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INPP1

Official Full Name

inositol polyphosphate-1-phosphatase
Overview

This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.
Synonyms

INPP1; inositol polyphosphate-1-phosphatase; inositol polyphosphate 1-phosphatase; EC 3.1.3.57; Inositol polyphosphate 1 phosphatase; IPP; IPPase;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

C
His
GST
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	INPP1-117H	Recombinant Human INPP1, His-tagged	HEK293	His		Inquiry
Human	INPP1-5200HCL	Recombinant Human INPP1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	INPP1-5112H	Recombinant Human INPP1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	INPP1-5894HF	Recombinant Full Length Human INPP1 Protein, GST-tagged	In Vitro Cell Free System	GST	399 amino acids	Inquiry
Human	INPP1-2728H	Recombinant Human INPP1 Protein (Met1-Thr399), C-His tagged	Mammalian cells	C-His	Met1-Thr399	Inquiry
Mouse	INPP1-8223M	Recombinant Mouse INPP1 Protein	Mammalian Cell	His		Inquiry
Mouse	Inpp1-3543M	Recombinant Mouse Inpp1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	INPP1-4554M	Recombinant Mouse INPP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	INPP1-4554M-B	Recombinant Mouse INPP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
INPP1 Related Articles

INPP1 involved in several pathways and played different roles in them. We selected most pathways INPP1 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Inositol phosphate metabolism	PIP5K1B;PIP5K1A;OCRL;MINPP1B;NUDT4;TPI1;PLCD1B;TPI1A;PIP5K1AB
Metabolic pathways	DDOST;CYP2C38;B3GNT5B;NADKD1;POLR2B;NDUFS8;POLR2E;IMPAD1;RRM1
Phosphatidylinositol signaling system	DGKD;PLCD1A;MTMR14;CALM;PTEN;CALM2B;PPIP5K1;IPMK;INPP5B

INPP1 has several biochemical functions, for example, inositol-1,3,4-trisphosphate 1-phosphatase activity, inositol-1,4-bisphosphate 1-phosphatase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP1 itself. We selected most functions INPP1 had, and list some proteins which have the same functions with INPP1. You can find most of the proteins on our site.

Function	Related Protein
inositol-1,3,4-trisphosphate 1-phosphatase activity	CTDSPL2B;SACM1LA;INPP1;PXYLP1;SACM1L;NT5DC3;SACM1LB;CTDSPL2A;PTPRQ
inositol-1,4-bisphosphate 1-phosphatase activity
magnesium ion binding	NUDT3;CIB4;HPRT1;NT5C1B;ENOPH1;CIB2;PRPS1A;TDP2B;HMGCL

INPP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP1.

LIG1; DYNLL1

Tarique, KF; Rehman, SAA; et al. Structure-based identification of inositol polyphosphate 1-phosphatase from Entamoeba histolytica. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70:3023-3033(2014).

Tarique, KF; Rehman, SAA; et al. Structural elucidation of a dual-activity PAP phosphatase-1 from Entamoeba histolytica capable of hydrolysing both 3 '-phosphoadenosine 5 '-phosphate and inositol 1,4-bisphosphate. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70:2019-2031(2014).