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HIPK1

  • Official Full Name

    homeodomain interacting protein kinase 1

  • Overview

    The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
  • Synonyms

    HIPK1; homeodomain interacting protein kinase 1; homeodomain-interacting protein kinase 1; KIAA0630; MGC26642; MGC33446; MGC33548; Myak; Nbak2; nuclear body-associated kinase 2; nuclear body associated kinase 2b; homeodomain interacting protein kinase 1-l;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HIPK1-1413H Active Recombinant Human HIPK1, GST-tagged Sf9 Insect Cell GST 156-555 aa
Human HIPK1-7858H Recombinant Human HIPK1 protein, His & T7-tagged E.coli His/T7 Met1~Lys290 (Accession # Q86Z02)
Human HIPK1-516H Recombinant Human HIPK1, GST-tagged Sf9 Insect Cell GST
Human HIPK1-524H Recombinant Human HIPK1, GST-tagged Sf21 Insect Cell GST
Human HIPK1-4759H Recombinant Human HIPK1 Protein, GST-tagged Wheat Germ GST
Human HIPK1-1127H Recombinant Human HIPK1 Protein (T158-I555), GST tagged Insect Cell GST T158-I555
Human HIPK1-1126H Recombinant Human HIPK1 Protein (T158-I555), Tag Free Insect Cell No tag T158-I555
Human HIPK1-3533HF Recombinant Full Length Human HIPK1 Protein, GST-tagged In Vitro Cell Free System GST 1075 amino acids
Mouse HIPK1-7636M Recombinant Mouse HIPK1 Protein Mammalian Cell His
Mouse HIPK1-4169M-B Recombinant Mouse HIPK1 Protein Pre-coupled Magnetic Beads HEK293
Mouse HIPK1-4169M Recombinant Mouse HIPK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HIPK1 Related Articles

HIPK1 involved in several pathways and played different roles in them. We selected most pathways HIPK1 participated on our site, such as Gene Expression, Generic Transcription Pathway, YAP1- and WWTR1 (TAZ)-stimulated gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionHNRNPA0L;KRBA1;SMG8;EXOSC8;JARID2B;TDRD1;DDX4;SF3B2;ANP32A
Generic Transcription PathwayNR4A2B;ZNF184;ZNF221;ZNF777;ZNF573;RARAB;LRPPRC;CCNT2B;ZNF493
YAP1- and WWTR1 (TAZ)-stimulated gene expressionTEAD3B;TBX5A;NKX2;HIPK1;TEAD1A;TBX5

HIPK1 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HIPK1 itself. We selected most functions HIPK1 had, and list some proteins which have the same functions with HIPK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSPHK2;UCK2B;NADK;ATP1A3A;RUVBL2;EGFR;MYO6A;ERCC6L;PASK
protein bindingCSF2RA;IQCE;GIP;MBNL3;ATP6V0A4;RPS25;TGIF1;RNF185;RABIF
protein serine/threonine kinase activityTESK2;ROCK2;KALRN;GRK7B;PRKACAB;MASTL;TRPM6;Aatk;PRKAA2

HIPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIPK1.

FHL3; TP53; Rassf5; saicar; PKM; Daxx; RASSF5; DAXX; PRPF40A; SKIL; GLUL; UBE2I; SNIP1; ATP13A2; bosutinib; dasatinib

Polonio-Vallon, T; Kirkpatrick, J; et al. Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization. CELL CYCLE 13:115-125(2014).
Zhou, G; Wang, H; et al. p38 MAP Kinase Interacts with and Stabilizes Pancreatic and Duodenal Homeobox-1. CURRENT MOLECULAR MEDICINE 13:377-386(2013).
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