FMO3
-
Official Full Name
flavin containing monooxygenase 3
-
Overview
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide. -
Synonyms
FMO3; flavin containing monooxygenase 3; dimethylaniline monooxygenase [N-oxide-forming] 3; Dimethylaniline monooxygenase [N oxide forming] 3; Dimethylaniline monooxygenase 3; Dimethylaniline oxidase 3; dJ127D3.1; FMO 3; FMO form 2; FMO II; FMO3_HUMAN; FMOII; Hepatic flavin containing monooxygenase 3; Hepatic flavin-containing monooxygenase 3; MGC34400; hepatic flavin-containing monooxygenase-3; TMAU;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- FMO3 Related Articles
FMO3 involved in several pathways and played different roles in them. We selected most pathways FMO3 participated on our site, such as Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Drug metabolism - cytochrome P | AOX1;GSTA5;UGT5G1;AOX2P;UGT1AB;UGT1A6B;GSTM5;GSTA;UGT1A6 |
FMO3 has several biochemical functions, for example, N,N-dimethylaniline monooxygenase activity, NADP binding, flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMO3 itself. We selected most functions FMO3 had, and list some proteins which have the same functions with FMO3. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
N,N-dimethylaniline monooxygenase activity | FMO3;FMO1;FMO5;FMO2 |
NADP binding | DPYD;NNT;ASPDH;POR;G6PDX;GAPDH;NDOR1;NOS1;FMO2 |
flavin adenine dinucleotide binding | DUS3L;SQLEA;XDH;CYB5R3;KDM1B;DUS4L;FMO5;NOX5;FOXRED2 |
trimethylamine monooxygenase activity |
FMO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FMO3.
- Q&As
- Reviews
Q&As (6)
Ask a questionThe activity of FMO3 is affected by a variety of factors, including genetic factors, dietary factors, environmental factors, etc.
It plays an important role in cancer, and it can affect the occurrence and progression of cancer by regulating the metabolism of some carcinogens.
FMO3 is also associated with neurological diseases, and studies have shown that FMO3 can regulate the metabolism of neurotransmitters and affect the function of the nervous system.
This protein is also associated with cardiovascular disease, and studies have shown that FMO3 can regulate cholesterol metabolism and affect the development of cardiovascular disease.
Yes, there are genetic variants in FMO3 that can affect FMO3 activity and expression levels.
FMO3 activity can be regulated by changing dietary Xi, increasing exercise, and regulating antioxidants in the diet.
Customer Reviews (3)
Write a reviewIt is easy to operate, and it does not take too long to learn Xi to operate, saving time.
The FMO3 they produce is of high purity and the experimental results are accurate.
It is suitable for novices and has low technical and environmental requirements.
Ask a Question for All FMO3 Products
Required fields are marked with *
My Review for All FMO3 Products
Required fields are marked with *