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SLBP

Official Full Name

stem-loop binding protein
Overview

The SLPB gene (stem-loop binding protein) encodes a protein that binds to the stem-loop structure of replication-dependent histone pre-mRNAs. Histone mRNA lack a polyadenylation signal. Consequently, the interaction of this protein with histone pre-mRNA contributes to efficient 3' end processing by stabilizing the complex between the pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP). Expression of this protein is regulated during the cell cycle,Increasing more than 10-fold during the latter part of G1.
Synonyms

SLBP; stem-loop binding protein; stem loop (histone) binding protein; histone RNA hairpin-binding protein; HBP; histone binding protein; hairpin binding protein, histone; histone stem-loop binding protein; histone stem-loop-binding protein; stem-loop (histone) binding protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

C
Myc
DDK
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SLBP-7795H	Recombinant Human SLBP, His-tagged	HEK293	His	Inquiry
Human	SLBP-596HCL	Recombinant Human SLBP lysate	HEK293	N/A	Inquiry
Human	SLBP-01H	Recombinant Human SLBP Protein, C-Myc/DDK-tagged	HEK293T	C-Myc/DDK	Inquiry
Mouse	SLBP-15198M	Recombinant Mouse SLBP Protein	Mammalian Cell	His	Inquiry
Mouse	SLBP-8209M-B	Recombinant Mouse SLBP Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	SLBP-8209M	Recombinant Mouse SLBP Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	Slbp-5901M	Recombinant Mouse Slbp Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Zebrafish	SLBP-8123Z	Recombinant Zebrafish SLBP	Mammalian Cell	His	Inquiry
Zebrafish	SLBP-8124Z	Recombinant Zebrafish SLBP	Mammalian Cell	His	Inquiry
Chicken	SLBP-1221C	Recombinant Chicken SLBP	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

SLBP involved in several pathways and played different roles in them. We selected most pathways SLBP participated on our site, such as Cleavage of Growing Transcript in the Termination Region, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cleavage of Growing Transcript in the Termination Region	CLP1;LSM11;SRSF11;LSM10;NUDT21;RNPS1;CSTF3;ZFP473;CSTF2
Gene Expression	CSTF1;ZNF671;ZNF155;PPARAA;POP1;ZFP2;NR2E3;ZNF620;ZNF133
Processing of Capped Intron-Containing Pre-mRNA	CLP1;TXNL4A;RNPS1;SNRNP35;CD2BP2;ZCRB1;YBX1;NUDT21;CCAR1
Processing of Capped Intronless Pre-mRNA	PAPOLA;CSTF1;CSTF2;SLBP;CLP1;ZFP473;NUDT21;LSM11;ZNF473
RNA Polymerase II Transcription	SSRP1A;ZFP473;NELFE;SRSF11;RNPS1;CLP1;SUPT16H;THOC4;CCNT2A
RNA Polymerase II Transcription Termination	ZNF473;LSM11;ZFP473;SLBP;CSTF2;SRSF11;CLP1;RNPS1;CSTF3
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	ZFP473;LSM11;LSM10;ZNF473;SLBP
Transport of Mature Transcript to Cytoplasm	SLBP;SRSF11;NXF1;U2AF2;SFRS3A

SLBP has several biochemical functions, for example, histone pre-mRNA DCP binding, histone pre-mRNA stem-loop binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLBP itself. We selected most functions SLBP had, and list some proteins which have the same functions with SLBP. You can find most of the proteins on our site.

Function	Related Protein
histone pre-mRNA DCP binding	SNRPB;SLBP;LSM10;SNRPD3
histone pre-mRNA stem-loop binding	SLBP;ERI1
mRNA binding	KIAA0020;CELF1;NXF2;FMR1;NXF3;FYTTD1;FXR1;NCBP2;DPPA5A
poly(A) RNA binding	UBE2I;HDAC2;NCBP1;UCHL5;UBE2N;CS;EMG1;EIF2C3;CCT4
protein binding	DDX39B;E2F4;ASUN;TRAF7;MLH1;RNF4;ARHGEF40;ID3;LGR4

SLBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLBP here. Most of them are supplied by our site. Hope this information will be useful for your research of SLBP.

CDK4; CDK6; stem_loop_rna; ZNF473; TACC3