ppox
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  • Official Full Name
  • protoporphyrinogen oxidase
  • Background
  • This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified.
  • Synonyms
  • PPOX; protoporphyrinogen oxidase; variegate porphyria , VP; PPO; VP; V290M; MGC8485
Cat.#:PPOX-379HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPOX Protein, His/GST-tagged
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Cat.#:Ppox-380RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ppox Protein, His-tagged
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Cat.#:PPOX-1900HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPOX, His-tagged
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Cat.#:PPOX-13208MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPOX Protein
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Cat.#:PPOX-3694ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPOX
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Cat.#:PPOX-2954HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPOX 293 Cell Lysate
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Involved Pathway

PPOX involved in several pathways and played different roles in them. We selected most pathways PPOX participated on our site, such as Porphyrin and chlorophyll metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPOX were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Porphyrin and chlorophyll metabolism
COX15; UGT1A6; FXN; P22; UGT1A9; UROS; UGT2B7; UGT1A6B; UGT1A1; HMBSA
Metabolic pathways
AOC1; GBE1; UGDH; DPYS; DHDPSL; HSD17B7; DPAGT1; CYP2J6; ACMSD; PIGU

Protein Function

PPOX has several biochemical functions, for example, flavin adenine dinucleotide binding, oxygen-dependent protoporphyrinogen oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPOX itself. We selected most functions PPOX had, and list some proteins which have the same functions with PPOX. You can find most of the proteins on our site.
Function
Related Protein
Function flavin adenine dinucleotide binding
Related Protein FMO5; AOX4; ACAD9; ACAD11; ACADS; MTHFR; FMO2; FMO3; ETFA; CYB5R3
Function oxygen-dependent protoporphyrinogen oxidase activity
Related Protein PPOX

Interacting Protein

PPOX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPOX here. Most of them are supplied by our site. Hope this information will be useful for your research of PPOX.
HAP1; IMMT; COPS5; Alas2; Fech; Cpox; Slc25a4; Ppox; Slc25a5; Vdac2; Abcb7; Tfrc; Glrx5; Steap3; Sfxn1; Tmem14c; Slc25a11; Abcb10; Sucla2