Recombinant Human GRM7 Protein

• Cat.No.: GRM7-5370H
• Product Overview: Human GRM7 full-length ORF (NP_000835.1) recombinant protein without tag.

Specification

• Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Form: Liquid
• Molecular Mass: 102.3 kDa
• AA Sequence: MVQLRKLLRVLTLMKFPCCVLEVLL CALAAAARGQEMYAPHSIRIEGDVT LGGLFPVHAKGPSGVPCGDIKRENG IHRLEAMLYALDQINSDPNLLPNVT LGARILDTCSRDTYALEQSLTFVQA LIQKDTSDVRCTNGEPPVFVKPEKV VGVIGASGSSVSIMVANILRLFQIP QISYASTAPELSDDRRYDFFSRVVP PDSFQAQAMVDIVKALGWNYVSTLA SEGSYGEKGVESFTQISKEAGGLCI AQSVRIPQERKDRTIDFDRIIKQLL DTPNSRAVVIFANDEDIKQILAAAK RADQVGHFLWVGSDSWGSKINPLHQ HEDIAEGAITIQPKRATVEGFDAYF TSRTLENNRRNVWFAEYWEENFNCK LTISGSKKEDTDRKCTGQERIGKDS NYEQEGKVQFVIDAVYAMAHALHHM NKDLCADYRGVCPEMEQAGGKKLLK YIRNVNFNGSAGTPVMFNKNGDAPG RYDIFQYQTTNTSNPGYRLIGQWTD ELQLNIEDMQWGKGVREIPASVCTL PCKPGQRKKTQKGTPCCWTCEPCDG YQYQFDEMTCQHCPYDQRPNENRTG CQDIPIIKLEWHSPWAVIPVFLAML GIIATIFVMATFIRYNDTPIVRASG RELSYVLLTGIFLCYIITFLMIAKP DVAVCSFRRVFLGLGMCISYAALLT KTNRIYRIFEQGKKSVTAPRLISPT SQLAITSSLISVQLLGVFIWFGVDP PNIIIDYDEHKTMNPEQARGVLKCD ITDLQIICSLGYSILLMVTCTVYAI KTRGVPENFNEAKPIGFTMYTTCIV WLAFIPIFFGTAQSAEKLYIQTTTL TISMNLSASVALGMLYMPKVYIIIF HPELNVQKRKRSFKAVVTAATMSSR LSHKPSDRPNGEAKTELCENVDPNS PAAKKKYVSYNNLVI
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Usage: Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: GRM7 glutamate receptor, metabotropic 7 [ Homo sapiens ]
• Official Symbol: GRM7
• Synonyms: GRM7; glutamate receptor, metabotropic 7; metabotropic glutamate receptor 7; GLUR7; GPRC1G; mGlu7; MGLUR7; MGLU7; FLJ40498
• Gene ID: 2917
• mRNA Refseq: NM_000844
• Protein Refseq: NP_000835
• MIM: 604101
• UniProt ID: Q14831