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HCRT

  • Official Full Name

    hypocretin (orexin) neuropeptide precursor

  • Overview

    This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
  • Synonyms

    HCRT; hypocretin (orexin) neuropeptide precursor; orexin; OX; PPOX; Hcrt2; Hypocretin 2; hypocretin; NRCLP1; Orexin precursor; prepro orexin;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HCRT-2983H Recombinant Human HCRT Protein (Gln34-Met97), N-His tagged E.coli N-His Gln34-Met97
Human HCRT-1168H Recombinant Human HCRT Protein, His&SUMO-tagged E.coli N-His&SUMO Gln34-Met97
Mouse HCRT-7522M Recombinant Mouse HCRT Protein Mammalian Cell His
Mouse Hcrt-2651M Recombinant Mouse Hcrt protein, His & GST-tagged E.coli His/GST Gln33~Pro124 (Accession # O55241)
Mouse HCRT-4084M-B Recombinant Mouse HCRT Protein Pre-coupled Magnetic Beads HEK293
Mouse HCRT-4084M Recombinant Mouse HCRT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Hcrt-2652R Recombinant Rat Hcrt protein, His & GST-tagged E.coli His/GST Ala32~Ala123 (Accession # O55232)
Rat HCRT-2810R Recombinant Rat HCRT Protein Mammalian Cell His
Rat HCRT-2465R Recombinant Rat HCRT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HCRT-2465R-B Recombinant Rat HCRT Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HCRT-2051R Recombinant Rhesus monkey HCRT Protein, His-tagged Mammalian Cell His
Rhesus Macaque HCRT-1872R Recombinant Rhesus Macaque HCRT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HCRT-1872R-B Recombinant Rhesus Macaque HCRT Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HCRT-4723Z Recombinant Zebrafish HCRT Mammalian Cell His
Chicken HCRT-5759C Recombinant Chicken HCRT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HCRT Related Articles
  • HCRT Related Research Area

HCRT involved in several pathways and played different roles in them. We selected most pathways HCRT participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCRT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)RLN3;CXCL11.8;LTB4R;PNOCB;RLN2;GPR120;ADRA2A;RHOL;EDN2
G alpha (q) signalling eventsPMCH;TAC2;EDNRAB;LPAR1;GPR4;DGKB;NMBA;QRFPR;CCK
GPCR downstream signalingGPR132B;OXGR1A.1;NET1;CHRM4;NPB;TAS2R3;OPN4B;TRPC6A;KALRN
GPCR ligand bindingUTS2D;FPR-RS3;PTHRP2;SSTR1;OPN1MW2;RAMP3;CASR;PYY;LPAR2B
Gastrin-CREB signalling pathway via PKC and MAPKGPR132;ANXA1C;PROKR2;DGKA;MGLL;NMBB;PROKR1;GPR68;RGS21
Orexin and neuropeptides FF and QRFP bind to their respective receptorsQRFP;QRFPR;HCRT;NPFFR2;NPFF
Peptide ligand-binding receptorsNPFF;APLNR;PPY;EDN2;RLN2;PYY;UTS2;NMS;TAC2
Signal TransductionNPS;EMR2;ARHGAP40;APLN;OR52J3;PPEF1;RPE65B;GPR77;RBCK1

HCRT has several biochemical functions, for example, neuropeptide hormone activity, type 1 hypocretin receptor binding, type 2 hypocretin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HCRT itself. We selected most functions HCRT had, and list some proteins which have the same functions with HCRT. You can find most of the proteins on our site.

Function Related Protein
neuropeptide hormone activityPENK;NTS;PYY;CALCB;NPPA;PPY;AGRP;CRH;C12orf39
type 1 hypocretin receptor binding
type 2 hypocretin receptor binding

HCRT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCRT here. Most of them are supplied by our site. Hope this information will be useful for your research of HCRT.

Sato, H; Suzuki, Y; et al. HLA Class I Expression and Its Alteration by Preoperative Hyperthermo-Chemoradiotherapy in Patients with Rectal Cancer. PLOS ONE 9:-(2014).
Chen, XY; Li, R; et al. Identification of differentially expressed genes in hypothalamus of chicken during cold stress. MOLECULAR BIOLOGY REPORTS 41:2243-2248(2014).
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