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CLCN6

  • Official Full Name

    chloride channel 6

  • Overview

    The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.
  • Synonyms

    CLCN6; chloride channel 6; chloride transport protein 6; ClC 6; KIAA0046; ClC6; OTTHUMP00000002410; OTTHUMP00000002411; OTTHUMP00000002412; OTTHUMP00000002413; OTTHUMP00000002414; chloride channel protein 6; CLC-6;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLCN6-1420H Recombinant Human CLCN6 Protein, GST-tagged Wheat Germ GST
Human CLCN6-1996HF Recombinant Full Length Human CLCN6 Protein, GST-tagged In Vitro Cell Free System GST 869 amino acids
Mouse CLCN6-3517M Recombinant Mouse CLCN6 Protein Mammalian Cell His
Mouse CLCN6-1721M Recombinant Mouse CLCN6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CLCN6-1721M-B Recombinant Mouse CLCN6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CLCN6-889R Recombinant Rhesus monkey CLCN6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CLCN6-715R-B Recombinant Rhesus Macaque CLCN6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CLCN6-715R Recombinant Rhesus Macaque CLCN6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CLCN6-5472C Recombinant Chicken CLCN6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CLCN6 Related Articles

CLCN6 involved in several pathways and played different roles in them. We selected most pathways CLCN6 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCN6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ion channel transportATP7B;GLRBA;CLCN1A;CLCA1;TRPM1A;TCIRG1;ATP1A1A.3;ASPH;TRPM1B
Stimuli-sensing channelsANO9;SRI;WNK2;TRPM1B;TPCN1;ANO1;TTYH2;TRPM1A;ANO10A
Transmembrane transport of small moleculesSLC9A5;ANKHA;SLC3A2A;MAGT1;SLC29A1A;SLC1A4;TPCN1;AZGP1;SLC12A3

CLCN6 has several biochemical functions, for example, ATP binding, antiporter activity, ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCN6 itself. We selected most functions CLCN6 had, and list some proteins which have the same functions with CLCN6. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNTRK2;ATP9B;CAMK1GB;TARSL2;DDX18;RFC4;TNNI3K;PRKD3;PTK2
antiporter activitySLC35E1;Slc4a2;SLC7A10;SLC9A9;SLC47A2;SLC9A3.1;SLC35E4;CLCN3;SLC35E3
ion channel activityGRIK3;TRPC4B;TRPC5A;KCNC3B;KCNV2B;TRPC2;P2RX4B;AKR1C1;TPC3
nucleotide bindingTNRC6B;CPEB3;CLCN3;TTLL2;RHOGB;EIF4B;SMYHC1;PAK2A;HSPA4B
voltage-gated chloride channel activityCLCNK;CLCN2;CLCN4-2;CLCNKA;CLCN7;CLCN6;CLCN5;CLCN1A;CLCN1

CLCN6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCN6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCN6.

Ywhae

Ohshiro, J; Yamamura, H; et al. The multiple expression of Ca2+-activated Cl- channels via homo- and hetero-dimer formation of TMEM16A splicing variants in murine portal vein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 443:518-523(2014).
Wahl, V; Vogler, S; et al. OSTEOPONTIN INHIBITS OSMOTIC SWELLING OF RETINAL GLIAL (MULLER) CELLS BY INDUCING RELEASE OF VEGF. NEUROSCIENCE 246:59-72(2013).
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