Recombinant Human ALDH4A1 Protein, GST-tagged

• Cat.No.: ALDH4A1-449H
• Product Overview: Human ALDH4A1 full-length ORF ( AAH07581, 1 a.a. - 563 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2009]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 87.67 kDa
• AA Sequence: MLLPAPALRRALLSRPWTGAGLRWK HTSSLKVANEPVLAFTQGSPERDAL QKALKDLKGRMEAIPCVVGDEEVWT SDVQYQVSPFNHGHKVAKFCYADKS LLNKAIEAALAARKEWDLKPIADRA QIFLKAADMLSGPRRAEILAKTMVG QGKTVIQAEIDAAAELIDFFRFNAK YAVELEGQQPISVPPSTNSTVYRGL EGFVAAISPFNFTAIGGNLAGAPAL MGNVVLWKPSDTAMLASYAVYRILR EAGLPPNIIQFVPADGPLFGDTVTS SEHLCGINFTGSVPTFKHLWKQVAQ NLDRFHTFPRLAGECGGKNFHFVHR SADVESVVSGTLRSAFEYGGQKCSA CSRLYVPHSLWPQIKGRLLEEHSRI KVGDPAEDFGTFFSAVIDAKSFARI KKWLEHARSSPSLTILAGGKCDDSV GYFVEPCIVESKDPQEPIMKEEIFG PVLSVYVYPDDKYKETLQLIDSTTS YGLTGAVFSQDKDVVQEATKVLRNA AGNFYINDKSTGSIVGQQPFGGARA SGTNDKPGGPHYILRWTSPQVIKET HKPLGDWSYAYMQ
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ALDH4A1 aldehyde dehydrogenase 4 family, member A1 [ Homo sapiens ]
• Official Symbol: ALDH4A1
• Synonyms: ALDH4A1; aldehyde dehydrogenase 4 family, member A1; ALDH4; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; P5CDh; P5C dehydrogenase; aldehyde dehydrogenase family 4 member A1; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase; P5CD; DKFZp779M035
• Gene ID: 8659
• mRNA Refseq: NM_001161504
• Protein Refseq: NP_001154976
• MIM: 606811
• UniProt ID: P30038