herc5
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  • Official Full Name
  • hect domain and RLD 5
  • Background
  • This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
  • Synonyms
  • HERC5; hect domain and RLD 5; E3 ISG15--protein ligase HERC5; CEB1; CEBP1; HECT domain and RCC1 like domain containing protein 5; Herc6; Cyclin E binding protein 1; Cyclin-E-binding protein 1; HECT domain and RCC1-like domain-containing protein 5; HECT E3 ubiquitin ligase; HERC5_HUMAN; cyclin-E binding protein 1; probable E3 ubiquitin-protein ligase HERC5
Cat.#:HERC5-4693HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HERC5 Protein, GST-tagged
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Cat.#:HERC5-178HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HERC5, His-tagged
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Involved Pathway

HERC5 involved in several pathways and played different roles in them. We selected most pathways HERC5 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, ISG15 antiviral mechanism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC5 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antiviral mechanism by IFN-stimulated genes
EIF4A1; IFIT14; IFIT8; EIF4E; JAK1; UBE2L6; EIF4A2; HERC5; EIF4G2A; ARIH1
Cytokine Signaling in Immune system
FGFR1B; KPNA5; TNIP2; SPTB; TAB1; PTPRA; KLB; EDAR; MX2; SPNA2
ISG15 antiviral mechanism
MX2; HERC5; KPNA4; ARIH1L; USP18; IFIT14; EIF4G2; UBE2L6; EIF4G2A; IFIT10
Immune System
CTSO; DEFA1; NLRP4E; EIF4G2; ABI2; DZIP3; CFHL1; IFITM3; KIF5B; UBE2U
Innate Immune System
DEFA1; DEFB116; PELI1; CR1; PANX1A; UNC93B1; MASP2; DEFA6; CYLD; ABI1A
Interferon Signaling
TRIM62; TRIM8; ARIH1L; TRIM26; SAMHD1; TRIM10; TRIM45; TRIM3; IFIT2; ARIH1
Negative regulators of RIG-I/MDA5 signaling
RNF216; CYLD; HERC5; TAX1BP1; RNF135; NLRC5; TAX1BP1B; PCBP2
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RNF216; RNF135; TAX1BP1B; TANK; NLRC5; TAX1BP1; PCBP2; HERC5

Protein Function

HERC5 has several biochemical functions, for example, ISG15 transferase activity, ligase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC5 itself. We selected most functions HERC5 had, and list some proteins which have the same functions with HERC5. You can find most of the proteins on our site.
Function
Related Protein
Function ISG15 transferase activity
Related Protein UBE2E2; UBE2L6; HERC5; UBE2E1
Function ligase activity
Related Protein TRAF6; PDZRN3; TRIM8; RANBP2; BRAP; RNF126; PIAS4; TTLL4; RNF34; LIPT2
Function poly(A) RNA binding
Related Protein GRN; SLBP; ZCCHC8; PTRF; EBNA1BP2; EIF3L; MRPL2; FCF1; CCDC47; HERC5
Function protein binding
Related Protein CD160; RAB5B; CCT8; TEAD2; THEM5; HRK; AP2A2; PSG5; CLK4; ENTPD3
Function ubiquitin protein ligase activity
Related Protein MED20; MSL2B; C18orf25; ASB4; CMTM2A; ITCHA; UBE2T; UBE2C; TRIM11; HERC4

Interacting Protein

HERC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC5.
NUDCD2; UBE2E1; UBE2E3; UBE2E2; Srp72; RPL10; TTK; SNCA; HNRNPU; Mta1; GSG2; Rrbp1; Nrip3; AGO2

HERC5 Related Articles

Huang, YF; Bulavin, DV; et al. Oncogene-mediated regulation of p53 ISGylation and functions. ONCOTARGET 5:5808-5818(2014).
Raterman, HG; Vosslamber, S; et al. The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients. ARTHRITIS RESEARCH & THERAPY 14:-(2012).
Malhotra, S; Bustamante, MF; et al. Search for Specific Biomarkers of IFN beta Bioactivity in Patients with Multiple Sclerosis. PLOS ONE 6:-(2011).