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EXOC1

Official Full Name

exocyst complex component 1
Overview

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Synonyms

EXOC1; exocyst complex component 1; SEC3 like 1 (S. cerevisiae) , SEC3L1; BM 102; FLJ10893; SEC3; Sec3p; BM-012; EXOC1_HUMAN; Exocyst complex component Sec3; SEC3 like 1; SEC3L1; SEC3-like 1; BM-102;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EXOC1-12585H	Recombinant Human EXOC1, GST-tagged	E.coli	GST	C-term-350a.a.	$319 / 25ug
Rhesus Macaque	EXOC1-1515R	Recombinant Rhesus monkey EXOC1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	EXOC1-1340R-B	Recombinant Rhesus Macaque EXOC1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	EXOC1-1340R	Recombinant Rhesus Macaque EXOC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	EXOC1-10000Z	Recombinant Zebrafish EXOC1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
EXOC1 Related Articles

EXOC1 involved in several pathways and played different roles in them. We selected most pathways EXOC1 participated on our site, such as Arf6 trafficking events, Assembly of the primary cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Arf6 trafficking events	EXOC6;EXOC1;SPAG9;DNM2;SCAMP2;CTNND1;ADRB2;EDNRB;JUP
Assembly of the primary cilium	DYNLL2A;TNPO1;MAPRE1B;ODF2;PROL1;UNC119.1;CEP57;CEP152;CLUAP1
Cargo trafficking to the periciliary membrane	RP2;CCT8;CCT5;EXOC8;CNGA2;PKD1;BBS9;RHOL;ARF4
Insulin Pathway	EXOC6;DOK1;GRB14;EXOC1;EXOC5;GRB10;EXOC3
Insulin processing	PCSK2;EXOC8;PCSK1;EXOC1;SLC30A5;SLC30A6;EXOC5;SLC30A8;CPE
Membrane Trafficking	SH3D19;SNX9;TRAPPC5;ANKRD28;TRAPPC6B;GJA5;BLOC1S1;PPP6R1;COPB1
Metabolism of proteins	HDGF;MUC12;CMA1;EXOC6;IGFBP2B;MUCL1;ADAMTS1;MUC15;CHCHD4
Organelle biogenesis and maintenance	IFT52;MRPS34;IFT172;ARL3;CCDC123;RABL5;MRPL48;KIFAP3B;KIF17

EXOC1 has several biochemical functions, for example, GTP-Rho binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOC1 itself. We selected most functions EXOC1 had, and list some proteins which have the same functions with EXOC1. You can find most of the proteins on our site.

Function	Related Protein
GTP-Rho binding	ROCK2B;CDC42EP2;EXOC1;TRIOBP;RTKN;ROCK1;RTKN2B;ROCK2A;CDC42EP5
phosphatidylinositol-4,5-bisphosphate binding	Apba1;SYT1;ALOX15;STXBP6L;SNX18;FRMPD4;FCHO2;RAG2;KCNJ1
protein binding	AP2M1;STAU1;SMG9;KIF6;KIF20B;ZC3HAV1;FGF12;C9orf142;FAM109A

EXOC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOC1.

WASH1; MYC; Kiaa0226; Atg14; SH3BP5; TRIO; SNAPIN; DST; GOLGA4; SPTAN1; COLEC12; ilvD; EXOC4; NUF2; TRIM9; CEP295; CCSER2; KIAA1551; DISC1

Carone, C; Genedani, S; et al. In Vitro Effects of Cocaine on Tunneling Nanotube Formation and Extracellular Vesicle Release in Glioblastoma Cell Cultures. JOURNAL OF MOLECULAR NEUROSCIENCE 55:42-50(2015).

Lee, MS; Lin, YS; et al. Modulation of alternative splicing by expression of small nuclear ribonucleoprotein polypeptide N. FEBS JOURNAL 281:5194-5207(2014).