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GRM7

  • Official Full Name

    glutamate receptor, metabotropic 7

  • Overview

    L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    GRM7; glutamate receptor, metabotropic 7; metabotropic glutamate receptor 7; GLUR7; GPRC1G; mGlu7; MGLUR7; FLJ40498; Glutamate receptor metabotropic 7; GRM7_HUMAN; OTTHUMP00000206961; OTTHUMP00000214674; OTTHUMP00000214675; OTTHUMP00000155219; OTTHUMP00000206960; OTTHUMP00000238688;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRM7-5732HCL Recombinant Human GRM7 293 Cell Lysate HEK293 N/A
Human GRM7-1144HFL Recombinant Human GRM7 protein, His&Flag-tagged HEK293 His&Flag 1-915 aa
Human GRM7-028H Active Recombinant Human GRM7 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human GRM7-5596HF Recombinant Full Length Human GRM7 Protein, GST-tagged In Vitro Cell Free System GST 915 amino acids
Human GRM7-5370H Recombinant Human GRM7 Protein Wheat Germ N/A
Human GRM7-5371H Recombinant Human GRM7 Protein, GST-tagged Wheat Germ GST
Human GRM7-5593HF Recombinant Full Length Human GRM7 Protein In Vitro Cell Free System 613 amino acids
Mouse GRM7-7290M Recombinant Mouse GRM7 Protein Mammalian Cell His
Mouse GRM7-3943M Recombinant Mouse GRM7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GRM7-3943M-B Recombinant Mouse GRM7 Protein Pre-coupled Magnetic Beads HEK293
Rat GRM7-2718R Recombinant Rat GRM7 Protein Mammalian Cell His
Rat GRM7-2372R-B Recombinant Rat GRM7 Protein Pre-coupled Magnetic Beads HEK293
Rat GRM7-2372R Recombinant Rat GRM7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish GRM7-8399Z Recombinant Zebrafish GRM7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GRM7 Related Articles

GRM7 involved in several pathways and played different roles in them. We selected most pathways GRM7 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Phospholipase D signaling pathwayMAP2K1;F2R;GRB2;SHC2;PDGFB;GNAS;PRKCA;PIK3CD;HRAS
Neuroactive ligand-receptor interactionP2RX6;P2RX7;ADORA1;GRM8B;GHRA;GABRA4;CHRM5A;PTGER1A;GRIA2B
Glutamatergic synapseGRIN1;PRKCG;MAPK3;GRM5;PLA2G4D;DLGAP1;MAPK1;GNG13;SHANK2

GRM7 has several biochemical functions, for example, PDZ domain binding, adenylate cyclase inhibitor activity, calcium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM7 itself. We selected most functions GRM7 had, and list some proteins which have the same functions with GRM7. You can find most of the proteins on our site.

Function Related Protein
PDZ domain bindingLIN7C;SNTA1;ATP2B3A;ADAM17;LLGL2;LPAR1;DLC;GRIK2;FZD7
adenylate cyclase inhibitor activity
calcium channel regulator activityGNB2;CRISP1;SGK2B;CACNA2D1A;TSPAN13B;NRXN3;CAV3;GRM7;PRKCB
calcium ion bindingEFCAB4A;SYTL1;PCLO;HPCAL4;PCDH1G1;COL4A3BPA;NECAB3;PCDH2AA15;EGFL8
glutamate bindingSLC1A3;GRM7;CPS1;GRIN2A;GCLC;GAD2;GRIK1;GRIN1;SLC1A1
glutamate receptor activityGRM5;GRIA1;GRM2;GRM3;GRID2;GRIK3;GRM8;GRM1;GRM7
group III metabotropic glutamate receptor activityGRM6A;GRM7;GRM4;GRM6B;GRM8;GRM6
serine bindingSHMT1;GRM7;THNSL2
voltage-gated calcium channel activityIL1RAPL1;CACNG6;CACNB4B;CACNG2B;CACNA2D1;CATSPER1;NCS1;CACNG3;PKD2

GRM7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM7 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM7.

Spampinato, SF; Merlo, S; et al. Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes. FRONTIERS IN CELLULAR NEUROSCIENCE 8:-(2015).
Ullmer, C; Zoffmann, S; et al. Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7. BRITISH JOURNAL OF PHARMACOLOGY 167:1448-1466(2012).
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