tfb1m
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  • Official Full Name
  • transcription factor B1, mitochondrial
  • Background
  • The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).
  • Synonyms
  • TFB1M; transcription factor B1, mitochondrial; dimethyladenosine transferase 1, mitochondrial; CGI 75; dimethyladenosine transferase 1; mitochondrial; mtTFB; hmtTFB; hmtTFB1; hTFB1M; Mitochondrial 12S rRNA dimethylase 1; Mitochondrial transcription factor B1; mtTFB1; h-mtTFB; h-mtTFB1; Mitochondrial dimethyladenosine transferase 1; TFB1M_HUMAN; Transcription factor B1 mitochondrial; homolog of yeast mitochondrial transcription factor B; S-adenosylmethionine-6-N, N-adenosyl(rRNA) dimethyltransferase 1; CGI75; CGI-75
Cat.#:TFB1M-3619HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TFB1M, His-tagged
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Cat.#:TFB1M-1785HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transcription Factor B1, Mitochondrial, His-tagged
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Cat.#:TFB1M-3194HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TFB1M, GST-tagged
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Cat.#:TFB1M-16682MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TFB1M Protein
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Cat.#:TFB1M-6025RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TFB1M Protein
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Cat.#:TFB1M-1016CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TFB1M Protein, His-tagged
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Cat.#:TFB1M-4676RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TFB1M Protein, His-tagged
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Cat.#:TFB1M-4594ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TFB1M
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Cat.#:TFB1M-1136HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TFB1M 293 Cell Lysate
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Involved Pathway

TFB1M involved in several pathways and played different roles in them. We selected most pathways TFB1M participated on our site, such as Energy Metabolism, Mitochondrial Gene Expression, Mitochondrial biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFB1M were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Energy Metabolism
UCP2; TFB1M; PPARGC1B; TFB2M; UCP3; GABPA; MEF2B; ESRRA; MYBBP1A
Mitochondrial Gene Expression
POLRMT; TFB1M; ESRRA; TFB2M; MTERFD1; PPRC1; PPARGC1B
Mitochondrial biogenesis
TFB1M; C10orf2; TFB2M; PPRC1; POLRMT; GABPB1; ESRRA; POLG2; MTERF; GABPA
Organelle biogenesis and maintenance
IFT122; NPHP4; ICT1; CNGA5; CC2D2A; BBS1; IFT172; TUFM; MRPL47; WDR19
Transcriptional activation of mitochondrial biogenesis
C10orf2; POLG2; PPRC1; MTERF; POLRMT; GABPB1; GABPA; TFB1M

Protein Function

TFB1M has several biochemical functions, for example, DNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFB1M itself. We selected most functions TFB1M had, and list some proteins which have the same functions with TFB1M. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein PAX6B; HDGF; PAX2B; NKX1.2LA; ZBTB7A; HOXB2; DNTTIP1; PAX7B; LIN28A; SAFB2
Function poly(A) RNA binding
Related Protein THRAP3; CALR; RPS25; HIST1H47; KHSRP; SRSF5; RPL8; PEF1; RPS7; CSRP1
Function protein binding
Related Protein ITM2B; MMRN2; GNB3; ITGA1; RAP2A; UNC13D; PVRL4; TDG; MAP2; RPS25
Function rRNA (adenine-N6,N6-)-dimethyltransferase activity
Related Protein RNMTL1A; RNMTL1B; FBLL1; RRNAD1; TRMT10C; PRDM13; METTL23; METTL21A; METTL21D; TFB2M

Interacting Protein

TFB1M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFB1M here. Most of them are supplied by our site. Hope this information will be useful for your research of TFB1M.
TFAM; s-adenosyl-l-methionine-1; POLRMT; Srp72; AP4M1; RPL10; YWHAH; ICT1; Rpl35; BAIAP2

TFB1M Related Articles

Nabokina, SM; Valle, JE; et al. Characterization of the human mitochondrial thiamine pyrophosphate transporter SLC25A19 minimal promoter: A role for NF-Y in regulating, basal transcription. GENE 528:248-255(2013).