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HLA-DOB

Official Full Name

major histocompatibility complex, class II, DO beta
Overview

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Synonyms

HLA-DOB; major histocompatibility complex, class II, DO beta; HLA class II histocompatibility antigen, DO beta chain; DO beta chain; DOB; DOB_HUMAN; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen DO beta chain; Major histocompatibility complex class II DO beta; Major histocompatibility complex class II DO beta chain; MHC class II antigen DOB;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-DOB-190H	Recombinant Human HLA-DOB, His-tagged	E.coli	His	27-224aa	Inquiry
Human	HLA-DOB-13815H	Recombinant Human HLA-DOB, GST-tagged	E.coli	GST	1-99a.a.	$319 / 25ug
Human	HLA-DOB-4839H	Recombinant Human HLA-DOB Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HLA-DOB-5504HCL	Recombinant Human HLA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	HLA-DOB-6413H	Recombinant Human HLA-DOB Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
HLA-DOB Related Articles

HLA-DOB involved in several pathways and played different roles in them. We selected most pathways HLA-DOB participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phagosome	HLA-DRB4;FCGR3;COLEC12;HLA-DRB5;TUBA8L3;ABCB3L1;DYNC1LI1;ITGB2L;Ctsl
Cell adhesion molecules (CAMs)	NEO1;SDC1;BLB2;NRXN1;BLA;OCLNA;HLA-DRB3;Icosl;CLDN15LA
Antigen processing and presentation	KIR3DL2;RFXANK;TAP1;HLA-DRA;KIR2DL4;CTSB;HSPA6;HSP90AB1;KLRD1
Intestinal i	IL15;CCR9A;HLA-DOB;MHC2DEB;CCR10;BMA2;HLA-DMB;HLA-DRB5;TGFB1
ne network for IgA production	HLA-DPA1;BLB1;Il2;ITGB7;HLA-DRB4;HLA-DPB1;MHC2DCB;CD28;CXCL12B
Type I diabetes mellitus	CD80;HLA-DPB1;HLA-DRB3;H2-AA;HLA-G;HLA-DRB4;CD28;GAD1;Fasl
Leishmaniasis	NCF1;HLA-DOB;FCGR1;CYBA;ITGAM;TNF;FCGR3B;TGFB3;ELK1
Toxoplasmosis	Toxoplasma Gondii Profilin Family Protein;GNAI3;RELA;IRGM;LAMA2;MYD88;LAMA5;HLA-DRB1;PIK3R3
Staphylococcus aureus infection	HLA-DRB4;FCGR3A;MBL1;H2-AA;HLA-DOB;HLA-DMB;DSG1C;C1QC;HLA-DMA
Tuberculosis	IFNA7;MAPK9;SPHK2;RAB5B;CD209;PIK3C3;NFKB1;CARD9;IFNA10
Influenza A	OAS3;RAF1;HLA-DQA2;IFNA6;PIK3R5;IFNAR2;IFNA5;VDAC1;TNFRSF10C
HTLV-I infection	CDC23;SMAD3;TBP;Fzd4;BUB3;ETS2;HLA-DPA1;H2-AA;HLA-B
Herpes simplex infection	PPP1CA;BLB2;IFNA8;MYD88;MHC2DCB;SRPK1;SRSF1A;MED8;PER1B
Asthma	H2-AA;HLA-DMB;IL13;PRG2;EPX;IL5;MS4A2;HLA-DOA;HLA-DQB1
Autoi	TSHR;CD86;HLA-F;HLA-DOA;IFNA14;TG;IFNA2;IFNA5;FAS
ne thyroid disease	HLA-DQA1;IFNA2;IL4;HLA-DRB3;IFNA13;IFNA21;HLA-DQA2;IFNA6;IFNA4
Inflammatory bowel disease (IBD)	Il2;IL17A;TLR5;HLA-DPB1;IFNGR1;RELA;TGFB3;Il23a;IL21R
Systemic lupus erythematosus	HIST1H4F;H2AFZ;HIST1H2BD;HIST1H4L;HLA-DPB1;HLA-DOA;FCGR1A;ACTN3;H3F3B
Rheumatoid arthritis	TNFSF13;IL18;ATP6AP1;TLR4;TNF;H2-AA;Il23a; Il12b;HLA-DQB1;VEGFA
Allograft rejection	FASLG;CD40;IL12A;H2-AA;CD28;IL4;HLA-DRB4;HLA-A;H2-AB1
Graft-versus-host disease	KIR2DL1;KIR3DL2;HLA-F;FASLG;HLA-B;H2-AB1;HLA-G;HLA-DQA2;IL1B
Viral myocarditis	MYH7;EIF4G3;HLA-C;CASP9;HLA-DOB;ITGAL;RAC2;CASP8;ACTB

HLA-DOB has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DOB itself. We selected most functions HLA-DOB had, and list some proteins which have the same functions with HLA-DOB. You can find most of the proteins on our site.

Function	Related Protein
MHC class II protein complex binding	HLA-DOB;HSP90AB1;PKM2;ATP1B1;HLA-DMA;HLA-DOA;YWHAE;ANXA11;PKM
MHC class II receptor activity	HLA-DRB3;HLA-DQA1;HLA-DQB1;HLA-DRA;HLA-DRB1;HLA-DRB4;HLA-DPA1;HLA-DOA;HLA-DQA2

HLA-DOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DOB here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DOB.

Yucesoy, B; Talzhanov, Y; et al. Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations. VACCINE 31:5381-5391(2013).

van Lith, M; van Ham, M; et al. Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies. IMMUNOGENETICS 54:591-595(2002).