pag1
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  • Official Full Name
  • phosphoprotein associated with glycosphingolipid microdomains 1
  • Background
  • Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A, bind to this element. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265 kDa nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein. p300 molecules lacking an intact E1A binding site bypass E1A repression even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators.
  • Synonyms
  • PAG1; phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; CBP; Csk binding protein; PAG; transmembrane adaptor protein PAG; Csk-binding protein; transmembrane phosphoprotein Cbp; transmembrane adapter protein PAG; FLJ37858; MGC138364
Cat.#:Pag1-521MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pag1 Protein, His-tagged
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Cat.#:Pag1-522RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pag1 Protein, His-tagged
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Cat.#:PAG1-30060THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAG1, His-tagged
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Cat.#:PAG1-3465HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAG1 293 Cell Lysate
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Involved Pathway

PAG1 involved in several pathways and played different roles in them. We selected most pathways PAG1 participated on our site, such as Adaptive Immune System, BCR signaling pathway, CXCR4-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAG1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
CD300LG; EGFR; CD300LD; RAP1GAP2; CMTM2A; UBE2E3; ITK; CD300E; FBXO3; KIF20A
BCR signaling pathway
PAG1; POU2F2; CSNK2A1; MAP4K1; MALT1; CSK; IBTK; DOK1; NETO2
CXCR4-mediated signaling events
MAPKAP1; GNA13; DNM1; ADRBK1; PAG1; CRK; JAK2; ARR3; BLK; CSK
GAB1 signalosome
PAG1
Immune System
PANX1A; SEC61B; WASF2; CLEC2G; TRIM68; MASP2; PCBP2; SEC23A; TRIM63; TRIM8
Phosphorylation of CD3 and TCR zeta chains
PAG1
Signal Transduction
MDKA; CDC42EP2; GAL; PTHRP2; DACT1; FOXH1; VIP; PMCH; ARHGEF25; EVL
Signaling by EGFR
PTPRK; SPRY1; ADAM12; LRIG1; PAG1

Protein Function

PAG1 has several biochemical functions, for example, SH2 domain binding, SH3/SH2 adaptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAG1 itself. We selected most functions PAG1 had, and list some proteins which have the same functions with PAG1. You can find most of the proteins on our site.
Function
Related Protein
Function SH2 domain binding
Related Protein SHCBP1; CTR9; SRC; SYP; JAK2; KHDRBS2; SIT1; LAT2; LCK; CRK
Function SH3/SH2 adaptor activity
Related Protein SHB; SKAP1; LASP1; SH2B2; GAB1; SH2D1A; SH3BP2; STAP1; GRB2; IRS4
Function protein binding
Related Protein DDX47; RABIF; HOXA1; PRC1; CD72; PPP1CB; EMG1; CASP2; CCDC24; CAMTA2

Interacting Protein

PAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAG1.
FYN; SLC9A3R1; LYN; EGFR; PRKCB; GNB2L1; ppaC; CSK