This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver.
PANK3 involved in several pathways and played different roles in them. We selected most pathways PANK3 participated on our site, such as Pantothenate and CoA biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PANK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
PANK3 has several biochemical functions, for example, ATP binding, pantothenate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PANK3 itself. We selected most functions PANK3 had, and list some proteins which have the same functions with PANK3. You can find most of the proteins on our site.
Function ATP binding
Related Protein DNAJA3; ATP2C2; ERCC2; LRRK1; DCLK3; SLC14A2; YES1; SEPHS2; SRR; DDX28
Function pantothenate kinase activity
Related Protein PANK3; PANK1B; PANK2; PANK1; PANK4
PANK3 Related Articles
Li, MH; Liu, ZJ; et al. miR-103 promotes 3T3-L1 cell adipogenesis through AKT/mTOR signal pathway with its target being MEF2D. BIOLOGICAL CHEMISTRY 396:235-244(2015).
Dwarakanath, S; Zafar, A; et al. Does lesioning surgery have a role in the management of multietiological tremor in the era of Deep Brain Stimulation?. CLINICAL NEUROLOGY AND NEUROSURGERY 125:131-136(2014).