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POLR2B

Official Full Name

polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
Overview

This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA.
Synonyms

POLR2B; polymerase (RNA) II (DNA directed) polypeptide B, 140kDa; polymerase (RNA) II (DNA directed) polypeptide B (140kD); DNA-directed RNA polymerase II subunit RPB2; RPB2; RNA polymerase II subunit 2; RNA polymerase II subunit B2; DNA-directed RNA poly;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Mouse
Rhesus Macaque
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	POLR2B-13092M	Recombinant Mouse POLR2B Protein	Mammalian Cell	His	Inquiry
Mouse	POLR2B-6921M	Recombinant Mouse POLR2B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	POLR2B-6921M-B	Recombinant Mouse POLR2B Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	POLR2B-3513R	Recombinant Rhesus monkey POLR2B Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	POLR2B-3331R-B	Recombinant Rhesus Macaque POLR2B Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	POLR2B-3331R	Recombinant Rhesus Macaque POLR2B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	POLR2B-3048Z	Recombinant Zebrafish POLR2B	Mammalian Cell	His	Inquiry
Chicken	POLR2B-1588C	Recombinant Chicken POLR2B	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
POLR2B Related Articles

POLR2B involved in several pathways and played different roles in them. We selected most pathways POLR2B participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	NPR2;PDE7B;CANT1B;POLR2EB;PRPS1A;AMPD1;AK9;PNP6;POLA2
Pyrimidine metabolism	CMPK1;ENTPD3;NT5C2B;TRR1;CTPS2;TYMS;UCK2B;POLR3D;DHODH
Metabolic pathways	UGT1A7C;ALPI.2;FAHD1;PDHB;PTGS2A;BTD;ST20-MTHFS;LDHAL6A;ACAA1
RNA polymerase	POLR1C;POLR2J2;POLR3D;POLR2H;POLR1E;POLR2K;POLR3B;TWISTNB;POLR3GL
Huntingtons disease	NDUFB4;ATP5C1;CREB3L3;CASP8;NDUFB7;COX6B2;COX7A2L;NDUFA7;GRIN1
Epstein-Barr virus infection	PLCG1;HDAC2;HLA-E;GTF2E1;HLA-F;POLR1C;CCNA1;NFKBIE;SKP2

POLR2B has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase II activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2B itself. We selected most functions POLR2B had, and list some proteins which have the same functions with POLR2B. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	HOXC3A;GABPA;NR5A5;TRIM16;ZNF689;MGAA;MEIS2A;ZNF581;TLX3B
DNA-directed RNA polymerase activity	POLR2EB;CRCP;CD3EAP;POLR3A;POLR3C;POLR2L;POLRMT;POLR2E;POLR2GL
contributes_to RNA polymerase II activity	POLR2L;POLR2J;POLR2EB;POLR2A;POLR2K;POLR2E;POLR2B;POLR2J2;POLR2C
chromatin binding	NOC3L;KDM6B;JUB;SP3;PYGO2;SREBF1;MECP2;SETD7;MTA3
metal ion binding	FAM96A;EBF1;PRKCBP1L;ZFP551;ADAP1;ZNF394;ZBTB20;KIT;PRDM8
nucleotidyltransferase activity	GMPPAB;POLE2;MOCS3;GMPPA;TAMM41;CCDC111;POLN;GDPGP1;OASL2
poly(A) RNA binding	PTCD3;SEC23IP;RDBP;GNL3L;ZC3H10;S100A16;BYSL;LUC7L2;RPL30
ribonucleoside binding	POLR2B;POLR3B
transferase activity	LMTK2;MAT2AL;TAB3;CHST2A;TRMT12;UGT1A7C;CHST3B;ST3GAL2L;PGGT1B

POLR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2B.

Nphp4; Ywhae; Tfcp2l1; Ezh2; Nanog; Tada2a; Kat2a; Aire

Sun, YY; Li, SS; et al. TNFRSF10A-LOC389641 rs13278062 But Not REST-C4orf14-POLR2B-IGFBP7 rs1713985 Was Found Associated With Age-Related Macular Degeneration in a Chinese Population. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:8199-8203(2013).

Zhou, J; Wang, D; et al. RAD51 gene is associated with advanced age-related macular degeneration in Chinese population. CLINICAL BIOCHEMISTRY 46:1689-1693(2013).