MCCC1
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Official Full Name
methylcrotonoyl-CoA carboxylase 1 (alpha)
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Overview
This gene encodes the large subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. -
Synonyms
MCCC1; methylcrotonoyl-CoA carboxylase 1 (alpha); methylcrotonoyl Coenzyme A carboxylase 1 (alpha); methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; MCCA; 3-methylcrotonyl-CoA carboxylase 1; MCCase subunit alpha; OTTHUMP00000212827; OTTHUMP00000212828; OTTHUMP00000212829; OTTHUMP00000212832; methylcrotonoyl-Coenzyme A carboxylase 1 (alpha); 3-methylcroto; MCC-B;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | MCCC1-401H | Recombinant Human MCCC1 Protein, His-tagged | E.coli | His | ||
Human | MCCC1-4429HCL | Recombinant Human MCCC1 293 Cell Lysate | HEK293 | N/A | ||
Human | MCCC1-2429H | Recombinant Human MCCC1 Protein, His-tagged | E.coli | N-His | Ala512-Glu725 | |
Mouse | MCCC1-9624M | Recombinant Mouse MCCC1 Protein | Mammalian Cell | His | ||
Mouse | Mccc1-8173M | Recombinant Mouse Mccc1 protein, His & T7-tagged | E.coli | His/T7 | Phe484~Lys717 (Accession # Q99MR8) | |
Mouse | MCCC1-5405M | Recombinant Mouse MCCC1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | MCCC1-5405M-B | Recombinant Mouse MCCC1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | MCCC1-3614R | Recombinant Rat MCCC1 Protein | Mammalian Cell | His | ||
Rat | MCCC1-3270R | Recombinant Rat MCCC1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | MCCC1-3270R-B | Recombinant Rat MCCC1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | MCCC1-4019Z | Recombinant Zebrafish MCCC1 | Mammalian Cell | His | ||
Chicken | MCCC1-1689C | Recombinant Chicken MCCC1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
MCCC1 involved in several pathways and played different roles in them. We selected most pathways MCCC1 participated on our site, such as Valine, leucine and isoleucine degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Valine, leucine and isoleucine degradation | ALDH9A1A.1;AOX3;ACAA2;HIBADHB;OXCT2A;OXCT1A;HIBCH;HMGCS1;ALDH3A2 |
Metabolic pathways | ACMSD;TYR;PLA2G2F;PANK1B;KLF15;CYP2P7;SUCLG2;MGAT3A;PFAS |
MCCC1 has several biochemical functions, for example, ATP binding, biotin binding, biotin carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCCC1 itself. We selected most functions MCCC1 had, and list some proteins which have the same functions with MCCC1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | DCLK2;OASL2;PFKFB2;NEK3;NLK2;ERCC6L2;PIK3CA;PIP4K2A;DDX50 |
biotin binding | HLCS;PCXB;PC;PCCA;PCXA;MCCC1;AVR2 |
biotin carboxylase activity | MCCC1;PCXB;ACACA;PC;PCCA;ACACB;PCXA |
metal ion binding | SP8;BMP1B;ADPRM;CYP2AD3;FAM170A;ATP1A1A.2;SALL3;KDM7AB;CHPT1 |
methylcrotonoyl-CoA carboxylase activity | MCCC2;MCCC1 |
protein binding | LILRB4;CDK2;SPATC1;KLK6;ATP6V1E2;LIMS1;ADRB3;RAB1;SH2D3A |
MCCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCCC1.
US11; IFIT1; PPP2R2B; STK4; SIRT4
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