hipk1
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  • Official Full Name
  • homeodomain interacting protein kinase 1
  • Background
  • The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
  • Synonyms
  • HIPK1; homeodomain interacting protein kinase 1; homeodomain-interacting protein kinase 1; KIAA0630; MGC26642; MGC33446; MGC33548; Myak; Nbak2; nuclear body-associated kinase 2; nuclear body associated kinase 2b; homeodomain interacting protein kinase 1-l
Cat.#:HIPK1-4759HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HIPK1 Protein, GST-tagged
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Cat.#:HIPK1-516HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HIPK1, GST-tagged
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Cat.#:HIPK1-524HTag:GST
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human HIPK1, GST-tagged
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Cat.#:HIPK1-7858HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HIPK1 protein, His & T7-tagged
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Cat.#:HIPK1-7636MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HIPK1 Protein
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Cat.#:HIPK1-1413HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HIPK1 (Active), GST-tagged
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Involved Pathway

HIPK1 involved in several pathways and played different roles in them. We selected most pathways HIPK1 participated on our site, such as Gene Expression, Generic Transcription Pathway, YAP1- and WWTR1 (TAZ)-stimulated gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
SNAPC1B; CSTF3; ESR2B; MTA1; DDX6; COX6A1; NR4A2A; ZNF473; ZNF706; CTGF
Generic Transcription Pathway
ZNF559; ZNF566; ZNF729; ZNF212; ZNF317; TRIM33; C7orf59; ZNF230; ZNF394; ZNF167
YAP1- and WWTR1 (TAZ)-stimulated gene expression
HIPK1; TBX5A; NKX2; TEAD1A; TEAD3B; TBX5

Protein Function

HIPK1 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HIPK1 itself. We selected most functions HIPK1 had, and list some proteins which have the same functions with HIPK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MOV10B.2; DQX1; PI4K2B; NIM1; STK39; IDH3G; ENTPD2; GLUL; PHKG1; MYO3B
Function protein binding
Related Protein PSRC1; COLQ; APBA2; KPNA5; DUSP5; TDRD9; SPG7; PMP2; CYTH1; STIM2
Function protein serine/threonine kinase activity
Related Protein SGK1; TRIOA; LRRK1; TGFBR1A; CDC42BPG; LIMK2; MYO3B; ROCK2; STK33; HIPK2

Interacting Protein

HIPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIPK1.
FHL3; TP53; Rassf5; saicar; PKM; Daxx; RASSF5; DAXX; PRPF40A; SKIL; GLUL; UBE2I; SNIP1; ATP13A2; bosutinib; dasatinib

HIPK1 Related Articles

Polonio-Vallon, T; Kirkpatrick, J; et al. Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization. CELL CYCLE 13:115-125(2014).
Zhou, G; Wang, H; et al. p38 MAP Kinase Interacts with and Stabilizes Pancreatic and Duodenal Homeobox-1. CURRENT MOLECULAR MEDICINE 13:377-386(2013).