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HIF3A

  • Official Full Name

    hypoxia inducible factor 3, alpha subunit

  • Overview

    The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
  • Synonyms

    HIF3A; hypoxia inducible factor 3, alpha subunit; IPAS; MOP7; PASD7; HIF-3A; bHLHe17; hypoxia-inducible factor 3-alpha; HIF3-alpha-1; member of PAS protein 7; inhibitory PAS domain protein; PAS domain-containing protein 7; basic-helix-loop-helix-PAS protein MOP7; class E basic helix-loop-helix protein 17;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HIF3A-4749H Recombinant Human HIF3A Protein, GST-tagged Wheat Germ GST
Human HIF3A-5563HCL Recombinant Human HIF3A 293 Cell Lysate HEK293 N/A
Human HIF3A-3468HF Recombinant Full Length Human HIF3A Protein, GST-tagged In Vitro Cell Free System GST 363 amino acids
Rat HIF3A-2842R Recombinant Rat HIF3A Protein Mammalian Cell His
Rat HIF3A-2497R Recombinant Rat HIF3A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HIF3A-2497R-B Recombinant Rat HIF3A Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HIF3A Related Articles

HIF3A involved in several pathways and played different roles in them. We selected most pathways HIF3A participated on our site, such as Cellular response to hypoxia, Cellular responses to stress, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIF3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular response to hypoxiaHIF1AN;EPAS1B;EGLN1B;EGLN3;HIF3A;EGLN2;HIF1AL
Cellular responses to stressDPF1;EP400;RBBP7;BAG5;GABARAP;UVRAG;RBBP4;PRDX2;MAPKAPK2B
Developmental BiologyEFNA5;EZRA;COL9A1B;POU5F3;CDK19;BNIP2;EBF1;LGI1;CSNK2B
Hypoxic and oxygen homeostasis regulation of HIF-1-alphaHIF3A;NAA10;COPS5;GNB2L1;HIF1AN
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaEPAS1B;EGLN3;HIF3A;EGLN1B;HIF1AL;EGLN2
Regulation of Hypoxia-inducible Factor (HIF) by oxygenHIF1AL;EPAS1B;HIF1AN;EGLN1B;EGLN2;HIF3A;EGLN3
Regulation of gene expression by Hypoxia-inducible FactorHIF1AL;HIF3A;EPAS1B
Transcriptional regulation of pluripotent stem cellsNR6A1;SALL4;PRDM14;POU5F3;TDGF1;HIF3A;NR5A1;FOXD3;LIN28A

HIF3A has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HIF3A itself. We selected most functions HIF3A had, and list some proteins which have the same functions with HIF3A. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZZZ3;HBP1;FOXO4;DNTT;TRIM30A;CASZ1;IRF3;ZIM2;HIST1H47
RNA polymerase II transcription factor activity, sequence-specific DNA bindingETV5B;PEG3;FOXH1;NPAS4;MED1;SOX15;SIM2;ZNF18;SOX9A
protein dimerization activityTFEC;ATM;SRFA;ANO7;HER5;ZBED4;SIM1;MXD3;SCXB
transcription coactivator activityTFDP1B;RNF14;TUBB3;PIAS2;TAF5L;TADA2B;RARA;GTF2F1;CEBPA
transcription corepressor activityZHX2;NR2F2;E2F8;SUFU;TLE2;HEYL;SAP18;LMCD1;PBXIP1

HIF3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIF3A here. Most of them are supplied by our site. Hope this information will be useful for your research of HIF3A.

Shida, T; Nozawa, T; et al. Fluvastatin-induced reduction of oxidative stress ameliorates diabetic cardiomyopathy in association with improving coronary microvasculature. HEART AND VESSELS 29:532-541(2014).
Li, JP; Li, FYL; et al. Lipopolysaccharide and Hypoxia-Induced HIF-1 Activation in Human Gingival Fibroblasts. JOURNAL OF PERIODONTOLOGY 83:816-824(2012).
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