gipc1
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  • Official Full Name
  • GIPC PDZ domain containing family, member 1
  • Background
  • GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008;(PubMed 18775991)).
  • Synonyms
  • GIPC1; GIPC PDZ domain containing family, member 1; C19orf3, chromosome 19 open reading frame 3 , regulator of G protein signalling 19 interacting protein 1 , RGS19IP1; PDZ domain-containing protein GIPC1; GIPC; GLUT1CBP; Hs.6454; NIP; SEMCAP; SYNECTIN; TIP 2; C19ORF3; Chromosome 19 open reading frame 3; GLUT1 C terminal binding protein; IGF 1 receptor interacting protein 1; IIP 1; IIP1; Regulator of G protein signalling 19 interacting protein 1; RGS19 interacting protein 1; RGS19IP1; SYNECTIIN; Tax interaction protein 2; RGS19-interacting protein 1; RGS-GAIP-interacting protein; GLUT1 C-terminal binding protein; GAIP C-terminus-interacting protein; IGF-1 receptor interacting protein 1; regulator of G-protein signalling 19 interacting protein 1; IIP-1; TIP-2
Cat.#:GIPC1-4913HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GIPC1 Protein, GST-tagged
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Cat.#:GIPC1-2897HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GIPC1, T7-tagged
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Cat.#:GIPC1-29065THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GIPC1, His-tagged
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Cat.#:GIPC1-6363MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GIPC1 Protein
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Cat.#:GIPC1-2541RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GIPC1 Protein
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Cat.#:GIPC1-1216ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GIPC1
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Cat.#:GIPC1-5928HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GIPC1 293 Cell Lysate
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Involved Pathway

GIPC1 involved in several pathways and played different roles in them. We selected most pathways GIPC1 participated on our site, such as Neurotrophic factor-mediated Trk receptor signaling, Syndecan-4-mediated signaling events, TGF-beta Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GIPC1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neurotrophic factor-mediated Trk receptor signaling
DYNLT1; RGS19; FAIM; RIT1; GIPC1; MCF2L; RIT2
Syndecan-4-mediated signaling events
MDK; GIPC1; ADAM12
TGF-beta Receptor Signaling Pathway
CITED1; CTCF; TRAP1; ZEB2A; STAMBPL1; RUNX2A; SNIP1; ACVRL1; HOXD9A; TGFBR3

Protein Function

GIPC1 has several biochemical functions, for example, PDZ domain binding, actin binding, myosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GIPC1 itself. We selected most functions GIPC1 had, and list some proteins which have the same functions with GIPC1. You can find most of the proteins on our site.
Function
Related Protein
Function PDZ domain binding
Related Protein PARK2; LIN7C; LIN7B; EXOC4; SLC26A6; PLEKHA1; LPAR2; CIT; PSEN1; DOCK4
Function actin binding
Related Protein FSCN1; DAG1; FXYD5; CAPG; FGD4; MYO5C; DAAM1; GSN; TPM1; MYO1C
Function myosin binding
Related Protein TRIM32; VAMP2; KIRREL; ARFGEF2; CALM; STX4A; NPHS1; MYBPC3; ACTA1; ARFGEF1
Function protein binding
Related Protein STATH; SH2D3A; CELSR1; ETV7; ZNF559; STOML1; LACTB2; RBM15B; SPARC; FAM20C
Function protein homodimerization activity
Related Protein HM13; ASNS; STUB1; ENG; AMICA1; SDCBP2; CBX5; MUC13; PTPRO; ENPP1
Function receptor binding
Related Protein EDA; TAC3; ITGA1; ANGPTL1; PVRL1B; TNFSF9; PEX14; ADIPOQ; TDGF1; FGF1B

Interacting Protein

GIPC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GIPC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GIPC1.
E6; TYRP1; TGFBR3; TPBG; 42734339; MYO1C; BCR; PRKCA; SDC4; MCM7; COPB2; SSR4

GIPC1 Related Articles

Sensoy, O; Weinstein, H; et al. A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1848:976-983(2015).
Solomon, O; Bazak, L; et al. Characterizing of functional human coding RNA editing from evolutionary, structural, and dynamic perspectives. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 82:3117-3131(2014).