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AQP5

  • Official Full Name

    aquaporin 5

  • Overview

    Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to;the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary;secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.
  • Synonyms

    AQP5; aquaporin 5; aquaporin-5; AQP 5; AQP-5; AQP5_HUMAN; OTTHUMP00000241927;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Milnesium tardigradum (Water bear) (Tardigrade)
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Pig
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • In vitro E. coli expression system
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • GST
  • Tag
  • Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AQP5-33HCL Recombinant Human AQP5 lysate HEK293 N/A
Human AQP5-0403H Recombinant Human AQP5 protein, His-tagged E.coli His 190-265 aa
Human AQP5-236H Recombinant Human AQP5 Protein, His-tagged E.coli N-His Ser183-Arg265
Human AQP5-222H Recombinant Human AQP5 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-265aa
Mouse AQP5-1824M Recombinant Mouse AQP5 Protein Mammalian Cell His
Mouse AQP5-650M Recombinant Mouse AQP5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Aqp5-237M Recombinant Mouse Aqp5 Protein, His&GST-tagged E.coli N-His&GST Ser183-His265
Mouse AQP5-650M-B Recombinant Mouse AQP5 Protein Pre-coupled Magnetic Beads HEK293
Rat AQP5-739R Recombinant Rat AQP5 Protein Mammalian Cell His
Rat Aqp5-3601R Recombinant Rat Aqp5, His-tagged E.Coli or Yeast His 265
Rat AQP5-395R Recombinant Rat AQP5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AQP5-395R-B Recombinant Rat AQP5 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL-19211HF Recombinant Full Length Human Aquaporin-5(Aqp5) Protein, His-Tagged E.coli expression system His Full Length (1-265aa)
Milnesium tardigradum (Water bear) (Tardigrade) RFL29582MF Recombinant Full Length Milnesium Tardigradum Aquaporin-5(Aqp5) Protein, Tag-Free E.coli expression system Tag-Free Full Length (1-277)
Mus musculus (Mouse) RFL11564MF Recombinant Full Length Mouse Aquaporin-5(Aqp5) Protein, His-Tagged E.coli expression system His Full Length (1-265)
Ovis aries (Sheep) RFL34575OF Recombinant Full Length Sheep Aquaporin-5(Aqp5) Protein, His-Tagged E.coli expression system His Full Length (1-265)
Rattus norvegicus (Rat) RFL-9581RF Recombinant Full Length Rat Aquaporin-5(Aqp5) Protein, His-Tagged E.coli expression system His Full Length (1-265)
Sus scrofa (Pig) RFL-32166SF Recombinant Full Length Pig Aquaporin-5(Aqp5) Protein, His-Tagged E.coli expression system His Full Length (1-265)
Pig AQP5-3602P Recombinant Pig AQP5, His-tagged E.Coli or Yeast His 265
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AQP5 Related Articles

AQP5 involved in several pathways and played different roles in them. We selected most pathways AQP5 participated on our site, such as Salivary secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with AQP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Salivary secretionPRKACG;MUC5B;PMAP-36;CALM1;CST1;CALM4;ATP1A1;PLCB4;ATP1B1

AQP5 has several biochemical functions, for example, glycerol channel activity, protein binding, water channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AQP5 itself. We selected most functions AQP5 had, and list some proteins which have the same functions with AQP5. You can find most of the proteins on our site.

Function Related Protein
glycerol channel activityAQP3B;AQP6;MIPA;AQP5;AQP8;AQP1;AQP10B;AQP9B;AQP7
protein bindingUSP49;CLDN8;ACE;THOC7;Cd79a, Cd79b;MED9;URM1;MAST2;UBAC1
water channel activityMIP;AQP1A.1;AQP5;AQP7;AQP10A;AQP8A.1;AQP2;AQP1A.2;AQP3

AQP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AQP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of AQP5.

MDFI; KRT31; KRT40; HNRPK; NOTCH2NL; CREB3; WNT2; GLRX

Tsai, MC; Lin, HJ; et al. High-altitude pulmonary edema can be prevented by heat shock protein 70-mediated hyperbaric oxygen preconditioning. JOURNAL OF TRAUMA AND ACUTE CARE SURGERY 77:585-591(2014).
Tran, TL; Bek, T; et al. Altered aquaporin expression in glaucoma eyes. APMIS 122:772-780(2014).
  • Q&As
  • Reviews

Q&As (26)

Ask a question
Are there any factors that can modulate the expression of AQP5 in the lungs? 12/26/2022

Yes, various factors can influence the expression of AQP5 in the lungs. For example, growth factors like epidermal growth factor (EGF) and transforming growth factor-beta (TGF-beta) can stimulate AQP5 expression, while inflammatory mediators such as interferons and tumor necrosis factor alpha (TNF-alpha) can downregulate its expression.

Are there any factors that can modulate the expression of AQP5 in the lungs? 12/26/2022

Yes, various factors can influence the expression of AQP5 in the lungs. For example, growth factors like epidermal growth factor (EGF) and transforming growth factor-beta (TGF-beta) can stimulate AQP5 expression, while inflammatory mediators such as interferons and tumor necrosis factor alpha (TNF-alpha) can downregulate its expression.

How is the structure of AQP5 protein determined? 04/24/2022

The structure of AQP5 has been determined using techniques such as X-ray crystallography and cryo-electron microscopy. These methods provide detailed information about the arrangement of atoms and help understand how the protein functions as a water channel.

Is AQP5 involved in any diseases or conditions? 04/04/2022

Yes, alterations in AQP5 expression or function have been associated with various diseases. For example, reduced levels of AQP5 have been observed in patients with Sjögren's syndrome, an autoimmune disorder that affects exocrine glands and causes dry mouth and dry eyes. AQP5 dysfunction has also been implicated in the development of respiratory disorders, including asthma and chronic obstructive pulmonary disease (COPD).

Can modulation of AQP5 expression or activity have any potential therapeutic benefits? 01/11/2022

The modulation of AQP5 expression or activity has the potential for therapeutic benefits in various conditions. For example, in dry eye disease, increasing AQP5 expression or function in the lacrimal glands may help enhance tear production and alleviate symptoms. Similarly, targeting AQP5 in respiratory disorders or other fluid imbalance-related conditions could potentially improve lung function or restore fluid balance. However, more research is needed to fully understand the therapeutic potential and safety of such interventions.

Can modulation of AQP5 expression or activity have any potential therapeutic benefits? 01/11/2022

The modulation of AQP5 expression or activity has the potential for therapeutic benefits in various conditions. For example, in dry eye disease, increasing AQP5 expression or function in the lacrimal glands may help enhance tear production and alleviate symptoms. Similarly, targeting AQP5 in respiratory disorders or other fluid imbalance-related conditions could potentially improve lung function or restore fluid balance. However, more research is needed to fully understand the therapeutic potential and safety of such interventions.

Are there any AQP5 mutations associated with human diseases? 08/29/2021

Yes, mutations in the AQP5 gene have been associated with certain human diseases. For instance, a mutation in the AQP5 gene has been linked to autosomal dominant diffuse non-epidermolytic palmoplantar keratoderma (AD-palmoplantar keratoderma), which is a skin disorder characterized by thickened skin on the palms and soles. Additionally, alterations in AQP5 expression or function have been implicated in conditions such as Sjögren's syndrome and chronic obstructive pulmonary disease (COPD).

Are there any AQP5 mutations associated with human diseases? 08/29/2021

Yes, mutations in the AQP5 gene have been associated with certain human diseases. For instance, a mutation in the AQP5 gene has been linked to autosomal dominant diffuse non-epidermolytic palmoplantar keratoderma (AD-palmoplantar keratoderma), which is a skin disorder characterized by thickened skin on the palms and soles. Additionally, alterations in AQP5 expression or function have been implicated in conditions such as Sjögren's syndrome and chronic obstructive pulmonary disease (COPD).

Are there any mutations in the AQP5 gene associated with disease? 10/17/2020

Yes, mutations in the AQP5 gene have been identified in some individuals with conditions like X-linked cataracts, which cause opacity in the lens of the eye, and nephrogenic diabetes insipidus, a disorder characterized by excessive thirst and urination.

Are there any ongoing research efforts related to AQP5? 11/04/2019

Yes, ongoing research aims to better understand the role of AQP5 in various diseases and conditions, including respiratory disorders. Scientists are investigating ways to modulate its function pharmacologically, which may lead to the development of new treatment options for related conditions.

How is AQP5 involved in the secretion of saliva and tears? 01/26/2019

AQP5 is crucial for the secretion of saliva and tears. It is highly expressed in the acinar cells of salivary and lacrimal glands, where it facilitates the movement of water across the cell membranes. This allows for the production and secretion of saliva and tears, helping to maintain oral and ocular moisture.

How is AQP5 involved in the secretion of saliva and tears? 01/26/2019

AQP5 is crucial for the secretion of saliva and tears. It is highly expressed in the acinar cells of salivary and lacrimal glands, where it facilitates the movement of water across the cell membranes. This allows for the production and secretion of saliva and tears, helping to maintain oral and ocular moisture.

Are there any current drugs or therapies that target AQP5? 05/07/2018

Currently, there are no approved drugs or therapies specifically targeting AQP5. However, there is ongoing research exploring the development of compounds that can modulate AQP5 expression or function. Some studies have shown promising results with experimental drugs in preclinical models of conditions such as dry eye disease and respiratory disorders. Nevertheless, further research and clinical trials are needed before any targeted AQP5 therapies can be widely used in clinical practice.

Are there any current drugs or therapies that target AQP5? 05/07/2018

Currently, there are no approved drugs or therapies specifically targeting AQP5. However, there is ongoing research exploring the development of compounds that can modulate AQP5 expression or function. Some studies have shown promising results with experimental drugs in preclinical models of conditions such as dry eye disease and respiratory disorders. Nevertheless, further research and clinical trials are needed before any targeted AQP5 therapies can be widely used in clinical practice.

Is AQP5 expression regulated by any hormones? 03/28/2018

Yes, AQP5 expression can be regulated by hormones. For example, studies have shown that the hormone estrogen can upregulate AQP5 expression in the lacrimal glands and salivary glands. Additionally, thyroid hormones have also been found to influence AQP5 expression in the lungs and other tissues.

Is AQP5 expression regulated by any hormones? 03/28/2018

Yes, AQP5 expression can be regulated by hormones. For example, studies have shown that the hormone estrogen can upregulate AQP5 expression in the lacrimal glands and salivary glands. Additionally, thyroid hormones have also been found to influence AQP5 expression in the lungs and other tissues.

Are there any drugs or compounds that specifically target AQP5? 03/15/2018

Currently, there are no approved drugs that specifically target AQP5. However, ongoing research aims to identify and develop compounds that can modulate AQP5 activity, which may have potential therapeutic applications in diseases where abnormal fluid transport occurs.

How is the expression of AQP5 regulated? 07/17/2017

The expression of AQP5 can be regulated by various factors, including hormones, growth factors, and cellular signaling pathways. For example, the production of saliva and tears can stimulate AQP5 expression, while certain disease conditions or medications can decrease its expression.

Can AQP5 be a potential target for therapeutic interventions? 05/06/2017

Yes, given its involvement in various diseases, AQP5 is being explored as a potential therapeutic target. Modulating AQP5 function could potentially help manage conditions related to fluid secretion and absorption, such as dry mouth and dry eye symptoms in Sjögren's syndrome.

Can AQP5 be targeted for therapeutic interventions in conditions related to fluid imbalance? 05/01/2017

Targeting AQP5 for therapeutic interventions is an area of active research. Modulating its expression, activity, or regulation may have potential applications in conditions related to fluid imbalance, such as dry eye disease, Sjögren's syndrome, and certain respiratory disorders. However, further studies are needed to fully understand the implications and develop targeted therapies.

Can AQP5 be targeted for therapeutic interventions in conditions related to fluid imbalance? 05/01/2017

Targeting AQP5 for therapeutic interventions is an area of active research. Modulating its expression, activity, or regulation may have potential applications in conditions related to fluid imbalance, such as dry eye disease, Sjögren's syndrome, and certain respiratory disorders. However, further studies are needed to fully understand the implications and develop targeted therapies.

Is there any connection between AQP5 and dry eye disease? 03/04/2017

Yes, there is a connection between AQP5 and dry eye disease. Dry eye disease is characterized by a reduction in tear production and/or increased tear evaporation, leading to ocular dryness and discomfort. Studies have shown that decreased expression or dysfunction of AQP5 in the lacrimal glands can contribute to the development of dry eye disease.

Is there any connection between AQP5 and dry eye disease? 03/04/2017

Yes, there is a connection between AQP5 and dry eye disease. Dry eye disease is characterized by a reduction in tear production and/or increased tear evaporation, leading to ocular dryness and discomfort. Studies have shown that decreased expression or dysfunction of AQP5 in the lacrimal glands can contribute to the development of dry eye disease.

Does AQP5 have any other functions besides water transport? 01/22/2017

Besides its role as a water channel, AQP5 has been suggested to have additional functions. It has been implicated in cell migration and tissue inflammation, although the precise mechanisms are still being investigated. Further research is needed to fully understand these additional functions of AQP5.

Does AQP5 have any other functions besides water transport? 01/22/2017

Besides its role as a water channel, AQP5 has been suggested to have additional functions. It has been implicated in cell migration and tissue inflammation, although the precise mechanisms are still being investigated. Further research is needed to fully understand these additional functions of AQP5.

Can AQP5 be used as a biomarker in certain diseases? 12/20/2016

Yes, the altered expression or function of AQP5 has been suggested as a potential biomarker in certain diseases. For instance, decreased levels of AQP5 in saliva samples may serve as a biomarker for Sjögren's syndrome, aiding in its diagnosis.

Customer Reviews (8)

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Reviews
05/24/2022

    In addition to their expertise, the manufacturer's technical support team can assist in troubleshooting and optimizing the handling and application of the AQP5 protein.

    06/07/2020

      the AQP5 protein's high quality and its compatibility with my experimental needs, coupled with the manufacturer's excellent technical support, create a valuable alliance that contributes to successful research endeavors.

      05/23/2020

        This level of support ensures that researchers have a seamless experience, enabling them to focus on their research goals without worrying about logistical or technical concerns.

        05/11/2020

          researchers highly appreciate AQP5 protein for its excellent performance in ELISA assays and protein electron microscopy structure analysis.

          12/12/2019

            The manufacturer's commitment to providing high-quality proteins is evident in their meticulous production process, ensuring the purity and reliability of the ARAE protein.

            04/01/2019

              They offer comprehensive technical support, including responsive customer service, availability of product information, and timely delivery of the product.

              09/16/2017

                AQP5 protein offers numerous advantages in trials, ranging from its stability and bioactivity to the manufacturer's commitment to customer support.

                12/05/2016

                  The AQP5 protein is characterized by its exceptional quality, making it an ideal choice to fulfill my experimental requirements.

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