kcnab1
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  • Official Full Name
  • potassium voltage-gated channel, shaker-related subfamily, beta member 1
  • Background
  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.
  • Synonyms
  • KCNAB1; potassium voltage-gated channel, shaker-related subfamily, beta member 1; voltage-gated potassium channel subunit beta-1; AKR6A3; hKvb3; hKvBeta3; KCNA1B; Kvb1.3; K(+) channel subunit beta-1; potassium channel beta 3 chain; potassium channel beta3
Cat.#:KCNAB1-231HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KCNAB1, His-tagged
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Cat.#:KCNAB1-8478MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KCNAB1 Protein
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Cat.#:KCNAB1-3169RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNAB1 Protein
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Cat.#:KCNAB1-2346RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KCNAB1 Protein, His-tagged
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Cat.#:KCNAB1-6468CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KCNAB1
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Cat.#:KCNAB1-5075HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KCNAB1 293 Cell Lysate
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Involved Pathway

KCNAB1 involved in several pathways and played different roles in them. We selected most pathways KCNAB1 participated on our site, such as Neuronal System, Potassium Channels, Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNAB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuronal System
KCNK1; GJA10; CPLX2L; NCALDA; SNAP25A; CHRNA1; DLG1L; GLS2B; KCNH2A; PANX1
Potassium Channels
KCNAB3; KCNN4; KCNA7; KCNK10B; KCNC4; KCNQ3; KCNA5; KCNK3A; KCNV2; KCNG3
Voltage gated Potassium channels
KCNG4A; KCNC1B; KCNS2; KCNC2; KCNAB1A; KCNA6A; KCNF1A; KCNC3A; KCNQ3; KCNC4
metapathway biotransformation
CYP4V2; NAA40; CYP20A1; KCNAB3; SULT1B1; SULT4A1; GAL3ST3; NAA20; HS3ST4; CYP4Z1

Protein Function

KCNAB1 has several biochemical functions, for example, NADPH binding, aldo-keto reductase (NADP) activity, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNAB1 itself. We selected most functions KCNAB1 had, and list some proteins which have the same functions with KCNAB1. You can find most of the proteins on our site.
Function
Related Protein
Function NADPH binding
Related Protein QDPR; KCNAB1; DHFR; TP53I3; CBR3; CBR4; DECR1; GRHPR; HMGCR; MTRR
Function aldo-keto reductase (NADP) activity
Related Protein AKR1B1; KCNAB2; H2-KE6; AKR7A3; CYB5A; HSD11B1LA; AKR1C21; AKR1C3; AKR1C4; SDR42E1
Function ion channel binding
Related Protein RANGRF; USP10; HTT; SCN3B; FKBP1B; FYN; PACS1A; PACS2; KCNB2; VDAC1
Function potassium channel regulator activity
Related Protein AMIGO1; KCNMB2; KCNIP2; KCNAB1; KCNMB3; KCNE1L; KCNE2; CHP; KCNIP1; LRRC26
Function voltage-gated potassium channel activity
Related Protein KCNH2A; KCNA2B; KCNT1; KCNQ5; KCNAB2; KCNC3B; KCNS3A; KCNK9; KCND2; KCNC1B

Interacting Protein

KCNAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNAB1.
SRPK1; ssdna_dtdg; ARRB2

KCNAB1 Related Articles

Lu, AG; Tang, Y; et al. Brain genomics of intracerebral hemorrhage. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 26:230-252(2006).
Nakahira, K; Shi, GY; et al. Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits. JOURNAL OF BIOLOGICAL CHEMISTRY 271:7084-7089(1996).