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HCLS1

  • Official Full Name

    hematopoietic cell-specific Lyn substrate 1

  • Overview

    HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin. HS1 contains four cortactin repeats and a single SH3 domain. This intracellular protein is phosphorylated following immune receptor
  • Synonyms

    HCLS1; hematopoietic cell-specific Lyn substrate 1; hematopoietic lineage cell-specific protein; cortactin like; CTTNL; HS1; p75; lckBP1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HCLS1-27309TH Recombinant Human HCLS1 Wheat Germ N/A 486 amino acids
Human HCLS1-4628H Recombinant Human HCLS1 Protein, GST-tagged Wheat Germ GST
Human HCLS1-27262TH Recombinant Human HCLS1 Wheat Germ N/A 90 amino acids
Human HCLS1-5611HCL Recombinant Human HCLS1 293 Cell Lysate HEK293 N/A
Human HCLS1-223HF Recombinant Full Length Human HCLS1 Protein In Vitro Cell Free System 486 amino acids
Human HCLS1-3512HF Recombinant Full Length Human HCLS1 Protein, GST-tagged In Vitro Cell Free System GST 486 amino acids
Human HCLS1-4139H Recombinant Human HCLS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HCLS1-1051H Recombinant Human HCLS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HCLS1-1979HFL Recombinant Full Length Human HCLS1 Protein, C-Flag-tagged Mammalian cells Flag
Human HCLS1-1051H-B Recombinant Human HCLS1 Protein Pre-coupled Magnetic Beads HEK293
Human HCLS1-3354H Recombinant Human HCLS1 Protein (Met1-Glu486), C-His tagged Mammalian cells C-His Met1-Glu486
Mouse HCLS1-7518M Recombinant Mouse HCLS1 Protein Mammalian Cell His
Mouse Hcls1-1101M Recombinant Mouse Hcls1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HCLS1-4081M-B Recombinant Mouse HCLS1 Protein Pre-coupled Magnetic Beads HEK293
Mouse HCLS1-4081M Recombinant Mouse HCLS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HCLS1-2050R Recombinant Rhesus monkey HCLS1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HCLS1-1871R-B Recombinant Rhesus Macaque HCLS1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HCLS1-1871R Recombinant Rhesus Macaque HCLS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HCLS1-4086Z Recombinant Zebrafish HCLS1 Mammalian Cell His
Chicken HCLS1-3052C Recombinant Chicken HCLS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HCLS1 involved in several pathways and played different roles in them. We selected most pathways HCLS1 participated on our site, such as Tight junction, Bacterial invasion of epithelial cells, Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCLS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Tight junctionNRAS;JAM2A;TJAP1;CLDN15LB;VMHC;PRKCQ;CLDN1;CASKA;PRKCBB
Bacterial invasion of epithelial cellsSHC3;FN1;PIK3CB;ELMO2;CTNNA1;CBLB;WASF2;WASF1;SEPT11
Pathogenic Escherichia coli infectionROCK1;ARPC5L;TUBB6;CD14;FYN;EZR;TUBB2A;TUBA3E;HCLS1
ShigellosisPFN1;MAPK8;IKBKG;ROCK2;MAD2L2;RELA;U2AF1;VCL;ROCK1
Proteoglycans in cancerWNT2;FASLG;WNT9A;ANK1;FZD3;MMP9;HPSE;PTPN6;WNT1

HCLS1 has several biochemical functions, for example, RNA polymerase II transcription factor binding, SH3 domain binding, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HCLS1 itself. We selected most functions HCLS1 had, and list some proteins which have the same functions with HCLS1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription factor bindingWWP2;XBP1;ZFPM2A;Ar;CREBBP;GATA2A;TEAD3;SPI1;KDM1A
SH3 domain bindingPLSCR4;TOM1L1;LANCL1;CYBA;INPP5J;CD3E;ELMO1;PLSCR1;QKI2
actin bindingDST;GCSAM;VMHCL;HIP1RB;VASP;HCLS1;DBNL;PLECA;WASL
protein bindingRSPO1;ASH2L;ETV5;CTAG1A;LIPT2;ZNF423;CNO;GIT2;LCMT2
protein complex bindingABI2;MLKL;RPAIN;DLG4;DAG1;AKAP5;PLK2;CD2AP;GNB1
protein kinase bindingFAM83A;USF1;NME2;CDC25A;CENPJ;CLTC;PEBP1;Cd24a;IBTK

HCLS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCLS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HCLS1.

SH2D4A; WIPF1; TERF1; LYN; Dlg4; Mbp; CASP3; WAS; SYK; cutA; ftsX; q8clc4_yerpe; q8czv1_yerpe; QKI

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