SHMT2
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Official Full Name
serine hydroxymethyltransferase 2 (mitochondrial)
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Overview
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. -
Synonyms
SHMT2; serine hydroxymethyltransferase 2 (mitochondrial); SHMT; serine hydroxymethyltransferase, mitochondrial; GLYA; Glycine hydroxymethyltransferase; Serine hydroxymethyltransferase mitochondrial; Serine methylase; SHMT 2; GLY A+; serine aldolase; threonine aldolase; serine hydroxymethylase; glycine auxotroph A, human complement for hamster;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- GST
- His
- N/A
- N
- No tag
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | SHMT2-927H | Recombinant Human SHMT2 Protein, His-tagged | E.coli | His | ||
Human | SHMT2-31356TH | Recombinant Human SHMT2, His-tagged | E.coli | His | ||
Human | SHMT2-2662H | Recombinant Human SHMT2, GST-tagged | E.coli | GST | C-term-300aa | |
Human | SHMT2-1853HCL | Recombinant Human SHMT2 293 Cell Lysate | HEK293 | N/A | ||
Human | SHMT2-0225H | Recombinant Human SHMT2 Protein (S29-H504), His tagged | E.coli | His | S29-H504 | |
Human | SHMT2-6286H | Recombinant Human SHMT2 Protein (Asn30-His504), N-His tagged | E.coli | N-His | Asn30-His504 | |
Human | SHMT2-0224H | Recombinant Human SHMT2 Protein (S29-H504), Tag Free | E.coli | No tag | S29-H504 | |
Zebrafish | SHMT2-6698Z | Recombinant Zebrafish SHMT2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- SHMT2 Related Articles
SHMT2 involved in several pathways and played different roles in them. We selected most pathways SHMT2 participated on our site, such as Glycine, serine and threonine metabolism, Cyanoamino acid metabolism, Glyoxylate and dicarboxylate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHMT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycine, serine and threonine metabolism | SDS;PHGDH;DLDH;ALDH7A1;SRR;CBSB;GCSHB;AGXTA;ALAS2 |
Cyanoamino acid metabolism | GGT5A;SHMT2;GGT7;GGT1;GGT6;SHMT1;GGT5;GGT1A;GBA3 |
Glyoxylate and dicarboxylate metabolism | GLULA;DHDPSL;GRHPRB;SHMT2;DLDH;HOGA1;MCEE;CS;GRHPRA |
One carbon pool by folate | FTCD;ALDH1L1;MTHFR;MTHFD2;DHFRL1;ST20-MTHFS;TYMS;ALDH1L2;MTHFD2L |
Metabolic pathways | PPAP2C;ALG5;MGAT3;C1GALT1;GAD1;AKR1B7;CMPK1;GK;HMGCR |
Carbon metabolism | FH;PCCA;ALDOB;GOT2A;PSPH;GPT;HK3;MDH1;GPIB |
Biosynthesis of amino acids | GOT1;PGK2;CTH;PGAM1B;MAT1A;PFKMA;PRPS1B;PFKP;GPT |
SHMT2 has several biochemical functions, for example, L-allo-threonine aldolase activity, amino acid binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHMT2 itself. We selected most functions SHMT2 had, and list some proteins which have the same functions with SHMT2. You can find most of the proteins on our site.
Function | Related Protein |
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L-allo-threonine aldolase activity | SHMT2;THA1;SHMT1 |
amino acid binding | SHMT2;TPH1A;TPH2;AGXT;PAH;DDC;TDO2;GOT2;DDAH1 |
chromatin binding | CBFA2T3;TCF7L1B;PELP1;NOC2L;TPR;GATA4;MPO;GABPA;FOS |
glycine hydroxymethyltransferase activity | SHMT1;SHMT2 |
identical protein binding | RELA;CIDEB;EWSR1;DNMT3A;PARK7;ATG101;PRPS2;USP2;MAP3K11 |
protein binding | SEC14L4;BID;POLRMT;ECHS1;RNF126;TRIM59;PRDM14;ATP5A1;KDM2B |
pyridoxal phosphate binding | TAT;SPTLC1;CSAD;SPTLC2A;LOC650128;PDXDC2P;PDXDC1;MARC1;MARC2 |
SHMT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHMT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHMT2.
ARL6IP1; CMTM5; DEGS1; EIF1B; HLA-B; BRCC3; EIF6; GNAS; IKBKE; TRMT10C; NDRG1; DDA1; UBA5; BABAM1; BRE; TNFRSF10D
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