neto2
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  • Official Full Name
  • neuropilin (NRP) and tolloid (TLL)-like 2
  • Background
  • This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms
  • NETO2; neuropilin (NRP) and tolloid (TLL)-like 2; neuropilin and tolloid-like protein 2; FLJ10430; NEOT2; BTCL2; FLJ14724; FLJ90456; Brain specific transmembrane protein; Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 2; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2; NETO 2; NETO2_HUMAN; Neuropilin (NRP) and tolloid (TLL) like 2; Neuropilin and tolloid like protein 2
Cat.#:NETO2-1265HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NETO2, GST-tagged
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Cat.#:NETO2-10589MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NETO2 Protein
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Cat.#:NETO2-3960RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NETO2 Protein
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Cat.#:NETO2-3004RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NETO2 Protein, His-tagged
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Cat.#:NETO2-3872HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NETO2 293 Cell Lysate
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Involved Pathway

NETO2 involved in several pathways and played different roles in them. We selected most pathways NETO2 participated on our site, such as ARMS-mediated activation, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with NETO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
JAK2; RASGEF1A; SPRED2; PSMD9; PHB; SPNA1; FGF8B; FRS2A; SPTA1; JAK3
Activation of NMDA receptor upon glutamate binding and postsynaptic events
CREB1B; AKAP9; NEFLB; ADCY3; PDPK1A; CREB1; NETO2; ADCY1; DLG4; SLC14A2
Adrenergic signaling in cardiomyocytes
ADCY1; TNNC1; PIK3R3B; Adcy4; CACNA1SA; ADRB2; MYH15; CREB1A; AKT3A; PPP2R3A
Aldosterone synthesis and secretion
ADCY8; NETO2; PRKD2; CALML3; HSD3B6; AGTR1; ATF1; HSD3B1; STAR; CYP21A2
Amphetamine addiction
ATF6B; NETO2; CALM3; SLC14A2; HDAC1; CALML5; GRIA4; FOSB; CREB3L4; GRIN1
Axon guidance
ITGB1B.1; KALRNB; FYN; SIAH2; FRS2A; PLXNB2; KIF4A; TRPC3; EPHB4B; COL4A4
BCR signaling pathway
IBTK; CSNK2A1; PAG1; CSK; DOK1; NETO2; MALT1; POU2F2; MAP4K1
CREB phosphorylation through the activation of CaMKII
SLC14A2; NETO2; AKAP9; DLG4; CREB1B; NEFLB

Protein Function

NETO2 has several biochemical functions, for example, ATP binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NETO2 itself. We selected most functions NETO2 had, and list some proteins which have the same functions with NETO2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2NB; VRK1; ATP8B3; PAPD4; CAMK1G; CAMK1GB; NLRP10; HSPH1; CDK14; MYHC4
Function calcium-dependent protein serine/threonine phosphatase activity
Related Protein PPP3R1; NETO2; CAMK2G; PPP3CB
Function calmodulin binding
Related Protein RYR2; CAMK1; CNN3; MYO6; CAMKK1; NRGNA; KCNN3; RASGRF2B; CAMK2D1; MAPKAPK5
Function calmodulin-dependent protein kinase activity
Related Protein CAMK1G; MYLK3; CAMK1GA; CAMK2D2; CAMK1GB; CAMK2D; NETO2; MAPKAPK2A; CAMKK1; PNCK
Function protein binding
Related Protein CDPF1; PPP3CC; SNX2; AKAP9; GTF2IRD2; PIGS; HDAC6; PRDX1; Fzd4; WDR61
Function protein homodimerization activity
Related Protein PSMD7; SNX6; PRPS1L1; BCL2A1A; RQCD1; CPNE1; KCNK9; EVLA; S100A16; ROPN1B

Interacting Protein

NETO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NETO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NETO2.
ytpB; TIA1; WDHD1; KRT17; AIMP2; NELFCD; CCDC82; HS6ST2; TMEM168; TRMT6; IRS2

NETO2 Related Articles

Lindstrom, SH; Ryan, DG; et al. Kainate receptor subunit diversity underlying response diversity in retinal Off bipolar cells. JOURNAL OF PHYSIOLOGY-LONDON 592:1457-1477(2014).
Zhang, W; Devi, SPS; et al. Auxiliary proteins promote modal gating of AMPA- and kainate-type glutamate receptors. EUROPEAN JOURNAL OF NEUROSCIENCE 39:1138-1147(2014).