inpp1
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  • Official Full Name
  • inositol polyphosphate-1-phosphatase
  • Background
  • This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.
  • Synonyms
  • INPP1; inositol polyphosphate-1-phosphatase; inositol polyphosphate 1-phosphatase; EC 3.1.3.57; Inositol polyphosphate 1 phosphatase; IPP; IPPase
Cat.#:INPP1-5112HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human INPP1 Protein, GST-tagged
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Cat.#:INPP1-117HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human INPP1, His-tagged
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Cat.#:INPP1-8223MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INPP1 Protein
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Cat.#:INPP1-5200HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human INPP1 293 Cell Lysate
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Involved Pathway

INPP1 involved in several pathways and played different roles in them. We selected most pathways INPP1 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PLCH1; OCRL; NUDT4; MTMR14; PLCD3; TPI1B; IMPA1; PI4KA; PIK3CG; MTMR1B
Metabolic pathways
PCK2; GPAA1; COQ7; INPP5J; MTHFD2L; MCAT; MPST; AGPAT3; TYMP; HSD3B5
Phosphatidylinositol signaling system
MTMR6; DGKE; INPP1; IP6K1; PIP4K2C; INPP5L; ITPKA; PIK3CA; PPIP5K1; INPP5J

Protein Function

INPP1 has several biochemical functions, for example, inositol-1,3,4-trisphosphate 1-phosphatase activity, inositol-1,4-bisphosphate 1-phosphatase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP1 itself. We selected most functions INPP1 had, and list some proteins which have the same functions with INPP1. You can find most of the proteins on our site.
Function
Related Protein
Function inositol-1,3,4-trisphosphate 1-phosphatase activity
Related Protein SACM1LB; NT5DC3; INPP1; CTDSPL2B; PXYLP1; SGPP2; SACM1LA; SACM1L; PTPRQ; CTDSPL2A
Function inositol-1,4-bisphosphate 1-phosphatase activity
Related Protein INPP1
Function magnesium ion binding
Related Protein NUAK2; ITPK1; ATP8B1; TSSK6; ALPI; IDH2; ENO4; TSSK4; GEM; AASDHPPT

Interacting Protein

INPP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP1.
LIG1; DYNLL1

INPP1 Related Articles

Tarique, KF; Rehman, SAA; et al. Structure-based identification of inositol polyphosphate 1-phosphatase from Entamoeba histolytica. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70:3023-3033(2014).
Tarique, KF; Rehman, SAA; et al. Structural elucidation of a dual-activity PAP phosphatase-1 from Entamoeba histolytica capable of hydrolysing both 3 '-phosphoadenosine 5 '-phosphate and inositol 1,4-bisphosphate. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70:2019-2031(2014).