aplp2
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  • Official Full Name
  • amyloid beta (A4) precursor-like protein 2
  • Background
  • This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimers disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • APLP2; amyloid beta (A4) precursor-like protein 2; amyloid-like protein 2; amyloid beta (A4) precursor like protein 2; Amyloid like protein 2; amyloid precursor protein homolog HSD2; Amyloid protein homolog; APLP-2; APLP2_HUMAN; APPH; APPL2; CDEBP; CDEI box binding protein; CDEI box-binding protein; amyloid precursor protein homolog HSD-2
Cat.#:APLP2-2283HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human APLP2 Protein, MYC/DDK-tagged
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Cat.#:APLP2-395HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APLP2 Protein, His-tagged
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Cat.#:APLP2-688HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APLP2 protein, GST-tagged
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Cat.#:APLP2-9746HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APLP2, GST-tagged
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Cat.#:APLP2-1777MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse APLP2 Protein
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Cat.#:Aplp2-3444RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Aplp2, His-tagged
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Cat.#:APLP2-1462CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken APLP2
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Cat.#:APLP2-6619ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish APLP2
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Cat.#:APLP2-92HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human APLP2 cell lysate
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Protein Function

APLP2 has several biochemical functions, for example, DNA binding, heparin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APLP2 itself. We selected most functions APLP2 had, and list some proteins which have the same functions with APLP2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF302; SS18L1; TOMM20A; ETV5B; NR0B2; PAX2; ZFP292; SLC2A4RG; AHRR; POGZ
Function heparin binding
Related Protein ZFP207; COMP; HBEGF; PLA2G2D; ABI3BP; FGFR1A; POSTN; NELL2; LPL; MMP7
Function identical protein binding
Related Protein CRYBB2; CHAF1A; SCHIP1; COL1A1; ZBTB16; COL1A2; APIP; FADD; Serpina1b; RIPK1
Function protein binding
Related Protein ERCC4; CSF2RB; REG3A; SLC9A3; DLX4; TAF6; ZNF670; WDHD1; GRK5; INTS12
Function serine-type endopeptidase inhibitor activity
Related Protein SPOCK1; OVST; KAL1; ITIH6; MUG1; SERPINH1B; SERPINC1; SERPING1; CD109; SERPINB6
Function transition metal ion binding
Related Protein APLP2; APLP1; APPA; HRSP12; APP; APPB

Interacting Protein

APLP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APLP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APLP2.
JUN; APP; APLP1; DEDD; MED12; ETS1; JUNB; NFKB1; Slc5a7

APLP2 Related Articles

Cheng, F; Cappai, R; et al. Amyloid Precursor Protein (APP)/APP-like Protein 2 (APLP2) Expression Is Required to Initiate Endosome-Nucleus-Autophagosome Trafficking of Glypican-1-derived Heparan Sulfate. JOURNAL OF BIOLOGICAL CHEMISTRY 289:20871-20878(2014).
Peters, HL; Yan, Y; et al. APLP2 regulates the expression of MHC class I molecules on irradiated Ewing's sarcoma cells. ONCOIMMUNOLOGY 2:-(2013).