idh3b
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  • Official Full Name
  • isocitrate dehydrogenase 3 (NAD+) beta
  • Background
  • Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. NADP-specific isocitrate dehydrogenase (ICDH).
  • Synonyms
  • IDH3B; isocitrate dehydrogenase 3 (NAD+) beta; isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; mitochondrial; FLJ11043; H-IDHB; IDH3B_HUMAN; Isocitrate dehydrogenase [NAD] subunit beta; isocitrate dehydrogenase 3, beta subunit; Isocitric dehydrogenase; Isocitric dehydrogenase subunit beta; MGC903; NAD(+)-specific ICDH; NAD(+)-specific ICDH subunit beta; NAD+-specific isocitrate dehydrogenase b subunit; NAD+-specific isocitrate dehydrogenase beta; OTTHUMP00000030023; OTTHUMP00000030024; RP46; NAD+-specific ICDH; isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, beta subunit; Isocitrate Dehydrogenase (NADP +); Isocitrate Dehydrogenase; IDP; PICD; IDH; IDCD; IDPC; EC 1.1.1.42; Isocitrate dehydrogenase [NADP] cytoplasmic; Cytosolic NADP-isocitrate dehydrogenase; Oxalosuccinate decarboxylase; NADP(+)-specific ICDH; NADP+-specific ICDH; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrog enase, peroxisomal; isocitrate dehydrogenase 1 (NADP+), soluble; isocitrate dehydrogenase (NADP+); isocitrate dehydrogenase (NADP); oxalsuccinic decarboxylase; isocitrate (NADP) dehydrogenase; isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; NADP-specific isocitrate dehydrogenase; NADP-linked isocitrate dehydrogenase; NADP-dependent isocitrate dehydrogenase; NADP isocitric dehydrogenase; isocitrate dehydrogenase (NADP-dependent); NADP-dependent isocitric dehydrogenase; triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase; NADP+-linked isocitrate dehydrogenase; IDH (ambiguous); dual-cofactor-specific isocitrate dehydrogenase; IDP1; IDP2; IDP3; isocitrate: NADP+ oxidoreductase (decarboxylating)
Cat.#:IDH3B-566HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDH3B Protein (35-385 aa), GST-tagged
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Cat.#:IDH3B-2988RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IDH3B Protein
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Cat.#:IDH3B-610CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IDH3B Protein, His-tagged
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Cat.#:IDH3B-2194RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IDH3B Protein, His-tagged
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Cat.#:IDH3B-3038CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IDH3B
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Cat.#:IDH3B-381ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IDH3B
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Cat.#:ICDH-209STag:
Source (Host):Porcine HeartSpecies:Pig
Product nameNative Swine Isocitrate Dehydrogenase
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Cat.#:IDH3B-5304HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IDH3B 293 Cell Lysate
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Involved Pathway

IDH3B involved in several pathways and played different roles in them. We selected most pathways IDH3B participated on our site, such as Citrate cycle (TCA cycle), Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Citrate cycle (TCA cycle)
MDH1AA; ACO2; IDH3A; IDH2; DLAT; OGDHL; SDHA; PC; ACLYA; PCXB
Metabolic pathways
IL4I1; PYGB; PRPS1; CHKB; ADH7; GCDHB; UGDH; ALPI.2; PPT1; REV3L
Carbon metabolism
ESD; GOT2B; ENO3; PGD; GOT1; DLAT; ANI_1_2390104; TKTB; HKDC1; GPT2L
-Oxocarboxylic acid metabolism
GOT2A; GPT2L; GPT2; IDH3G; IDH3A; GOT1; IDH2; BCAT2; IDH1; GOT2
Biosynthesis of amino acids
ALDOCB; RPIA; TKT; PGK1; ALDOCA; ENO1A; MAT2AB; IDH3G; PGAM1B; TPI1

Protein Function

IDH3B has several biochemical functions, for example, NAD binding, electron carrier activity, isocitrate dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH3B itself. We selected most functions IDH3B had, and list some proteins which have the same functions with IDH3B. You can find most of the proteins on our site.
Function
Related Protein
Function NAD binding
Related Protein AOX3L1; GPD1B; AOX3; CTBP2L; IDH3A; GRHPR; DLD; LDHA; NNT; NDUFS2
Function electron carrier activity
Related Protein CYCSB; AKR7A2; GLRX3; P4HA2; IVD; NCF2; ETFB; GSR; SRD5A1; ETFDH
Function isocitrate dehydrogenase (NAD+) activity
Related Protein IDH3G; IDH3B; IDH3A
Function magnesium ion binding
Related Protein MARK1; NT5C1BA; NCS1; FARSB; NEK6; RPS6KA5; EYA2; TSSK3; IMPA2; RPS6KAL

Interacting Protein

IDH3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH3B here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH3B.
PHLDA3; RAB35; MAPK6; ATXN2; PRMT1; MYC; CLPP

IDH3B Related Articles

Guay, C; Joly, E; et al. A Role for Cytosolic Isocitrate Dehydrogenase as a Negative Regulator of Glucose Signaling for Insulin Secretion in Pancreatic beta-Cells. PLOS ONE 8:-(2013).
Li, HH; Su, JH; et al. Proteomic Investigation of the Sinulariolide-Treated Melanoma Cells A375: Effects on the Cell Apoptosis through Mitochondrial-Related Pathway and Activation of Caspase Cascade. MARINE DRUGS 11:2625-2642(2013).