VARS
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Official Full Name
valyl-tRNA synthetase
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Overview
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. -
Synonyms
VARS; valyl-tRNA synthetase; valyl tRNA synthetase 2 , VARS2; valine tRNA ligase 1; cytoplasmic; Bat 6; Bat6; D17H6S56E; EC 6.1.1.9; G7A; Protein G7a; SYVC_HUMAN; Valine tRNA ligase; Valine--tRNA ligase; ValRS; VALYL tRNA SYNTHETASE 1; valyl tRNA synthetase 2; Vars1; VARS2; OTTHUMP00000029422; valyl-tRNA synthetase 2; valine tRNA ligase 1, cytoplasmic;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | VARS-3647H | Recombinant Human VARS, His-tagged | E.coli | His | 916-1264aa | |
| Human | VARS-8221H | Recombinant Human VARS protein, His & T7-tagged | E.coli | His/T7 | Ser2~Gln219 (Accession # P26640) |
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| Human | VARS-121H | Recombinant Human VARS Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | VARS-1120H | Recombinant Human VARS Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Mouse | Vars-8222M | Recombinant Mouse Vars protein, His & T7-tagged | E.coli | His/T7 | Asn186~Glu421 (Accession # Q9Z1Q9) |
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| Rat | VARS-6500R | Recombinant Rat VARS Protein | Mammalian Cell | His |
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| Rat | VARS-6156R-B | Recombinant Rat VARS Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | VARS-6156R | Recombinant Rat VARS Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
VARS involved in several pathways and played different roles in them. We selected most pathways VARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | TARS;YARS2;DARS;SARS;WARS;HARS;RARS2;KARS;IARS2 |
VARS has several biochemical functions, for example, ATP binding, aminoacyl-tRNA editing activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VARS itself. We selected most functions VARS had, and list some proteins which have the same functions with VARS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | YARS;RAD51D;MARS;NSF;DYRK1A;PDPK1A;NLRC4;KIF20B;AK5 |
| aminoacyl-tRNA editing activity | LARS;PRORSD1;LARS2;AARS;DTD1;IARS2;IARS;VARS;VARS2 |
| protein binding | RBM25;CENPO;KLHDC5;TBC1D17;HDAC4;PDIA3;TXNL4A;CXCL9;EIF1AX |
| valine-tRNA ligase activity | VARS2;VARS |
VARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VARS here. Most of them are supplied by our site. Hope this information will be useful for your research of VARS.
CALCOCO2; SGK1; EPB41; TFE3; MCC; HLA-B; VHL; YWHAZ; EEF1A2; DMWD; OTUD5; ATG101; TNFRSF10D; TRAF6; IKBKG; CACNA1A; dppA; 15-deoxy-delta(12,14
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