aldh4a1
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  • Official Full Name
  • aldehyde dehydrogenase 4 family, member A1
  • Background
  • This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
  • Synonyms
  • ALDH4A1; aldehyde dehydrogenase 4 family, member A1; ALDH4; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; P5CDh; P5C dehydrogenase; aldehyde dehydrogenase family 4 member A1; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase; P5C
Cat.#:ALDH4A1-449HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALDH4A1 Protein, GST-tagged
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Cat.#:ALDH4A1-472HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ALDH4A1 Protein, His & GST-tagged
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Cat.#:ALDH4A1-499HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aldehyde Dehydrogenase 4 Family, Member A1, GST-tagged
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Cat.#:ALDH4A1-516HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ALDH4A1, Gly & Pro tagged
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Cat.#:ALDH4A1-1530MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALDH4A1 Protein
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Cat.#:ALDH4A1-4544CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ALDH4A1
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Cat.#:ALDH4A1-11377ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ALDH4A1
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Cat.#:ALDH4A1-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ALDH4A1 cell lysate
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Cat.#:ALDH4A1-434HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ALDH4A1 cell lysate
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Involved Pathway

ALDH4A1 involved in several pathways and played different roles in them. We selected most pathways ALDH4A1 participated on our site, such as Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH4A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alanine, aspartate and glutamate metabolism
ALDH4A1; GPT2L; ASL2; ASPA; GLSA; AGXTA; GAD1; ASS1; GLUD1A; GOT2
Arginine and proline metabolism
AMD1; L3HYPDH; CKMT2; MAOA; ADC; OAT; P4HA2; ABP1; SAT2; ALDH9A1A.1
Metabolic pathways
COQ3; SGPL1; IPMKB; MTMR4; AGPHD1; ALDOA; ATP6V1G1; FUT7; ALDOCA; GALNTL1

Protein Function

ALDH4A1 has several biochemical functions, for example, 1-pyrroline-5-carboxylate dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH4A1 itself. We selected most functions ALDH4A1 had, and list some proteins which have the same functions with ALDH4A1. You can find most of the proteins on our site.
Function
Related Protein
Function 1-pyrroline-5-carboxylate dehydrogenase activity
Related Protein ALDH4A1
Function aldehyde dehydrogenase (NAD) activity
Related Protein ALDH3A2; ALDH4A1; ALDH1L1; ALDH16A1; ALDH1A1; ALDH9A1B; ALDH2; ALDH8A1; ALDH3A2B; ALDH5A1
Function electron carrier activity
Related Protein COX7A3; NDUFA12; CYP1A2; GPX2; AOX4; ALDH4A1; TXNRD3; AKR7A2; CYCSB; NDUFS1
Function identical protein binding
Related Protein MAP3K13; RAF1; THBS1; BCL2; CLDN4; POU3F2; NCL; GRASP; GOT2; ECI1

Interacting Protein

ALDH4A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH4A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH4A1.
ARG1; CLPP

ALDH4A1 Related Articles

Wang, L; Guo, HJ; et al. Enrichment and characterization of cancer stem-like cells from a cervical cancer cell line. MOLECULAR MEDICINE REPORTS 9:2117-2123(2014).
Ueyama, T; Yamamoto, Y; et al. Is Gastrectomy-Induced High Turnover of Bone with Hyperosteoidosis and Increase of Mineralization a Typical Osteomalacia?. PLOS ONE 8:-(2013).