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TSEN2

  • Official Full Name

    tRNA splicing endonuclease 2 homolog (S. cerevisiae)

  • Overview

    This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    TSEN2; tRNA splicing endonuclease 2 homolog (S. cerevisiae); tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae); tRNA-splicing endonuclease subunit Sen2; MGC2776; SEN2; SEN2L; HsSen2; MGC4440; tRNA intron endonuclease Sen2; tRNA splicing endonuclease subunit Sen2; TSEN 2; tRNA-intron endonuclease Sen2; PCH2B;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TSEN2-1843HCL Recombinant Human TSEN2 cell lysate N/A
Human TSEN2-2803H Recombinant Human TSEN2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TSEN2-3157H Recombinant Human TSEN2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse TSEN2-17480M Recombinant Mouse TSEN2 Protein Mammalian Cell His
Mouse TSEN2-9668M-B Recombinant Mouse TSEN2 Protein Pre-coupled Magnetic Beads HEK293
Mouse TSEN2-9668M Recombinant Mouse TSEN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TSEN2-6313R Recombinant Rat TSEN2 Protein Mammalian Cell His
Rat TSEN2-5970R-B Recombinant Rat TSEN2 Protein Pre-coupled Magnetic Beads HEK293
Rat TSEN2-5970R Recombinant Rat TSEN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish TSEN2-4533Z Recombinant Zebrafish TSEN2 Mammalian Cell His
Chicken TSEN2-2307C Recombinant Chicken TSEN2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TSEN2 Related Articles

TSEN2 involved in several pathways and played different roles in them. We selected most pathways TSEN2 participated on our site, such as Gene Expression, tRNA processing, tRNA processing in the nucleus, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSEN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionDNAJC8;TYW3;ZNF480;NR2C2AP;TEAD1A;ZNF445;RPP14;ZNF560;ADARB1A
tRNA processingTSEN15;LBH;POP4;TSEN54;LAGE3;TYW5;RPP14;TPRKB;TSEN34
tRNA processing in the nucleusPOP1;RPP30;C2orf49;C14orf166;TSEN54;TSEN34;ELAC2;POP7;RPP40

TSEN2 has several biochemical functions, for example, lyase activity, nucleic acid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSEN2 itself. We selected most functions TSEN2 had, and list some proteins which have the same functions with TSEN2. You can find most of the proteins on our site.

Function Related Protein
lyase activityPDXDC1;TSEN2;ECHDC2;IRG1L;ALDOAA;MOCOS;GC2;AGXT2L2;ENO2
nucleic acid bindingRBM4.2;ZFP410;REXO1;CCDC75;U2AF2B;ZNF740B;CNOT4B;BLF;ZBTB7C
protein bindingCRYBA4;SEPT12;SEMA7A;BCL10;EIF3H;VAC14;STYX;NLRX1;CLSTN1
tRNA-intron endonuclease activityTSEN2;TSEN15;TSEN34

TSEN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSEN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSEN2.

TSEN54; Clp1

Hu, QD; Lu, H; et al. A human homolog of the yeast gene encoding tRNA 2 '-phosphotransferase: cloning, characterization and complementation analysis. CELLULAR AND MOLECULAR LIFE SCIENCES 60:1725-1732(2003).
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