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SRY

Official Full Name

Sex Determining Region Y
Overview

This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.
Synonyms

SRY; sex determining region Y; TDF; TDY; SRXX1; SRXY1; sex-determining region Y protein; testis-determining factor; sex-determining region on Y; sex determining region protein; essential protein for sex determination in human males; OTTHUMP00000034324;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SRY-1469HCL	Recombinant Human SRY 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SRY-454H	Recombinant Human SRY Protein, His-tagged	E.coli	His	Met1~Leu204	$298 / 10ug
Mouse	SRY-16019M	Recombinant Mouse SRY Protein	Mammalian Cell	His		Inquiry
Mouse	SRY-8738M	Recombinant Mouse SRY Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SRY-819M	Recombinant Mouse SRY Protein (1-144 aa), His-tagged	E.coli	His	1-144 aa	Inquiry
Mouse	SRY-8738M-B	Recombinant Mouse SRY Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	SRY-4480R	Recombinant Rhesus monkey SRY Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SRY-4296R	Recombinant Rhesus Macaque SRY Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SRY-4296R-B	Recombinant Rhesus Macaque SRY Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
SRY Related Articles

SRY involved in several pathways and played different roles in them. We selected most pathways SRY participated on our site, such as Deactivation of the beta-catenin transactivating complex, Regulation of Androgen receptor activity, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRY were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Deactivation of the beta-catenin transactivating complex	CBY1;SOX13;SOX7;TLE2;BCL9L;SOX4A;ASH2L;TLE3B;PYGO1
Regulation of Androgen receptor activity	SMARCA2;APPBP2;NR2C2;SPDEF;SMARCE1;NR0B1;HOXB13;KAT7;GATA2
Signal Transduction	ARHGAP31;MKL1;TMED5;RLN2;RGS10;PTH;GPR132B;DTX2;BOC
Signaling by Wnt	LGR4;ROR2;PYGO1;ROR1;DACT1;FAM123B;RNF146;SOX7;SOX9A
TCF dependent signaling in response to WNT	PYGO1;HECW1B;ASH2L;SRY;ZNRF3;SOX4A;SOX7;LEO1;C

SRY has several biochemical functions, for example, DNA binding, DNA binding, bending, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRY itself. We selected most functions SRY had, and list some proteins which have the same functions with SRY. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	HOXB4A;HIST1H2BC;IRF6;HIST1H4I;RPP21;ZFAND6;FUZ;PBRM1;NKX2.4B
DNA binding, bending	SRY;TOP2A;TFAM;FOXD1;LEF1;HMGA2;TOP2B;FOXD4;HMGB3
calmodulin binding	PATE4;MYH10;TRPV5;CAMK1D;ATPIF1;ENKUR;MYO5C;SLC9A1;MYH13
protein heterodimerization activity	PIK3R1;HAND1;UBA2;CXCL13;UGT1A9;DRD1A;FLOT1;AGTR1;GCLC
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	MYOG;BHLHE40;TLE4;NKX2-1;FOXF2A;GATA6;SOX10;SOX9;MYF6
transcription factor binding	NR0B2A;FIGLA;HOXA7;PBX1;BRD7;PARD6A;GATA4;KAT2B;AHR

SRY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRY here. Most of them are supplied by our site. Hope this information will be useful for your research of SRY.

SLC9A3R2; SMAD3

Willis, BC; Johnson, G; et al. SOX10: A Useful Marker for Identifying Metastatic Melanoma in Sentinel Lymph Nodes. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 23:109-112(2015).

Frisch, J; Venkatesan, JK; et al. Determination of the Chondrogenic Differentiation Processes in Human Bone Marrow-Derived Mesenchymal Stem Cells Genetically Modified to Overexpress Transforming Growth Factor-beta via Recombinant Adeno-Associated Viral Vectors. HUMAN GENE THERAPY 25:1050-1060(2014).