MAFA
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Official Full Name
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
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Overview
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008] -
Synonyms
MAFA; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; hMafA; RIPE3b1; transcription factor MafA; transcription factor RIPE3b1; pancreatic beta-cell-specific transcriptional activator;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- HEK293
- Mammalian Cell
- Wheat Germ
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | MAFA-28859TH | Recombinant Human MAFA | Wheat Germ | N/A | 87 amino acids |
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| Human | MAFA-4562HCL | Recombinant Human MAFA 293 Cell Lysate | HEK293 | N/A |
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| Mouse | MAFA-9437M | Recombinant Mouse MAFA Protein | Mammalian Cell | His |
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| Mouse | MAFA-5296M-B | Recombinant Mouse MAFA Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | MAFA-5296M | Recombinant Mouse MAFA Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Zebrafish | MAFA-5302Z | Recombinant Zebrafish MAFA | Mammalian Cell | His |
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| Chicken | MAFA-6582C | Recombinant Chicken MAFA | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- MAFA Related Articles
MAFA involved in several pathways and played different roles in them. We selected most pathways MAFA participated on our site, such as Type II diabetes mellitus, Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAFA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Type II diabetes mellitus | IKBKB;PIK3CG;CACNA1G;INS1;IRS1;IRS2;MAPK1;PKLR;SOCS2 |
| Maturity onset diabetes of the young | NKX6-1;INS;HNF1B;BHLHA15;FOXA2;HHEX;SLC2A2;NR5A2;IAPP |
MAFA has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAFA itself. We selected most functions MAFA had, and list some proteins which have the same functions with MAFA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HMG20B;SMAD3A;TIGD2;ZNF2;HIST1H111R;EPAS1B;SURF6;FBXL19;MIER3 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | MYF5;GLI2;MEOX1;JUND;BCL11A;ZNF331;ELK1;ZNF543;FOSL2 |
| protein heterodimerization activity | HIST2H4A;TRP53;TWIST1;ALX1;APOA2;HER11;CUL3;CENPA;ITGB1 |
| protein homodimerization activity | HLA-G;BHLHA15;YARS2;PDGFB;IKBKG;EFR3A;VWF;B4GALT1;SYT16 |
| transcription factor activity, sequence-specific DNA binding | ZNF131;FOXG1;HSF5;SALL1;ZFP1;NR1D4B;HOXB5A;SMAD2;RELA |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | SIX1;ZNF750;MAFB;ETV1;MEOX1;ESRRA;CEBPG;JUNB;CEBPE |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | GRHL3;MAFA;MAFGB;MAFBA;GATA5;SOHLH1;FEZF2;GRHL2;MAFGA |
MAFA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAFA here. Most of them are supplied by our site. Hope this information will be useful for your research of MAFA.
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