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CLCN1

  • Official Full Name

    chloride channel 1

  • Overview

    The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which;demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded;by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two;forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia;(Thomsen). Alternative splicing results in multiple transcript variants.
  • Synonyms

    CLCN1; chloride channel 1; chloride channel protein 1; Chloride channel protein skeletal muscle; skeletal muscle; Chloride channel protein; CIC 1; CIC1; ClC-1; CLC1; CLCN1_HUMAN; MGC138361; MGC142055; OTTMUSP00000052750; OTTMUSP00000052753; OTTMUSP00000052757; arrested development of righting response; chloride channel protein, skeletal muscle; adr; mto; SMCC1; nmf355; myotonia;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLCN1-1414H Recombinant Human CLCN1 Protein, GST-tagged Wheat Germ GST
Human CLCN1-1965HF Recombinant Full Length Human CLCN1 Protein, GST-tagged In Vitro Cell Free System GST 988 amino acids
Human CLCN1-01HCL Recombinant Human CLCN1 cell lysate, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CLCN1-3512M Recombinant Mouse CLCN1 Protein Mammalian Cell His
Mouse CLCN1-1717M Recombinant Mouse CLCN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CLCN1-1717M-B Recombinant Mouse CLCN1 Protein Pre-coupled Magnetic Beads HEK293
Rat CLCN1-1424R Recombinant Rat CLCN1 Protein Mammalian Cell His
Rat CLCN1-1082R Recombinant Rat CLCN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CLCN1-1082R-B Recombinant Rat CLCN1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CLCN1 involved in several pathways and played different roles in them. We selected most pathways CLCN1 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ion channel transportATP7B;FXYD6;CLCA1;TTYH2;TRPC4AP;BEST1;Ano3;TRPC4APB;TRPM1B
Stimuli-sensing channelsTTYH2;CLCN7;CLCA1;TRPC5;ANO9;ANO6;CLCN2;ANO7;ANO4
Transmembrane transport of small moleculesCLCN1A;SLC39A8;SLCO3A1;OSTM1;SLC9A6B;FTH1B;MCOLN3;ABCA8;SLC22A7B.1

CLCN1 has several biochemical functions, for example, chloride channel activity, protein binding, voltage-gated chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCN1 itself. We selected most functions CLCN1 had, and list some proteins which have the same functions with CLCN1. You can find most of the proteins on our site.

Function Related Protein
chloride channel activitySLC26A3.2;SLC26A1;CLCNKB;CLIC4;APOL1;GABRE;SLC26A6L;TTYH2;CLIC3
protein bindingPQBP1;NOSIP;RPL10A;RPL14;HIST1H4G;NHLRC2;SYNDIG1;HLA-DOA;OCIAD1
voltage-gated chloride channel activityCLCNKB;CLCN5;CLCN1A;CLCN3;CLCNKA;CLCN2;ANO6;CLCN1;CLCN6

CLCN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCN1.

FAM9B; APPBP2

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