HCRT
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Official Full Name
hypocretin (orexin) neuropeptide precursor
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Overview
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. -
Synonyms
HCRT; hypocretin (orexin) neuropeptide precursor; orexin; OX; PPOX; Hcrt2; Hypocretin 2; hypocretin; NRCLP1; Orexin precursor; prepro orexin;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|GST
- N
- SUMO
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | HCRT-2983H | Recombinant Human HCRT Protein (Gln34-Met97), N-His tagged | E.coli | N-His | Gln34-Met97 | |
Human | HCRT-1168H | Recombinant Human HCRT Protein, His&SUMO-tagged | E.coli | N-His&SUMO | Gln34-Met97 | |
Mouse | HCRT-7522M | Recombinant Mouse HCRT Protein | Mammalian Cell | His | ||
Mouse | Hcrt-2651M | Recombinant Mouse Hcrt protein, His & GST-tagged | E.coli | His/GST | Gln33~Pro124 (Accession # O55241) | |
Mouse | HCRT-4084M-B | Recombinant Mouse HCRT Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | HCRT-4084M | Recombinant Mouse HCRT Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Hcrt-2652R | Recombinant Rat Hcrt protein, His & GST-tagged | E.coli | His/GST | Ala32~Ala123 (Accession # O55232) | |
Rat | HCRT-2810R | Recombinant Rat HCRT Protein | Mammalian Cell | His | ||
Rat | HCRT-2465R | Recombinant Rat HCRT Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | HCRT-2465R-B | Recombinant Rat HCRT Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | HCRT-2051R | Recombinant Rhesus monkey HCRT Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | HCRT-1872R | Recombinant Rhesus Macaque HCRT Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | HCRT-1872R-B | Recombinant Rhesus Macaque HCRT Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | HCRT-4723Z | Recombinant Zebrafish HCRT | Mammalian Cell | His | ||
Chicken | HCRT-5759C | Recombinant Chicken HCRT | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- HCRT Related Articles
- HCRT Related Research Area
HCRT involved in several pathways and played different roles in them. We selected most pathways HCRT participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCRT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Class A/1 (Rhodopsin-like receptors) | RLN3;CXCL11.8;LTB4R;PNOCB;RLN2;GPR120;ADRA2A;RHOL;EDN2 |
G alpha (q) signalling events | PMCH;TAC2;EDNRAB;LPAR1;GPR4;DGKB;NMBA;QRFPR;CCK |
GPCR downstream signaling | GPR132B;OXGR1A.1;NET1;CHRM4;NPB;TAS2R3;OPN4B;TRPC6A;KALRN |
GPCR ligand binding | UTS2D;FPR-RS3;PTHRP2;SSTR1;OPN1MW2;RAMP3;CASR;PYY;LPAR2B |
Gastrin-CREB signalling pathway via PKC and MAPK | GPR132;ANXA1C;PROKR2;DGKA;MGLL;NMBB;PROKR1;GPR68;RGS21 |
Orexin and neuropeptides FF and QRFP bind to their respective receptors | QRFP;QRFPR;HCRT;NPFFR2;NPFF |
Peptide ligand-binding receptors | NPFF;APLNR;PPY;EDN2;RLN2;PYY;UTS2;NMS;TAC2 |
Signal Transduction | NPS;EMR2;ARHGAP40;APLN;OR52J3;PPEF1;RPE65B;GPR77;RBCK1 |
HCRT has several biochemical functions, for example, neuropeptide hormone activity, type 1 hypocretin receptor binding, type 2 hypocretin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HCRT itself. We selected most functions HCRT had, and list some proteins which have the same functions with HCRT. You can find most of the proteins on our site.
Function | Related Protein |
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neuropeptide hormone activity | PENK;NTS;PYY;CALCB;NPPA;PPY;AGRP;CRH;C12orf39 |
type 1 hypocretin receptor binding | |
type 2 hypocretin receptor binding |
HCRT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCRT here. Most of them are supplied by our site. Hope this information will be useful for your research of HCRT.
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