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HERC5

  • Official Full Name

    hect domain and RLD 5

  • Overview

    This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
  • Synonyms

    HERC5; hect domain and RLD 5; E3 ISG15--protein ligase HERC5; CEB1; CEBP1; HECT domain and RCC1 like domain containing protein 5; Herc6; Cyclin E binding protein 1; Cyclin-E-binding protein 1; HECT domain and RCC1-like domain-containing protein 5; HECT E3 ubiquitin ligase; HERC5_HUMAN; cyclin-E binding protein 1; probable E3 ubiquitin-protein ligase HERC5;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HERC5-4693H Recombinant Human HERC5 Protein, GST-tagged Wheat Germ GST
Human HERC5-178H Recombinant Human HERC5, His-tagged E.coli His 681-1024aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HERC5 Related Articles

HERC5 involved in several pathways and played different roles in them. We selected most pathways HERC5 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, ISG15 antiviral mechanism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Antiviral mechanism by IFN-stimulated genesEIF4E3;USP18;KPNA4;NUP50;IFIT10;EIF4A2;EIF4G1;EIF4EB;IFIT12
Cytokine Signaling in Immune systemNUPL2;EIF4EB;PEA15;TRIM48;TAB1;IFIT3;SPNA1;CSK;PAQR3B
ISG15 antiviral mechanismEIF4G2;ARIH1;IFIT11;ARIH1L;KPNA3;EIF4E3;KPNA5;USP18;IFIT10
Immune SystemDEFB103A;DCTN6;S100B;ASB18;DYNC1I1;PANX1B;OSCAR;TRIM14;KIFAP3
Innate Immune SystemCASP2;IFI16;SIGIRR;SIGLEC14;POLR3G;POLR3C;NCKIPSD;MGC174155;TLR6
Interferon SignalingISG20;TRIM46;TRIM38;TRIM3;GBP4;GBP5;XAF1;EIF4E3;GBP1
Negative regulators of RIG-I/MDA5 signalingRNF216;TAX1BP1B;TAX1BP1;NLRC5;PCBP2;HERC5;RNF135;CYLD
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysTANK;TAX1BP1B;NLRC5;RNF135;TAX1BP1;PCBP2;RNF216;HERC5

HERC5 has several biochemical functions, for example, ISG15 transferase activity, ligase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC5 itself. We selected most functions HERC5 had, and list some proteins which have the same functions with HERC5. You can find most of the proteins on our site.

Function Related Protein
ISG15 transferase activityUBE2E2;HERC5;UBE2L6;UBE2E1
ligase activityHECW2;UBR3;BIRC7;NHLRC1;RBX1;COP1;TRIM28;RFWD3;DTX3L
poly(A) RNA bindingRRP9;CCDC137;RPS13;PCBP4;MTDH;SMG1;REPIN1;EIF4G2;RPN1
protein bindingSHD;HIST2H3C2;SCNN1G;OSBPL7;TRIM23;HOOK3;IL15RA;CD276;EXOSC7
ubiquitin protein ligase activitySIAH1;FBXO40;RFFL;HERC4;TRIM3;MED23;RNF7;RNF165;SYVN1

HERC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC5.

NUDCD2; UBE2E1; UBE2E3; UBE2E2; Srp72; RPL10; TTK; SNCA; HNRNPU; Mta1; GSG2; Rrbp1; Nrip3; AGO2

Huang, YF; Bulavin, DV; et al. Oncogene-mediated regulation of p53 ISGylation and functions. ONCOTARGET 5:5808-5818(2014).
Raterman, HG; Vosslamber, S; et al. The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients. ARTHRITIS RESEARCH & THERAPY 14:-(2012).
Malhotra, S; Bustamante, MF; et al. Search for Specific Biomarkers of IFN beta Bioactivity in Patients with Multiple Sclerosis. PLOS ONE 6:-(2011).
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