Creative BioMart to Present at IMMUNOLOGY2024™|May 3-7, 2024|Booth #512 Learn More

SIAH1

Official Full Name

seven in absentia homolog 1 (Drosophila)
Overview

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinsons disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Synonyms

SIAH1; seven in absentia homolog 1 (Drosophila); E3 ubiquitin-protein ligase SIAH1; hSIAH1; HUMSIAH; Seven in absentia homolog 1; SIAH 1; Siah 1a; Ubiquitin ligase SIAH1; siah-1a; OTTHUMP00000164188; OTTHUMP00000164189; SIAH1A;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SIAH1-2668H	Recombinant Human SIAH1, GST-tagged	E.coli	GST	1-282aa	$319 / 25ug
Human	SIAH1-1851HCL	Recombinant Human SIAH1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SIAH1-4629H	Recombinant Human SIAH1 protein, GST-tagged	E.coli	GST	1-313aa	Inquiry
Rhesus Macaque	SIAH1-4200R	Recombinant Rhesus monkey SIAH1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SIAH1-4016R	Recombinant Rhesus Macaque SIAH1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SIAH1-4016R-B	Recombinant Rhesus Macaque SIAH1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SIAH1-9929Z	Recombinant Zebrafish SIAH1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SIAH1 Related Research Area

SIAH1 involved in several pathways and played different roles in them. We selected most pathways SIAH1 participated on our site, such as p signaling pathway, Ubiquitin mediated proteolysis, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIAH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
p signaling pathway	GADD45BA;SERPINB5;TNFRSF10B;COP1;CCND2;TP73;BBC3;CASP3B;Casp3
Ubiquitin mediated proteolysis	BRCA1;UBE2D1B;UBOX5;TRIM37;SOCS1A;CUL3B;UBE2G1B;CDC23;UBE2I
Wnt signaling pathway	WNT4;FRAT2;PRKACBB;WNT6;SOX17;NKD2;GSK3B;WNT7B;PPP3CC

SIAH1 has several biochemical functions, for example, identical protein binding, ligase activity, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIAH1 itself. We selected most functions SIAH1 had, and list some proteins which have the same functions with SIAH1. You can find most of the proteins on our site.

Function	Related Protein
identical protein binding	L3MBTL1;SMAD4;GYPA;VPS4B;NELL2;DPP9;SSNA1;CHAF1A;ROBO1
ligase activity	TTLL4;G2E3;PJA1;LIG4;ZNRF2B;UBE2I;RTCB;PJA2;TRIM4
protein C-terminus binding	PHB;VGLL2;ATXN2;NEIL1;SHANK1;BLOC1S2A;PEX10;PEX1;VTA1
protein binding	ARFIP2;MOV10;ATG12;DPM2;MAGEA2;MED27;MPZL2B;GSTA2;PDCD4
ubiquitin protein ligase activity	LRSAM1;MED27;MED31;FANCF;FBXW11;RABGEF1;RNF144A;RNF146;NEURL3
ubiquitin-protein transferase activity	MKRN1;SIAH1;UBE2E1;RNF6;RNF115;UBA1;FBXO4;MIB2;MARCH8
zinc ion binding	MT1A;TRIM74;ZFHX3;TRIM15;GM3258;ZDHHC19;FBXO30A;PDLIM1;TRPS1

SIAH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIAH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIAH1.

PHC2; PUF60; EEF1D; UBE2K

Notch Pathway