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SUDS3

Official Full Name

suppressor of defective silencing 3 homolog (S. cerevisiae)
Overview

SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex;(Fleischer et al., 2003 (PubMed 12724404)).
Synonyms

SUDS3; suppressor of defective silencing 3 homolog (S. cerevisiae); suppressor of defective silencing 3 homolog (SDS3, S. cerevisiae); sin3 histone deacetylase corepressor complex component SDS3; FLJ00052; SAP45; SDS3; sin3A associated protein; 45kDa; 2400003N08Rik; 2410008L21Rik; 45 kDa Sin3 associated polypeptide; AU067672; MGC104711; mSds3; RGD1305986; SDS3, yeast, homolog of; Sin3A associated protein 45kDa; Suppressor of defective silencing 3; Suppressor of defective silencing 3 homolog (S cerevisiae); Suppressor of defective silencing 3 homolog (SDS3 S cerevisiae); Suppressor of defective silencing 3 protein homolog; sin3A-associated protein, 45kDa; 45 kDa Sin3-associated polypeptide;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SUDS3-1363HCL	Recombinant Human SUDS3 293 Cell Lysate	HEK293	N/A	Inquiry
Human	SUDS3-6384H	Recombinant Human SUDS3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	SUDS3-16212M	Recombinant Mouse SUDS3 Protein	Mammalian Cell	His	Inquiry
Mouse	SUDS3-8855M	Recombinant Mouse SUDS3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	Suds3-6217M	Recombinant Mouse Suds3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Mouse	SUDS3-8855M-B	Recombinant Mouse SUDS3 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	SUDS3-936Z	Recombinant Zebrafish SUDS3	Mammalian Cell	His	Inquiry
Chicken	SUDS3-3118C	Recombinant Chicken SUDS3	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SUDS3 Related Articles

SUDS3 involved in several pathways and played different roles in them. We selected most pathways SUDS3 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUDS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	PHF20B;C3orf75;PADI1;AEBP2;PAX3A;MTA2;KAT7;ING5A;SAP130
Chromatin organization	PADI3;SMARCA2;SMARCD3;SMYD2;EHMT2;SMARCB1A;ACTL6B;KDM5A;DNMT3A
Epigenetic regulation of gene expression	H3F3B.1;SUZ12;TAF1A;H3F3D;SAP130;JARID2B;JARID2;SAP18;TAF1D
Gene Expression	NRBF2;ZNF706;SESN3;ZNF705A;ZNF471;ZNF302;ZNF688;ZNF713;TSEN34
HDACs deacetylate histones	ARID4A;MTA2;MBD3B;GATAD2A;MBD3A;GATAD2B;MBD3;CHD4;CHD4A
Negative epigenetic regulation of rRNA expression	SAP30;SIN3B;SAP130;TAF1C;TAF1A;SUDS3;BAZ2A;EFCAB11;RRP8
NoRC negatively regulates rRNA expression	SAP30L;SAP30BP;DNMT3B;SAP130;SUDS3;TAF1C;SIN3B;TAF1D;BAZ2A

SUDS3 has several biochemical functions, for example, enzyme binding, contributes_to histone deacetylase activity, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUDS3 itself. We selected most functions SUDS3 had, and list some proteins which have the same functions with SUDS3. You can find most of the proteins on our site.

Function	Related Protein
enzyme binding	RPA2;ARRB2;SELS;HSPA8;AXIN2;ATP2A2;ZFP346;MLEC;PEX7
contributes_to histone deacetylase activity	BRMS1;SIN3A;SIN3B;SIN3AA;BRMS1L;SUDS3;SALL1;BRMS1LA
histone deacetylase binding	CBX5;MEF2B;MAGEA2;NR2C1;KPNA2;NRIP1;NUDT21;ZNF703;YY1
protein binding	ALKBH8;JAM2;ZBTB24;PDIK1L;CAND1;CCDC36;WBP4;PLIN5;RHEB

SUDS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUDS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUDS3.

HDAC1; BRMS1; HCFC1; CSNK2A1; LRRK2; SRPK1; SAP30; Tet1; Sin3a; Fam60a; HDAC2

Zhang, K; Dai, XP; et al. Depletion of Suds3 reveals an essential role in early lineage specification. DEVELOPMENTAL BIOLOGY 373:359-372(2013).

Silveira, AC; Hurst, DR; et al. Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells. CANCER LETTERS 276:32-37(2009).