clcn1
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  • Official Full Name
  • chloride channel 1
  • Background
  • The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which;demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded;by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two;forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia;(Thomsen). Alternative splicing results in multiple transcript variants.
  • Synonyms
  • CLCN1; chloride channel 1; chloride channel protein 1; Chloride channel protein skeletal muscle; skeletal muscle; Chloride channel protein; CIC 1; CIC1; ClC-1; CLC1; CLCN1_HUMAN; MGC138361; MGC142055; OTTMUSP00000052750; OTTMUSP00000052753; OTTMUSP00000052757; arrested development of righting response; chloride channel protein, skeletal muscle; adr; mto; SMCC1; nmf355; myotonia
Cat.#:CLCN1-1414HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLCN1 Protein, GST-tagged
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Cat.#:CLCN1-3512MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CLCN1 Protein
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Cat.#:CLCN1-1424RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CLCN1 Protein
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Involved Pathway

CLCN1 involved in several pathways and played different roles in them. We selected most pathways CLCN1 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ion channel transport
UNC79; CLCN7; WNK1; TRDN; GLRBA; CLCNKA; TRPC4APA; ANO5B; CLCN5; FXYD3
Stimuli-sensing channels
TRPA1B; CLCNK; SLC9A10; BEST1; SLC17A3; TRPM1B; CLCN5; TRDN; TRPC4AP; CLCN1
Transmembrane transport of small molecules
SLC22A17; SLC2A10; TRPC4APA; ANO10; ADD3A; RHCG; TFR1B; FXYD6-FXYD2; SLC6A18; SLC3A2B

Protein Function

CLCN1 has several biochemical functions, for example, chloride channel activity, protein binding, voltage-gated chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCN1 itself. We selected most functions CLCN1 had, and list some proteins which have the same functions with CLCN1. You can find most of the proteins on our site.
Function
Related Protein
Function chloride channel activity
Related Protein CLCN7; CLIC5A; GABRA2; SLC26A2; GABRB2; CLCNKB; TTYH2; TTYH3; GABRA6A; CLCN4
Function protein binding
Related Protein LMO1; PPP2R2C; LRP6; ZSCAN1; MYOZ2; FAM164A; PER3; CDK5R1; MATN2; NLGN4X
Function voltage-gated chloride channel activity
Related Protein CLCNK; CLCN4-2; CLCN1A; CLCN5; CLCN4; CLCN7; CLCN1; CLCNKB; ANO6; CLCN6

Interacting Protein

CLCN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCN1.
FAM9B; APPBP2