotein polypeptide N. FEBS JOURNAL 281:5194-5207(2014).