Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

HLA-DOB

  • Official Full Name

    major histocompatibility complex, class II, DO beta

  • Overview

    HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
  • Synonyms

    HLA-DOB; major histocompatibility complex, class II, DO beta; HLA class II histocompatibility antigen, DO beta chain; DO beta chain; DOB; DOB_HUMAN; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen DO beta chain; Major histocompatibility complex class II DO beta; Major histocompatibility complex class II DO beta chain; MHC class II antigen DOB;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-DOB-190H Recombinant Human HLA-DOB, His-tagged E.coli His 27-224aa
Human HLA-DOB-13815H Recombinant Human HLA-DOB, GST-tagged E.coli GST 1-99a.a.
Human HLA-DOB-4839H Recombinant Human HLA-DOB Protein, GST-tagged Wheat Germ GST
Human HLA-DOB-5504HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
Human HLA-DOB-6413H Recombinant Human HLA-DOB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-DOB Related Articles

HLA-DOB involved in several pathways and played different roles in them. We selected most pathways HLA-DOB participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeTUBA2;ITGB1A;H2-Q10;Ctsl;THBS3A;MBL2;ITGB1B.2;MHC2DCB;ATP6V0B
Cell adhesion molecules (CAMs)F11R;GLG1;HLA-F;CD276;CTLA4;CD34;MPZL1;BLA;CLDN1
Antigen processing and presentationCD8A;KIR3DL1;KIR2DL4;KIR2DS3;HSP90AA1;LGMN;HLA-C;TAP2;HLA-DRA
Intestinal iCD80;PIGR;CXCR4A;HLA-DMB;HLA-DPB1;IL-15RA;CD28;CXCR4B;BLB2
ne network for IgA productionHLA-DMB;CCR10;CXCL12;CXCL12A;MHC2DEB;PIGR;HLA-DRB4;IL4;CD80
Type I diabetes mellitusGZMB;Il2;IFNG;HLA-DRA;CD28;INS;HLA-DRB1;HLA-B;H2-Q10
LeishmaniasisMAPK3;FCGR3A;HLA-DPA1;ITGB2L;CR1;HLA-DOA;IL12B;MAPK11;FCGR3B
ToxoplasmosisHLA-DRA;MAPK13;HLA-DOB;IFNGR1;TRAF6;HSPA1B;H2-AB1;LAMB4;HLA-DMB
Staphylococcus aureus infectionHLA-DOA;MASP1;DSG1A;HLA-DPB1;FCGR2B;FCAR;FPR2;HLA-DRB4;MBL2
TuberculosisCD14;BCL2;IL12B;MAPK11;MAPK3;RIPK2;TLR2;IL12A;HLA-DQA2
Influenza AOAS1B;LOC100686744;SOCS3;DNAJB1;HLA-DRB5;BLB1;HLA-DQB1;TNFRSF10A;H2-AA
HTLV-I infectionSMAD4;CCND3;XBP1;SMAD3;NFATC1;NFKB2;H2-Q10;HLA-DRB4;BUB3
Herpes simplex infectionSFRS3B;HNRNPK;CUL1;SRPK1A;MHC1UXA2;CDC34A;PER1A;BF2;PPP1CBL
AsthmaIL9;HLA-DQA2;H2-AA;HLA-DQA1;IL3;HLA-DQB1;CD40LG;HLA-DRA;EPX
AutoiFASLG;IFNA12;IFNA16;HLA-DRB1;Il2;HLA-E;H2-AB1;IFNA7;HLA-B
ne thyroid diseaseHLA-DPA1;CD40;TSHB;IFNA13;HLA-DOA;IFNA10;IFNA6;TG;HLA-DRB4
Inflammatory bowel disease (IBD)TGFB2;NFKB1;RORC;Il23a;IL12RB1;IL4;IL12B;IL17A;HLA-DRB5
Systemic lupus erythematosusACTN3;HIST1H2AH;HIST1H3G;H2AFB1;C1RA;HIST1H2AL;TROVE2;HIST1H3D;HIST1H2BE
Rheumatoid arthritisTGFB3;ATP6V0E1;ATP6V1E1;Ccl12;MMP1A;HLA-DPB1;IL18;Ctsl;MMP3
Allograft rejectionHLA-DMB;IL10;IL5;TNF;PRF1;CD80;IL12A;Fasl;HLA-DPA1
Graft-versus-host diseaseHLA-DRB3;KLRD1;PRF1;HLA-DQB1;KIR2DL3;HLA-E;FASLG;H2-Q10;KIR3DL2
Viral myocarditisHLA-DOB;RAC3;CD40;ABL2;HLA-DOA;RAC1;CASP9;HLA-B;HLA-DRB5

HLA-DOB has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DOB itself. We selected most functions HLA-DOB had, and list some proteins which have the same functions with HLA-DOB. You can find most of the proteins on our site.

Function Related Protein
MHC class II protein complex bindingYWHAE;HLA-DRB1;ANXA11;HSP90AA1;HLA-DOB;HSP90AB1;HLA-DMB;CD81;PKM
MHC class II receptor activityHLA-DRB4;HLA-DOB;HLA-DRA;HLA-DRB3;HLA-DQA1;HLA-DOA;HLA-DQB1;HLA-DRB1;HLA-DQA2

HLA-DOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DOB here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DOB.

Yucesoy, B; Talzhanov, Y; et al. Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations. VACCINE 31:5381-5391(2013).
van Lith, M; van Ham, M; et al. Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies. IMMUNOGENETICS 54:591-595(2002).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All HLA-DOB Products

Required fields are marked with *

My Review for All HLA-DOB Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends