hif3a
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  • Official Full Name
  • hypoxia inducible factor 3, alpha subunit
  • Background
  • The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
  • Synonyms
  • HIF3A; hypoxia inducible factor 3, alpha subunit; IPAS; MOP7; PASD7; HIF-3A; bHLHe17; hypoxia-inducible factor 3-alpha; HIF3-alpha-1; member of PAS protein 7; inhibitory PAS domain protein; PAS domain-containing protein 7; basic-helix-loop-helix-PAS protein MOP7; class E basic helix-loop-helix protein 17;
Cat.#:HIF3A-4749HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HIF3A Protein, GST-tagged
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Cat.#:HIF3A-2842RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HIF3A Protein
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Cat.#:HIF3A-5563HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HIF3A 293 Cell Lysate
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Involved Pathway

HIF3A involved in several pathways and played different roles in them. We selected most pathways HIF3A participated on our site, such as Cellular response to hypoxia, Cellular responses to stress, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIF3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cellular response to hypoxia
HIF3A; HIF1AN; HIF1AL; EPAS1B; EGLN1B; EGLN3; EGLN2
Cellular responses to stress
NUPL2; HIST1H1A; CBX8A; NUP50; DPF1; PRDX2; Txn1; ACD; HIST1H1B; CHMP4B
Developmental Biology
KALRNB; MED18; DPYSL5B; MED29; PSPN; ACVR1C; HFE2; ARPC3; CEBPB; NKX2.2A
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
GNB2L1; HIF3A; COPS5; HIF1AN; NAA10
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
EPAS1B; EGLN3; HIF1AL; EGLN2; HIF3A; EGLN1B
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
EGLN2; EPAS1B; HIF1AL; HIF1AN; EGLN1B; EGLN3; HIF3A
Regulation of gene expression by Hypoxia-inducible Factor
HIF1AL; EPAS1B; HIF3A
Transcriptional regulation of pluripotent stem cells
NR6A1; HIF3A; SALL4; LIN28A; NR5A1; PRDM14; POU5F3; FOXD3; TDGF1

Protein Function

HIF3A has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HIF3A itself. We selected most functions HIF3A had, and list some proteins which have the same functions with HIF3A. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein PCBP3; DBX1B; UNCX4.1; GTF2E2; ZFP14; TDEANC2; ZNF789; ZNF483; AHR; HOXD13
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein XBP1; FOXJ1A; PAX6B; ELF3; SIM2; JUND; FOXC1A; CC2D1B; FOXQ1; ZNF434
Function protein dimerization activity
Related Protein DBI; PDCD6; TCF3A; FBXW11B; ERBB2; HES7; HER13; ASCL5; TAL2; HER3
Function transcription coactivator activity
Related Protein MED17; MED16; NCOA4; KAT2B; RARA; PRPF6; PARK7; TAF11; ABRA; FUS
Function transcription corepressor activity
Related Protein AJUBA; TLE4; HEYL; NCOR1; WWTR1; ZFPM2; YAF2; NPAT; SRSF2; FOXP3

HIF3A Related Articles

Shida, T; Nozawa, T; et al. Fluvastatin-induced reduction of oxidative stress ameliorates diabetic cardiomyopathy in association with improving coronary microvasculature. HEART AND VESSELS 29:532-541(2014).
Li, JP; Li, FYL; et al. Lipopolysaccharide and Hypoxia-Induced HIF-1 Activation in Human Gingival Fibroblasts. JOURNAL OF PERIODONTOLOGY 83:816-824(2012).